Repeated Treatment with Furazolidone Induces Multiple Cytochrome P450-Related Activities in Chicken Liver, but not in Rat Liver
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概要
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The nitrofuran antimicrobial agent, furazolidone (FZ), is still used in veterinary medicine in some countries in the Middle and Far Eastern countries. The present study aimed to investigate the effects of successive bolus doses of FZ and its metabolite 3-amino-2-oxazolidinone (AOZ) on cytochrome P450 (CYP)-related activities in the livers of rats and chickens. Female Wistar rats and white Leghorn chickens were orally administered FZ once a day for 4 consecutive days. FZ-treated chickens showed an increase in multiple CYP-related activities, however, rats treated with FZ did not show these changes. In chickens, treatment with FZ also induced production of microsomal CYP2C6-like apoprotein. The present study demonstrated that FZ caused a multiple-type induction of CYP-related activities in chickens, but not in rats.
著者
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IKENAKA Yoshinori
Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Graduate School of Veteri
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Ishizuka Mayumi
Laboratory Of Toxicology
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Kazusaka Akio
Laboratory Of Toxicology Department Of Environmental Veterinary Sciences
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Fujita Shoichi
Laboratory Of Toxicology
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NAKAYAMA Shouta
Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Graduate School of Veteri
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SASAKI Nobuo
Laboratory of Surgery, Veterinary Medical Science, The University of Tokyo
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KAZUSAKA Akio
Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Kita 18, Nishi 9, Sapporo 060–0818, Japan
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MATUMOTO Tomoyuki
Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Kita 18, Nishi 9, Sapporo 060–0818, Japan
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FUJITA Shoichi
Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Kita 18, Nishi 9, Sapporo 060–0818, Japan
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IKENAKA Yoshinori
Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Kita 18, Nishi 9, Sapporo 060–0818, Japan
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SASAKI Nobuo
Laboratories of Veterinary Surgery, Division of Veterinary Medical Science, Graduate School of Agricultural and Life Sciences, The University of Tokyo
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NAKAYAMA Shouta
Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Kita 18, Nishi 9, Sapporo 060–0818, Japan
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