Effect of components of green tea extracts, caffeine and catechins on hepatic drug metabolizing enzyme activities and mutagenic transformation of carcinogens
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概要
- 論文の詳細を見る
Green tea contains catechins and caffeine as major constituents. Treatment of rats with green tea (2.5% w/v) significantly increased 7-ethoxycoumarin O-deethylase (7-ECOD), caffeine N-1demethylase (CN1D) and UDP-glucuronyltransferase (UGT) activities. Treatment with caffeine similarly activated CYP1A2 and related monooxygenases as well as UGT, while treatment with catechins induced UGT activity but not 7-ECOD or CN1D activity. Numbers of benzo［a］pyrene(BP)-induced revertant colonies in an Ames test (mutation assay) with S. typhimurium TA98 as the test strain were markedly larger when BP was preincubated with the liver S-9 (9000×g supernatant of liver homogenate) from green tea-treated rats than when preincubated with that from control rats. In a modified Ames assay system in which UGT was activated by the addition of UDP-glucuronic acid to the preincubation mixture, the numbers of revertant colonies in the assay using liver S-9 from green teatreated rats decreased to a similar level to that in the assay using S-9 from controls. The acceleration of two enzymatic reactions may contribute to the rapid elimination of BP; the first step, the formation of a metabolic intermediate (which is mutagenic) by CYP1A2 and the second, the conjugation of active metabolic intermediates by UGT. We speculated that green tea can reduce the amount of time carcinogens reside in the body and the chance that body tis-prodsues will be exposed to active metabolites of carcinogens thorough rapid elimination due to the simultaneous induction of CYP1A2 and UGT activities.
- 北海道大学の論文
- 2005-02-28
著者
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KAZUSAKA Akio
Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Graduate School of Veteri
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FUJITA Shoichi
Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Graduate School of Veteri
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Ishizuka Mayumi
北海道大学 獣医学研究科毒性学
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Ishizuka Mayumi
北海道大学 獣医学研究科環境獣医科学講座毒性学
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Ishizuka Mayumi
北海道大学 獣医学研究科
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Ishizuka Mayumi
Laboratory Of Toxicology Department Of Environmental Veterinary Sciences Graduate School Of Veterina
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NIKAIDOU Satoshi
Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Gradute School of Veterin
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MAEDA Yutaka
Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Gradute School of Veterin
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KARA Yukihiko
Food Research Laboratories, Mitsui Norin Co. Ltd.,
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Ishizuka Mayumi
Hokkaido Univ. Sapporo Jpn
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Fujita S
Laboratory Of Toxicology Department Of Environmental Veterinary Sciences Graduate School Of Veterina
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Fujita Shoichi
北海道大学 獣医研究 環境獣医
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Kara Yukihiko
Food Research Laboratories Mitsui Norin Co. Ltd.
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Ishizuka Mayumi
Laboratory Of Toxicology
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Kazusaka Akio
Laboratory Of Toxicology Department Of Environmental Veterinary Sciences
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Nikaidou Satoshi
Laboratory Of Toxicology Department Of Environmental Veterinary Sciences Gradute School Of Veterinar
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Ishizuka Mayumi
Laboratory Of Toxicology Graduate School Of Veterinary Medicine Hokkaido University
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Fujita Shoichi
Laboratory Of Toxicology
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Fujita Shoichi
Laboratory Of Toxicology Graduate School Of Veterinary Medicine Hokkaido University
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Hara Yukihiko
Food Research Institute Mitsui Norin Co.
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Ishizuka Mayumi
Laboratory Of Toxicology Department Of Environmental Veterinary Sciences Graduate School Of Veterina
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Kazusaka Akio
Lavoratory Of Toxicology Graduate School Of Veterinary Medicine Hokkaido University
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Maeda Yutaka
Laboratory Of Toxicology Department Of Environmental Veterinary Sciences School Of Veterinary Medici
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Kazusaka Akio
Graduate School Of Vet. Med. Hokkaido Univ.
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