Protective effect of Pleurotus cornucopiae mushroom extract on carbon tetrachloride-induced hepatotoxicity
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概要
- 論文の詳細を見る
Pleurotus cornucopiae (PC) mushrooms are found in the field and commonly known in Japan as Tamogidake mushrooms. The present study investigated the protective effects of an aqueous extract of PC on carbon tetrachloride (CCl4)-induced hepatotoxicity and the possible mechanism involved in this protection including cytochrome P450 (CYP) 2E1. Wistar rats were pretreated with aqueous extracts of PC (0, 100, 200, and 400 mg/kg) orally for 8 days prior to the intraperitoneal administration of a single dose of CCl4 (0.5 ml/kg) or corn oil. Pretreatment with PC mushroom extract significantly prevented the increased serum enzyme activities of alanine and aspartate aminotransferases in a dose-dependent manner, and suppressed the expression of CYP2E1. PC mushroom extract also protected hepatocytes from the damage effects of CCl4 as remarked by histological and electromicroscopical findings. It was concluded that repeated daily doses of aqueous extracts of PC mushroom reduced the toxic effects exerted by CCl4 on the liver.
- Graduate School of Veterinary Medicine, Hokkaido Universityの論文
著者
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Ishizuka Mayumi
北海道大学 獣医学研究科毒性学
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Ishizuka Mayumi
北海道大学 獣医学研究科環境獣医科学講座毒性学
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Ishizuka Mayumi
北海道大学 獣医学研究科
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Muzandu Kaampwe
北海道大学 獣医学研究科
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Muzandu Kaampwe
北海道大学 獣医学研究科環境獣医科学講座毒性学
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Ishizuka Mayumi
Hokkaido Univ. Sapporo Jpn
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Fujita S
Laboratory Of Toxicology Department Of Environmental Veterinary Sciences Graduate School Of Veterina
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SHABAN Zein
北海道大学大学院獣医学研究科毒性学教室
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Ishizuka Mayumi
Laboratory Of Toxicology Graduate School Of Veterinary Medicine Hokkaido University
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Fujita Shoichi
Laboratory Of Toxicology Graduate School Of Veterinary Medicine Hokkaido University
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