Molecular Cloning of Novel Cytochrome P450 1A Genes from Nine Japanese Amphibian Species

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概要

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• Novel cytochrome P450 1A (CYP1A) cDNA fragments were isolated from the liver of nine Japanese amphibian species using reverse transcription polymerase chain reaction (RT-PCR). Degenerate PCR primers were used to amplify 122-bp fragments of CYP1A cDNAs. Construction of a phylogenetic tree revealed that urodele and anuran amphibians formed two branches. Within the anuran species, three branches were formed: 1) Ranidae and Rhacophoridae, 2) Bufo japonicus formosus and Hyla japonica, and 3) Xenopus laevis. The cDNA nucleotide sequence of these CYP1A fragments showed identities ranging 72-98% (all), 72-78% (Anura vs. Urodela), 75 to 98% (Anura), 81% (Urodela), 74-80% (Xenopus laevis vs. nine Japanese amphibians).

• 社団法人　日本獣医学会の論文

著者

• FUJITA Shoichi

  Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Graduate School of Veteri

• Ishizuka Mayumi

  Laboratory Of Toxicology Department Of Environmental Veterinary Sciences Graduate School Of Veterina

• Sakamoto Kentaro

  Laboratory of Toxicology, Graduate School of Veterinary Medicine, Hokkaido University

• Ishizuka Mayumi

  Laboratory Of Toxicology

• Sakamoto Kentaro

  Laboratory Of Toxicology Department Of Environmental Veterinary Science School Of Veterinary Medicin

• Fujita Shoichi

  Laboratory Of Toxicology

• NAKAYAMA Shouta

  Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Graduate School of Veteri

• TANAKA-UENO Tomoko

  Center for Liberal Arts, Meiji Gakuin University

• SAKAMOTO Kentaro

  Laboratory of Physiology, Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University

• SAKAMOTO Kentaro

  Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University

• FUJITA Shoichi

  Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University

• NAKAYAMA Shouta

  Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Kita 18, Nishi 9, Sapporo 060–0818, Japan

• NAKAYAMA Shouta

  Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University

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