Immunohistochemical Expressions of Main PGE2 Biosynthesis-related Enzymes and PGE2 Receptor in Rat Nephrogenesis
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概要
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Endogenous prostaglandin (PG) E2 plays important roles in renal homeostasis. Immunoexpressions of PGE2 biosynthesis-related enzymes, cyclooxygenase (COX)-2 and microsomal PGE2 synthetase (mPGES)-1 and EP4 (a PGE2 receptor), were investigated in renal development. Kidney tissues were obtained from fetuses on gestation days 18 and 21 and neonates on days 1 to 18. In fetuses and early neonates, the expressions of COX-2, mPGES-1 and EP4 were observed in developing renal tubules, indicating that COX-2 and its product, PGE2, play important roles in blastemal cell-derived renal tubular development via EP4. Cyclin D1 expression was seen in both the nucleus and cytoplasm of the developing tubules. These findings differed from the decreased COX-2 expression and exclusive nuclear expression of cyclin D1 seen in abnormal epithelial regeneration of injured renal tubules in cisplatin-treated rats in our previous articles. Collectively, PGE2, induced by COX-2, regulates renal tubular epithelial formation via EP4.
著者
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Izawa Takeshi
Laboratory Of Plant Molecular Genetics Nara Institute Of Science And Technology
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Kuwamura Mitsuru
Vet. Pathol. Osaka Pref. Uni.
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Kuwamura Mitsuru
Laboratory Of Veterinary Pathology Osaka Prefecture University
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Yamate Jyoji
Laboratory Of Veterinary Pathology Division Of Veterinary Sciences Graduate School Of Life And Environmental Sciences Osaka Prefecture University
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Yamamoto Emi
Laboratory Of Veterinary Pathology Life And Environmental Sciences Osaka Prefecture University
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Yamate Jyoji
Laboratory of Veterinary Pathology, Life and Environmental Sciences, Osaka Prefecture University, Rinkuu Ourai Kita 1-58, Izumisano, Osaka 598-8531, Japan
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Izawa Takeshi
Laboratory of Veterinary Pathology, Life and Environmental Sciences, Osaka Prefecture University, Rinkuu Ourai Kita 1-58, Izumisano, Osaka 598-8531, Japan
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Yamamoto Emi
Laboratory of Veterinary Pathology, Life and Environmental Sciences, Osaka Prefecture University, Rinkuu Ourai Kita 1-58, Izumisano, Osaka 598-8531, Japan
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Kuwamura Mitsuru
Laboratory of Veterinary Pathology, Life and Environmental Sciences, Osaka Prefecture University, Rinkuu Ourai Kita 1-58, Izumisano, Osaka 598-8531, Japan
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