EVIDENCE OF PARTIAL INVOLVEMENT OF P-450 2D IN MUTAGENIC ACTIVATION OF BENZO(a)PYRENE IN LIVER S-9 FRACTION FROM UNTREATED RATS

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概要

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• In order to clarify which species of cytochrome P-450 is involved in activation of benzo(a)pyrene (BP) in untreated rat liver, strain and sex differences in the ability of rat liver 9000 g supernatant (S-9) to mutagenically activate BP was investigated using Ames test. The numbers of histidine revertants in Ames test after pre-incubation of TA 98 strain of Salmonella typhimurium and BP with liver S-9 from male rats were markedly higher than those obtained using female rats. In addition, a marked strain difference (Wistar>DA) in the ability of liver S-9 from Wistar and DA rats to activate BP was observed. Antibody against cytochrome P-450 2D inhibited up to 50% of the revertant formation by the activation of BP with liver S-9 from male Wistar rats. These results indicate the partial involvement of cytochrome P-450 2D subfamily as well as cytochrome P-450 species specific to male rats in activation of BP to ultimate mutagen in untreated rat liver.

• 日本トキシコロジー学会の論文
• 1994-11-30

著者

• Fujita Shoichi

  Department Of Biopharmaceutics Faculty Of Pharmaceutical Sciences Chiba University

• Masuda M

  Laboratory Of Toxicology Graduate School Of Veterinary Medicine Hokkaido University

• MASUDA Makihiko

  Department of Toxicology, Faculty of Veterinary Medicine, Hokkaido University

• KAZUSAKA Akio

  Department of Toxicology, Faculty of Veterinary Medicine, Hokkaido University

• NUKUZUMA Chiyoko

  Department of Toxicology, Faculty of Veterinary Medicine, Hokkaido University

• Fujita Shoichi

  Department Of Biopharmaceutics Faculty Of Phamaceutical Sciences Chiba University

• Fujita Shoichi

  Laboratory Of Toxicology Graduate School Of Veterinary Medicine Hokkaido University

• Nukuzuma Chiyoko

  Department Of Toxicology Faculty Of Veterinary Medicine Hokkaido University

• Nukuzuma Chiyoko

  Department Of Pathology Hokkaido University School Of Medicine

• Nukuzuma Chiyoko

  Department Of Microbiology Kobe Institute Of Health

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