Spontaneous Extraskeletal Osteosarcoma in a Rabbit (Oryctolagus cuniculus): Histopathological and Immunohistochemical Findings
スポンサーリンク
概要
- 論文の詳細を見る
A spontaneously occurring subcutaneous mass in the left forelimb of a nine-year-old rabbit (Oryctolagus cuniculus) was examined histopathologically and immunohistochemically. Clinically, edema and hemorrhage were seen around the mass. No connection of the tumor mass to the appendicular skeleton was found. The tumor was arranged in a solid growth pattern and irregular bundles, and neoplastic cells were polygonal to spindle-shape. Osteoid (positive for osteocalcin) and multinucleated giant cells were diffusely or focally seen. Neoplastic cells were positive for vimentin, osterix and Ki-67, indicating the nature of osteoblasts with proliferating activity, but negative for α-smooth muscle actin, desmin or CD204. Based on these findings, a diagnosis of extraskeletal osteosarcoma was made, a very rare tumor both in laboratory and pet rabbits.
著者
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Izawa Takeshi
Laboratory Of Plant Molecular Genetics Nara Institute Of Science And Technology
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Kuwamura Mitsuru
Laboratory Of Veterinary Pathology Osaka Prefecture University
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Yamate Jyoji
Laboratory Of Veterinary Pathology Division Of Veterinary Sciences Graduate School Of Life And Environmental Sciences Osaka Prefecture University
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Fujita Daisuke
Kitasuma Animal Hospital Kobe City
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WIJESUNDERA Kavindra
Laboratory of Veterinary Pathology, Division of Veterinary Sciences, Graduate School of Life and Environmental Sciences, Osaka Prefecture University
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IZAWA Takeshi
Laboratory of Veterinary Pathology, Division of Veterinary Sciences, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, 1-58 Rinku-oraikita, Izumisano City, Osaka 598-8532, Japan
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DENDA Yuki
Kitasuma Animal Hospital, 9-5-8 Yokoo, Suma-ku, Kobe City, Hyogo 654-0131, Japan
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SETO Eiko
Kitasuma Animal Hospital, 9-5-8 Yokoo, Suma-ku, Kobe City, Hyogo 654-0131, Japan
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HIROSHI Sasai
Kitasuma Animal Hospital, 9-5-8 Yokoo, Suma-ku, Kobe City, Hyogo 654-0131, Japan
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FUJITA Daisuke
Kitasuma Animal Hospital, 9-5-8 Yokoo, Suma-ku, Kobe City, Hyogo 654-0131, Japan
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