EFFECT OF 1-m-TOLUENEAZO-2-NAPHTHOL ON HEPATIC DRUG METABOLISM. I. INDUCTION OF CYTOCHROME P-448
スポンサーリンク
概要
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Treatment of rats with 1-m-tolueneazo-2-naphthol (mTAN) caused marked increase in liver weight, microsomal 7-ethoxycoumarin O-deethylase activity and cytochrome P-450 content, with 2 nm hypochromic shift in CO difference spectrum. It decreased NADPH-cytochrome c reductase and aminopyrine N-demethylase activities. Treatment of 3-methylcholanthrene nonresponsive DBA/2 strain of mice with this azo compound resulted in a limited (1.5 fold) induction of cytochrome P-450 compared to 2.5 fold induction in responsive C57BL/6 strain of mice. The major species of liver microsomal P-450 from m-TAN treated rats was purified. This species of P-450 has a Solet peak at 416 nm in the absolute oxidized sprectrum, 410 nm in the reduced spectrum and 447 nm in the spectrum of ferrous P-450-CO complex. This species of P-450 is spectrally indistinguishable from cytochrome P-448 induced by 3-methylcholanthrene. As an inducer of cytochrome P-450,m-TAN is similar to 3-methylcholanthrene with its potency equals to or exceeding that of 3-methylcholanthrene. It differs in that it causes marked increase in liver weight and decrease in NADPH-cytochrome c reductase activity.
- 社団法人日本薬学会の論文
著者
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Fujita Shoichi
Department Of Biopharmaceutics Faculty Of Pharmaceutical Sciences Chiba University
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Fujita Shoichi
Department Of Biopharmacy Meiji College Of Pharmacy:(current Address) Department Of Biopharmaceutics
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ADACHI SHIGERU
Department of Biopharmacy, Meiji College of Pharmacy
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UESUGI TAKASHI
Department of Biopharmacy, Meiji College of Pharmacy
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Fujita Shoichi
Department Of Biopharmaceutics Faculty Of Phamaceutical Sciences Chiba University
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Uesugi Takashi
Department Of Biopharmacy Meiji College Of Pharmacy
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Uesugi Takashi
Department Of Biopharmacy Meiji Coll. Of Pharmacy
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Adachi Shigeru
Department Of Biopharmacy Meiji College Of Pharmacy
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