Testicular toxicity of profenofos in matured male rats
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概要
- 論文の詳細を見る
To investigate the effect of the phosphorothoate insecticide profenofos on male specific gene expression on rat testis, 16-week-old Wistar rats were orally administered at dose of 17.8 mg/kg twice weekly for 65 days. Gene expression in the testes was monitored by DNA microarray analysis and real-time RT-PCR, which revealed that genes related to steroidogenesis including cytochrome P450 17A1 (CYP17A1), steroidogenic acute regulatory protein (StAR) and CYP11A1 were significantly increased. Besides the testes were histopathologicaly examined, which revealed testicular destruction and degeneration represented by a layer of columnar epithelium, oedematous changes surrounding the seminiferous tubules besides vacuolated spermatogonial cells and more elongated Leydig cells. These data suggest that profenofos considered as one of the male reproductive toxicants. Furthermore, we propose that the above three steroidogenic-related genes and the gene of acrosomal reaction as potential biomarkers of testicular toxicity.
- Springerの論文
著者
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Ishizuka Mayumi
北海道大学 獣医学研究科毒性学
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Ishizuka Mayumi
北海道大学 獣医学研究科環境獣医科学講座毒性学
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Ishizuka Mayumi
北海道大学 獣医学研究科
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坂本 健太郎
北海道大学大学院獣医学研究科毒性学教室
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Ishizuka Mayumi
Hokkaido Univ. Sapporo Jpn
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Fujita S
Laboratory Of Toxicology Department Of Environmental Veterinary Sciences Graduate School Of Veterina
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Fujita Shoichi
北海道大学 獣医研究 環境獣医
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Sakamoto Kentaro
Laboratory Of Toxicology Department Of Environmental Veterinary Sciences Graduate School Of Veterina
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Sakamoto Kentaro
Laboratory Of Toxicology Department Of Environmental Veterinary Science School Of Veterinary Medicin
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Sakamoto Kentaro
Department Of Environmental Veterinary Sciences Graduate School Of Veterinary Medicine Hokkaido Univ
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Ishizuka Mayumi
Laboratory Of Toxicology Graduate School Of Veterinary Medicine Hokkaido University
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Fujita Shoichi
Laboratory Of Toxicology Graduate School Of Veterinary Medicine Hokkaido University
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Ishizuka Mayumi
Laboratory Of Toxicology Department Of Environmental Veterinary Sciences Graduate School Of Veterina
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Sakamoto Kentaro
Hokkaido Univ. Sapporo
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