Downregulation of male-specific cytochrome P450 by profenofos

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概要

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• The health hazards of individual organophosphorus insecticides have been characterized by their acute toxicity, mainly by investigating their cholinesterase inhibition. However, the chronic effects of most of these toxicants on the drug-metabolizing enzymes have not been investigated. Profenofos (O-4-bromo-2-chlorophenyl O-ethyl S-propyl phosphorothioate) is an organophosphorus pesticide widely used in cotton cultivation. In the present study, we investigated the effect of profenofos on male-specific cytochrome P450 (CYP) enzymes in adult Wistar rats. We orally administered 17.8 mg/kg body weight, twice weekly for 65 days. Profenofos downregulated levels of hepatic and testicular CYP2C11 and CYP3A2 mRNA and protein expression. Testicular aromatase (CYP19A) mRNA was decreased in the profenofos-treated rats compared to controls. Overall, the present study suggests that profenofos acts as an endocrine disruptor of male-specific CYP enzymes and affects testosterone concentration, which implicates its deleterious effects on animal or human males chronically exposed to organophosphorus pesticide.

• The Graduate School of Veterinary Medicine, Hokkaido Universityの論文

著者

• Ishizuka Mayumi

  北海道大学 獣医学研究科毒性学

• Ishizuka Mayumi

  北海道大学 獣医学研究科環境獣医科学講座毒性学

• Ishizuka Mayumi

  北海道大学 獣医学研究科毒性学教室

• Ishizuka Mayumi

  北海道大学 獣医学研究科

• 坂本 健太郎

  北海道大学大学院獣医学研究科毒性学教室

• Ishizuka Mayumi

  Hokkaido Univ. Sapporo Jpn

• Fujita S

  Laboratory Of Toxicology Department Of Environmental Veterinary Sciences Graduate School Of Veterina

• Fujita Shoichi

  北海道大学 獣医研究 環境獣医

• Fujita Shoichi

  Laboratory Of Toxicology Department Of Environmental Veterinary Sciences Graduate School Of Veterina

• Sakamoto Kentaro

  Laboratory Of Toxicology Department Of Environmental Veterinary Sciences Graduate School Of Veterina

• Sakamoto Kentaro

  Laboratory Of Toxicology Department Of Environmental Veterinary Science School Of Veterinary Medicin

• Sakamoto Kentaro

  Department Of Environmental Veterinary Sciences Graduate School Of Veterinary Medicine Hokkaido Univ

• Ishizuka Mayumi

  Laboratory Of Toxicology Graduate School Of Veterinary Medicine Hokkaido University

• Fujita Shoichi

  Laboratory Of Toxicology Graduate School Of Veterinary Medicine Hokkaido University

• Ishizuka Mayumi

  Laboratory Of Toxicology Department Of Environmental Veterinary Sciences Graduate School Of Veterina

• Sakamoto Kentaro

  Hokkaido Univ. Sapporo

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