Profiling of Serum Metabolites in Canine Lymphoma Using Gas Chromatography Mass Spectrometry
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概要
- 論文の詳細を見る
Canine lymphoma is a common cancer that has high rates of complete remission with combination chemotherapy. However, the duration of remission varies based on multiple factors, and there is a need to develop a method for early detection of recurrence. In this study, we compared the metabolites profiles in serum from 21 dogs with lymphoma and 13 healthy dogs using gas chromatography mass spectrometry (GC-MS). The lymphoma group was separated from the control group in an orthogonal projection to latent structure with discriminant analysis (OPLS-DA) plot using ions of m/z 100–600, indicating that the metabolites profiles in lymphoma cases differed from those in healthy dogs. The lymphoma group was also separated from the control group on OPLS-DA plot using 29 metabolites identified in all serum samples. Significant differences were found for 16 of these metabolites with higher levels in the lymphoma group for 15 of the metabolites and lower levels for inositol. An OPLS-DA plot showed separation of the lymphoma and healthy groups using these 16 metabolites only. These results indicate that metabolites profile with GC-MS may be a useful tool for detection of potential biomarker and diagnosis of canine lymphoma.
- 公益社団法人 日本獣医学会の論文
著者
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Takenaka Shigeo
Laboratory Of Nutrition And Food Science Hagoromo-gakuen College
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Akiyoshi Hideo
Laboratory Of Veterinary Surgery Osaka Prefecture University
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KOMORI Masayuki
Laboratory of Cellular and Molecular Biology, Division of Veterinary Science, Graduate School of Life and Environmental Sciences, Osaka Prefecture University
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KOMORI Yoshiaki
Tsutsujigaoka Veterinary Hospital
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TAMAI Reo
Laboratory of Cellular and Molecular Biology, Division of Veterinary Science, Graduate School of Life and Environmental Sciences, Osaka Prefecture University
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FURUYA Masaru
Laboratory of Veterinary Internal Medicine, Division of Veterinary Science, Graduate School of Life and Environmental Sciences, Osaka Prefecture University
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HATOYA Shingo
Laboratory of Cell Pathobiology, Division of Veterinary Science, Graduate School of Life and Environmental Sciences, Osaka Prefecture University
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YAMAMOTO Ryohei
Laboratory of Veterinary Radiology, Division of Veterinary Science, Graduate School of Life and Environmental Sciences, Osaka Prefecture University
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YOKOI Shin-ichi
Sennan Animal Hospital
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TANI Kenichiro
Tani Animal Hospital
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HIRANO Yuji
Hirano Animal Hospital
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