Antigenotoxic effect of Pleurotus cornucopiae extracts on the mutagenesis of Salmonella typhimurium TA 98 elicited by benzo［a］pyrene and oxidative DNA lesions in V 79 hamster lung cells
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概要
- 論文の詳細を見る
Pleurotus cornucopiae (PC) mushroom with a brilliant yellow pileus is found in the field and known in Japan as Tamogi dake mushroom. The purpose of this paper is to investigate the mechanism of the antimutagenic effect of PC mushroom using both the Ames test and Comet assay. We have found a strong inhibitory effect of both aqueous and organic PC extracts on the mutagenicity elicited by benzo［a］pyrene (B［a］P), This inhibition was dosedependent in reaction mixtures containing cytosolic and microsomal fractions (S-9) from untreated rat liver as well as in those containing S-9 from aryl hydrocarbon receptor (Ah) ligand of Sudan III-treated rats. Sudan III was a potent inducer of cytochrome P4501A (CYP1A) activity.We treated rats with Sudan III to enhance the metabolic activation of B［a］P by the S-9 fraction. To explain whether this antimutagenicity was due to the inhibition of CYP1A activity that metabolically activates B［a］P, we tested the effects of the extracts on activities of CYP1A1 and CYP1A2, represented by ethoxyresorufin Odeethylase (EROD) and methoxyresorufin O-demethylase (MROD) , respectively. Both aqueous and organic extracts inhibited EROD activity at all dose levels, while the inhibitory effect was only observed at high doses with regard to MROD activity. Furthermore, pre-treatment of Chinese hamster V79 cells with PC extracts significantly reduced H202-induced-DNA damage, indicating that PC extracts provide a protective effect against oxidative DNA damage. These results indicate that whole-mushroom extracts contain compounds that may inhibit the metabolic activation of B［a］P by CYP1A1as well as prevent oxidative DNA damage.
- 北海道大学の論文
- 2005-02-28
著者
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KAZUSAKA Akio
Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Graduate School of Veteri
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FUJITA Shoichi
Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Graduate School of Veteri
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Ishizuka Mayumi
北海道大学 獣医学研究科毒性学
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Ishizuka Mayumi
北海道大学 獣医学研究科環境獣医科学講座毒性学
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Ishizuka Mayumi
北海道大学 獣医学研究科
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Ishizuka Mayumi
Laboratory Of Toxicology Department Of Environmental Veterinary Sciences Graduate School Of Veterina
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Muzandu Kaampwe
北海道大学 獣医学研究科
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Muzandu Kaampwe
北海道大学 獣医学研究科環境獣医科学講座毒性学
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Muzandu Kaampwe
Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Graduate School of Veteri
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Shaban Zein
Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Graduate School of Veteri
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Bohi KhloodM.El.
Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Graduate School of Veteri
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Sabik Laila
Department of Forensic Medicine& Clinical Toxicology, Faculty of Medicine, Zagazig University
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Soliman Mohamed
Laboratory of Biochemistry, Department of Biomedical science, Graduate School of Veterinary Medicine
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Ishizuka Mayumi
Hokkaido Univ. Sapporo Jpn
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Fujita S
Laboratory Of Toxicology Department Of Environmental Veterinary Sciences Graduate School Of Veterina
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Fujita Shoichi
北海道大学 獣医研究 環境獣医
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SHABAN Zein
北海道大学大学院獣医学研究科毒性学教室
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Saito Masayuki
日本獣医生命科学大学 獣医保健看護学科臨床部門
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Muzandu K
Hokkaido Univ. Sapporo Jpn
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Sabik Laila
Department Of Forensic Medicine& Clinical Toxicology Faculty Of Medicine Zagazig University
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Ishizuka Mayumi
Laboratory Of Toxicology
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Kazusaka Akio
Laboratory Of Toxicology Department Of Environmental Veterinary Sciences
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Ishizuka Mayumi
Laboratory Of Toxicology Graduate School Of Veterinary Medicine Hokkaido University
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Fujita Shoichi
Laboratory Of Toxicology
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Bohi Khloodm.el.
Laboratory Of Toxicology Department Of Environmental Veterinary Sciences Graduate School Of Veterina
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Fujita Shoichi
Laboratory Of Toxicology Graduate School Of Veterinary Medicine Hokkaido University
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Ishizuka Mayumi
Laboratory Of Toxicology Department Of Environmental Veterinary Sciences Graduate School Of Veterina
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Kazusaka Akio
Lavoratory Of Toxicology Graduate School Of Veterinary Medicine Hokkaido University
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Kazusaka Akio
Graduate School Of Vet. Med. Hokkaido Univ.
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El. Bohi
Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University
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