EFFECT OF 1-m-TOLUENEAZO-2-NAPHTHOL ON HEPATIC DRUG METABOLISM. II. INDUCTION OF UDP-GLUCURONYLTRANSFERASE
スポンサーリンク
概要
- 論文の詳細を見る
Effect of a potent cytochrome P-448 inducer, 1-m-tolueneazo-2-naphthol (m-TAN) on hepatic microsomal UDP-glucuronyl-transferase (UDPGT) activity was studied. The UDPGT activity reached the maximum level on the fifth day after either a single injection or consecutive daily administrations. The UDPGT activities towards p-nitrophenol, 1-naphthol and chloramphenicol were increased up to 6,2.5 and 1.8 folds of control levels respectively, in microsomes from m-TAN treated rats. 3-Methylcholanthrene, on the other hand, caused 4 and 2 fold increase in UDPGT activities towards p-nitrophenol and 1-naphthol respectively, but did not cause significant increase in UDPGT activity towards chloramphenicol. It is concluded that m-TAN is a new, potent inducer of UDPGT activity with its potency exceeding that of 3-methylcholanthrene and the pattern of induction, a little different from that of 3-methylcholanthrene.
- 社団法人日本薬学会の論文
著者
-
Fujita Shoichi
Department Of Biopharmaceutics Faculty Of Pharmaceutical Sciences Chiba University
-
Fujita Shoichi
Department Of Biopharmacy Meiji College Of Pharmacy:(current Address) Department Of Biopharmaceutics
-
ADACHI SHIGERU
Department of Biopharmacy, Meiji College of Pharmacy
-
UESUGI TAKASHI
Department of Biopharmacy, Meiji College of Pharmacy
-
Fujita Shoichi
Department Of Biopharmaceutics Faculty Of Phamaceutical Sciences Chiba University
-
Uesugi Takashi
Department Of Biopharmacy Meiji College Of Pharmacy
-
Uesugi Takashi
Department Of Biopharmacy Meiji Coll. Of Pharmacy
-
Adachi Shigeru
Department Of Biopharmacy Meiji College Of Pharmacy
関連論文
- STRUCTURE-ACTIVITY RELATIONSHIP IN INDUCTION OF CYTOCHROME P-448 BY LIPOPHILIC AZO DYES AND ITS REGULATION WITH Ah LOCUS
- EFFECT OF 1-m-TOLUENEAZO-2-NAPHTHOL ON HEPATIC DRUG METABOLISM. II. INDUCTION OF UDP-GLUCURONYLTRANSFERASE
- EFFECT OF 1-m-TOLUENEAZO-2-NAPHTHOL ON HEPATIC DRUG METABOLISM. I. INDUCTION OF CYTOCHROME P-448
- INDUCTION OF HEPATIC DRUG METABOLISM BY VARIOUS AZO COMPOUNDS : THE STRUCTURE ACTIVITY RELATIONSHIP
- Dependency of Boron Doping Efficiency on Hydrogen Flow Rate in Hydro-Fluorinated Amorphous Silicon
- Properties of Hydro-Fluorinated Amorphous Silicon-Carbide Produced by Intermediate Species SiF_2
- The Staebler-Wronski Effect in Hydro-Fluorinated Amorphous Silicon Prepared Using the Intermediate Species SiF_2
- Photoconductive Amorphous Silicon-Carbide Produced by Intermediate Species SiF_2 and CF_4 Mixture
- Effect of reactive oxygen species on fulminant hepatitis and subsequent hepatocellular carcinoma in LEC rats and the mechanism of generation of reactive oxygen species
- EVIDENCE OF PARTIAL INVOLVEMENT OF P-450 2D IN MUTAGENIC ACTIVATION OF BENZO(a)PYRENE IN LIVER S-9 FRACTION FROM UNTREATED RATS
- Alterations in Activation and Deactivation of Mutagens in Aging Rat Liver
- ALTERED XENOBIOTICS METABOLIZING CAPACITY DURING SPONTANEOUS DEVELOPMENT OF FULMINANT HEPATITIS AND SUBSEQUENT HEPATOCELLULAR CARCINOMAS IN LEC RATS OF BOTH GENDERS
- 202 CYTOCHROME P-450 BTL (CYP2D SUBFAMILY ISOZYME) METABOLICALLY ACTIVATES CIGARETTE SMOKE EXTRACT IN RAT LlVER S-9
- MECHANISM OF ALTERATIONS OF NON-LINEARITY IN HEPATIC FIRST-PASS METABOLISM OF PROPRANOLOL : ALTERATIONS IN THE RELATIVE ABUNDANCE OF CYTOCHROME P-450 ISOZYMES IN THE LIVER MICROSOMES IN RELATION TO THE ORGAN-LEVEL METABOLIC ACTIVITIES
- STRAIN DIFFERENCES IN NONLINEAR FIRST-PASS METABOLISM IN RATS
- AN APPLICATION OF NON-IDEAL FLOW MODEL WITH MEMBRANE TRANSPORT FOR HEPATIC DRUG ELIMINATION
- MECHANISM OF LIPOPHILIC AZO DYE-INDUCED PREVENTION OF CHEMICAL CARCINOGENESIS
- "PARALLEL PATHWAY INTERACTION"IN NONLINEAR DISPOSITION OF IMIPRAMINE AND ITS ACTIVE METABOLITE, DESIPRAMINE
- REGIO- AND OPTICAL ISOMER-SELECTIVITY OF PURIFIED CYTOCHROMES P-450 IN PROPRANOLOL METABOLISM
- NONLINEAR PHARMACOKINETICS OF LIDOCAINE AND ITS METABOLITES IN RELATION TO MULTIPLE SPECIES OF CYTOCHROME P-450
- FUNCTIONAL FEMINIZATION OF MALE RAT LIVER WITH OLD AGE
- ALTERATION OF RELATIVE ABUNDANCE OF HEPATIC MICROSOMAL CYTOCHROME P-450 ISOZYMES AND MICROSOMAL DRUG METABOLIZING ENZYME ACTIVITIES
- AGE-ASSOCIATED CHANGE IN HEPATIC MICROSOMAL DRUG METABOLIZING ENZYME ACTIVITIES
- LIDOCAINE-LIDOCAINE METABOLITE INTERACTIONS IN THEIR METABOLISM
- Pneumoretroperitoneum, Pneumomediastinum, Pneumopericardium, and Subcutaneous Emphysema Complicating Sigmoidoscopy : Report of a Case
- Occult hepatitis B virus infection as a risk factor for hepatocellular carcinoma in patients with chronic hepatitis C in whom viral eradication fails
- STEREOSELECTIVE GLUCURONIDATION AND SULFATION OF CHLORAMPHENICOL ENANTIOMERS IN RATS AND GUINEA PIGS
- Initial Intraorgan Formation of Mercapturic Acid
- Thermal Stratification Phenomena in a Tower-Style Tank for Simultaneous Storing of Warm and Ice