Apoptosis-inducing Activity of Polyphenol Compounds Derived from Tea Catechins in Human Histiolytic Lymphoma U937 Cells

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概要

• 論文の詳細を見る

• Polyphenolic compounds derived from tea catechins were examined for apoptosis-inducing activity in human histiolytic lymphoma U937 cells. (-)-Epigallocatechin gallate, theasinensin D, compound OH-5,theaflavin, and theaflavin digallate induced apoptosis as evidenced by DNA ladder formation, its inhibition by a caspase inhibitor, and chromatin condensation. Theasinensin D was the most potent inducer and the data suggest the importance of the number and three dimensional localization of their phenolic groups in this activity. These apoptosis-inducible compounds may be useful as a cancer chemopreventive and chemotherapeutic agent.

• 社団法人日本農芸化学会の論文
• 1999-03-23

著者

• HARA YUKIHIKO

  Food Research Laboratories, Mitsui Norin Co., Ltd.

• NAKAMURA Yoshiyuki

  School of Pharmaceutical Sciences, University of Shizuoka

• Nakamura Yoshimasa

  Division Of Applied Life Sciences Graduate School Of Agriculture Kyoto University

• MIYASE Toshio

  School of Pharmaceutical Sciences, University of Shizuoka

• Hara Yukihiko

  Food Research Institute Mitsui Norin Co. Ltd.

• Miyase T

  School Of Pharmaceutical Sciences University Of Shizuoka

• 宮瀬 敏男

  Department Of Pharmacognosy School Of Pharmaceutical Sciences

• Miyase Toshio

  School Of Pharmaceutical Science University Of Shizuoka

• Aoyagi Y

  Niigata Univ. School Of Medicine Niigata Jpn

• Aoyagi Yutaka

  Department Of Third Internal Medicine Niigata University School Of Medicine

• Aoyagi Yutaka

  Department Of Radiology Tokyo Dental College

• Aoyagi Yutaka

  Tokyo University Of Pharmacy And Life Sciences School Of Pharmacy

• SANO Mitsuaki

  School of Pharmaceutical Sciences, University of Shizuoka

• ISEMURA Mamoru

  School of Food and Nutritional Sciences and Center of Excellence for the 21st Century, University of

• Saeki K

  Department Of Hematology Research Institute International Medical Center Of Japan

• Sano Mitsuaki

  School Of Pharmaceutical Sciences University Of Shizuoka

• Aoyagi Y

  Tokyo University Of Pharmacy And Life Sciences School Of Pharmacy

• 伊勢村 護

  Cellular Biochemistry School Of Food And Nutritional Sciences University Of Shizuoka

• Isemura Mamoru

  Laboratory Of Cellular Biochemistry Graduate School Of Nutritional And Environmental Sciences Univer

• SAEKI Kouichi

  School of Food and Nutritional Sciences University of Shizuoka

• Aoyagi Yutaka

  Department Of Gastroenterology And Hepatology Niigata University Graduate School Of Medical And Dent

• Hara Yukihiko

  Food Research Institute Mitsui Norin Co.

• SANO Mitsuaki

  School of Pharmaceutical Science, University of Shizuoka

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