EVIDENCE OF PARTIAL INVOLVEMENT OF P-450 2D IN MUTAGENIC ACTIVATION OF BENZO(a)PYRENE IN LIVER S-9 FRACTION FROM UNTREATED RATS
スポンサーリンク
概要
- 論文の詳細を見る
In order to clarify which species of cytochrome P-450 is involved in activation of benzo(a)pyrene (BP) in untreated rat liver, strain and sex differences in the ability of rat liver 9000 g supernatant (S-9) to mutagenically activate BP was investigated using Ames test. The numbers of histidine revertants in Ames test after pre-incubation of TA 98 strain of Salmonella typhimurium and BP with liver S-9 from male rats were markedly higher than those obtained using female rats. In addition, a marked strain difference (Wistar>DA) in the ability of liver S-9 from Wistar and DA rats to activate BP was observed. Antibody against cytochrome P-450 2D inhibited up to 50% of the revertant formation by the activation of BP with liver S-9 from male Wistar rats. These results indicate the partial involvement of cytochrome P-450 2D subfamily as well as cytochrome P-450 species specific to male rats in activation of BP to ultimate mutagen in untreated rat liver.
- 日本トキシコロジー学会の論文
- 1994-11-30
著者
-
Fujita Shoichi
Department Of Biopharmaceutics Faculty Of Pharmaceutical Sciences Chiba University
-
Masuda M
Laboratory Of Toxicology Graduate School Of Veterinary Medicine Hokkaido University
-
MASUDA Makihiko
Department of Toxicology, Faculty of Veterinary Medicine, Hokkaido University
-
KAZUSAKA Akio
Department of Toxicology, Faculty of Veterinary Medicine, Hokkaido University
-
NUKUZUMA Chiyoko
Department of Toxicology, Faculty of Veterinary Medicine, Hokkaido University
-
Fujita Shoichi
Department Of Biopharmaceutics Faculty Of Phamaceutical Sciences Chiba University
-
Fujita Shoichi
Laboratory Of Toxicology Graduate School Of Veterinary Medicine Hokkaido University
-
Nukuzuma Chiyoko
Department Of Toxicology Faculty Of Veterinary Medicine Hokkaido University
-
Nukuzuma Chiyoko
Department Of Pathology Hokkaido University School Of Medicine
-
Nukuzuma Chiyoko
Department Of Microbiology Kobe Institute Of Health
関連論文
- 22B-10-5 Norsalsolinol, an endogeneous dopaminergic neurotoxin, inhibits dopamine secretion in PC12 cells.
- 21WA-04-3 Seal Liver P450, as a Marker Enzyme for Marine Pollution.
- Effects of concurrent exposure to 3-methylcholanthrene and vitamin A on fetal development in rats
- Laboratory of Toxicology
- Regio- and Stereoselectivity in Propranolol Metabolism by Dog Liver Microsomes and the Expressed Dog CYP2D15^1
- Protective effect of Pleurotus cornucopiae mushroom extract on carbon tetrachloride-induced hepatotoxicity
- Protection by Nigella sativa against carbon tetrachloride-induced downregulation of hepatic cytochrome P450 isozymes in rats
- Pesticide resistance in wild mammals : Mechanisms of anticoagulant resistance in wild rodents
- Effect of lycopene and beta-carotene on peroxynitrite-mediated cellular modifications.
- Induction of cytochrome P450-1A by the equine estrogen equilenin, a new endogenous aryl hydrocarbon receptor ligand
- Effect of components of green tea extracts, caffeine and catechins on hepatic drug metabolizing enzyme activities and mutagenic transformation of carcinogens
- Lycopene and beta-carotene ameliorate catechol estrogen-mediated DNA damage
- Antigenotoxic effect of Pleurotus cornucopiae extracts on the mutagenesis of Salmonella typhimurium TA 98 elicited by benzo［a］pyrene and oxidative DNA lesions in V 79 hamster lung cells
- P7-30 Differences of warfarin hydroxylation and vitamin K epoxide reduction between warfarin resistant and sensitive rats(Rattus rattus)(IMMUNE AND ALLERGIC SYSTEM/KIDNEYS AND URINARY EXCRETION SYSTEM/CYTOTOXICITY/OTHERS-1)(GENERAL SESSION BY POSTER PRESE
- Iodine intake as a possible cause of discontinuous decline in sperm counts : A re-evaluation of historical and geographic variation in semen quality
- The effects of antibacterial agent furazolidone and its metabolites on the liver drug metabolizing enzyme system in chicken and rat. (DRUG METABOLISM) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- O12-03 Intracellular dynamics of an endogenous dopaminergic neurotoxin, norsalsolinol, in PC12 cells
- Environmental monitoring by Cytochrome P450:Alterations of monooxygenase activities in Eriocheir japonicus in response to water pollution.
- Application of FT-IR and ESR spectroscopic techniques to the study of CCl_4-induced peroxidation in rat liver microsomes
- Accumulation of diacylglycerol induced by CCl_4-derived radicals in rat liver membrane and its inhibition with radical trapping reagent : FT-IR spectroscopic and HPLC chromatographic observations
- 22D-10-3 Infrared Spectroscopic Study on The Mechanism of CCl_4 Toxicity toward Membrane Phospholipids from Rat Liver.
