Anti-Inflammatory Potency of Oral Disulfiram Compared with Dexamethasone on Endotoxin-Induced Uveitis in Rats
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概要
- 論文の詳細を見る
To investigate potency of oral disulfiram (DSF) compared with that of dexamethasone (Dexa), on endotoxin-induced uveitis (EIU) in rats. The oral administration with 750 mg/kg DSF suppressed the number of inflammatory cells, protein concentration, and levels of tumor necrosis factor (TNF)-α, Nitric oxide (NO) and prostaglandin (PG) E2 in the aqueous humor and improved the histiologic status of the ocular tissue at 24 hr after lipopolysaccharide (LPS) injection. The anti-inflammatory potency of DSF oral administration was as strong as that observed with 0.5 mg/kg Dexa in the present study. The results suggest that DSF might pave the way for a novel therapeutic agent for the management of uveitis.
- 社団法人 日本獣医学会の論文
著者
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HORI Yasutomo
Department of Small Animal Internal Medicine, School of Veterinary Medicine, Kitasato University
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Nagai Noriaki
Department of Pharmacy, Kinki University
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Kanai Kazutaka
Department of Small Animal Internal Medicine, School of Veterinary Medicine, Kitasato University
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ITOH Naoyuki
Department of Small Animal Internal Medicine, School of Veterinary Medicine, Kitasato University
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Ito Yoshimasa
Department Of Chemistry Faculty Of Integrated Arts And Sciences The University Of Tokushima
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Hoshi Fumio
Department Of Small Animal Internal Medicine School Of Veterinary Medicine Kitasato University
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HIGUCHI Seiichi
Department of Food Science and Technology, Faculty of Agriculture, Kyushu University
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CHIKAZAWA Seishirou
Department of Small Animal Internal Medicine, School of Veterinary Medicine, University of Kitasato
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Hori Yasutomo
Department Of Internal Medicine School Of Veterinary Medicine & Animal Science Kitasato Universi
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KANAI Kazutaka
Department of Small Animal Internal Medicine, School of Veterinary Medicine, University of Kitasato
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HOSHI Fumio
Department of Small Animal Internal Medicine, School of Veterinary Medicine, University of Kitasato
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HORI Yasutomo
Department of Small Animal Internal Medicine, School of Veterinary Medicine, University of Kitasato
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NAGAI Noriaki
Department of Advanced Design for Pharmaceuticals, School of Pharmacy, University of Kinki
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ITO Yoshimasa
Department of Advanced Design for Pharmaceuticals, School of Pharmacy, University of Kinki
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HIGUCHI Seiichi
Department of Small Animal Internal Medicine, School of Veterinary Medicine, University of Kitasato
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ITOH Naoyuki
Department of Small Animal Internal Medicine, School of Veterinary Medicine, University of Kitasato
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KANAI Kazutaka
Department of Small Animal Internal Medicine, School of Veterinary Medicine, Kitasato University, 23–35–1 Higashi, Towada, Aomori 034–8628, Japan
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