Downregulation of Hepatic Cytochrome P450 3A in Mice Infected with Babesia microti
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概要
- 論文の詳細を見る
To investigate effects of Babesia infection on drug metabolism, we intraperitoneally inoculated B. microti into ICR mice and measured the expression and activity of hepatic cytochrome P450 (CYP) 3A, a major drug-metabolizing enzyme. Twelve days after infection, CYP3A11 mRNA, CYP3A protein and activity and mRNAs of nuclear receptors, which participate in CYP3A expression, were significantly reduced. These results suggest that B. microti infection suppresses CYP3A-dependent drug metabolism. Additionally, tumor necrosis factor (TNF)-α and nitric oxide synthase (NOS) 2 mRNAs were induced in the infected mouse liver. Since TNF-α is one of the potent mediators that induce NOS2 and repress CYP3A transcription, the possible involvement of TNF-α in this downregulation of CYP3A was discussed.
著者
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Ishizuka Mayumi
Laboratory Of Toxicology
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Hoshi Fumio
Department Of Small Animal Internal Medicine School Of Veterinary Medicine Kitasato University
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Igarashi Ikuo
National Research Center For Protozoan Diseases Obihiro University Of Agriculture And Veterinary Med
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Kitamura Hiroshi
Department Of Applied Chemistry
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Shimamoto Yoshinori
Department Of Toxicology Faculty Of Veterinary Medicine Hokkaido University
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Yokoyama Naoaki
National Research Center For Protozoan Diseases Obihiro University Of Agriculture And Veterinary Med
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SHIMAMOTO Yoshinori
Department of Veterinary Teaching Hospital, School of Veterinary Medicine, Kitasato University
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SASAKI Mizuki
Department of Veterinary Parasitology, School of Veterinary Medicine, Kitasato University
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IKADAI Hiromi
Department of Veterinary Parasitology, School of Veterinary Medicine, Kitasato University
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