- STRUCTURE-ACTIVITY RELATIONSHIP IN INDUCTION OF CYTOCHROME P-448 BY LIPOPHILIC AZO DYES AND ITS REGULATION WITH Ah LOCUS
- Morphological Features and Blood Parameters of Weddell Seal (Leptonychotes weddellii) Mothers and Pups during the Breeding Season(Physiology)
- Downregulation of male-specific cytochrome P450 by profenofos
- EFFECT OF 1-m-TOLUENEAZO-2-NAPHTHOL ON HEPATIC DRUG METABOLISM. II. INDUCTION OF UDP-GLUCURONYLTRANSFERASE
- EFFECT OF 1-m-TOLUENEAZO-2-NAPHTHOL ON HEPATIC DRUG METABOLISM. I. INDUCTION OF CYTOCHROME P-448
- INDUCTION OF HEPATIC DRUG METABOLISM BY VARIOUS AZO COMPOUNDS : THE STRUCTURE ACTIVITY RELATIONSHIP
- O11-05 Induction of CYP1A1 by Equine Estrogen, Equilenin
- Generation of OH Radical in the Liver from Wilson's Disease Model, LEC Rats.
- Expression and Characterization of Dog CYP2D15 Using Baculovirus Expression System^1
- PURIFICATION AND CHARACTERIZATION OF A DOG HEPATIC CYTOCHROME P-450 ISOZYME CATALYZING β-BLOCER HYDROXYLATION
- Testicular toxicity of profenofos in matured male rats
- Effect of reactive oxygen species on fulminant hepatitis and subsequent hepatocellular carcinoma in LEC rats and the mechanism of generation of reactive oxygen species
- EVIDENCE OF PARTIAL INVOLVEMENT OF P-450 2D IN MUTAGENIC ACTIVATION OF BENZO(a)PYRENE IN LIVER S-9 FRACTION FROM UNTREATED RATS
- Alterations in Activation and Deactivation of Mutagens in Aging Rat Liver
- ALTERED XENOBIOTICS METABOLIZING CAPACITY DURING SPONTANEOUS DEVELOPMENT OF FULMINANT HEPATITIS AND SUBSEQUENT HEPATOCELLULAR CARCINOMAS IN LEC RATS OF BOTH GENDERS
- 202 CYTOCHROME P-450 BTL (CYP2D SUBFAMILY ISOZYME) METABOLICALLY ACTIVATES CIGARETTE SMOKE EXTRACT IN RAT LlVER S-9
- MECHANISM OF ALTERATIONS OF NON-LINEARITY IN HEPATIC FIRST-PASS METABOLISM OF PROPRANOLOL : ALTERATIONS IN THE RELATIVE ABUNDANCE OF CYTOCHROME P-450 ISOZYMES IN THE LIVER MICROSOMES IN RELATION TO THE ORGAN-LEVEL METABOLIC ACTIVITIES
- STRAIN DIFFERENCES IN NONLINEAR FIRST-PASS METABOLISM IN RATS
- AN APPLICATION OF NON-IDEAL FLOW MODEL WITH MEMBRANE TRANSPORT FOR HEPATIC DRUG ELIMINATION
- MECHANISM OF LIPOPHILIC AZO DYE-INDUCED PREVENTION OF CHEMICAL CARCINOGENESIS
- "PARALLEL PATHWAY INTERACTION"IN NONLINEAR DISPOSITION OF IMIPRAMINE AND ITS ACTIVE METABOLITE, DESIPRAMINE
- REGIO- AND OPTICAL ISOMER-SELECTIVITY OF PURIFIED CYTOCHROMES P-450 IN PROPRANOLOL METABOLISM
- NONLINEAR PHARMACOKINETICS OF LIDOCAINE AND ITS METABOLITES IN RELATION TO MULTIPLE SPECIES OF CYTOCHROME P-450
- FUNCTIONAL FEMINIZATION OF MALE RAT LIVER WITH OLD AGE
- ALTERATION OF RELATIVE ABUNDANCE OF HEPATIC MICROSOMAL CYTOCHROME P-450 ISOZYMES AND MICROSOMAL DRUG METABOLIZING ENZYME ACTIVITIES
- AGE-ASSOCIATED CHANGE IN HEPATIC MICROSOMAL DRUG METABOLIZING ENZYME ACTIVITIES
- LIDOCAINE-LIDOCAINE METABOLITE INTERACTIONS IN THEIR METABOLISM
- The CYP1D subfamily of genes in mammals and other vertebrates.
- Pneumoretroperitoneum, Pneumomediastinum, Pneumopericardium, and Subcutaneous Emphysema Complicating Sigmoidoscopy : Report of a Case
- Archetype JC virus efficiently propagates in kidney-derived cells stably expressing HIV-1 Tat
- Inhibitory effect of serotonin antagonists on JC virus propagation in a carrier culture of human neuroblastoma cells
- Involvement of cell membrane factors in JC virus infection
- Metabolic Alkalosis due to Feeding Chicks in Breeding Adélie Penguins Pygoscelis adeliae under Natural Conditions
- Efficient propagation of progressive multifocal leukoencephalopathy-type JC virus in COS-7-derived cell lines stably expressing Tat protein of human immunodeficiency virus type 1
- The genetic mechanisms of warfarin resistance in Rattus rattus found in the wild in Japan