Antitumor-Promoting Constituents from Dioscorea bulbifera L. in JB6 Mouse Epidermal Cells

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概要

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• An antitumor-promoting effect was found in the extracts/ingredients of a plant used as a traditional medicine in mainland China, using the neoplastic transformation assay of mouse epidermal JB6 cell lines. The ethyl acetate soluble fraction of 75 % ethanol extract of the rhizomes of Dioscorea bulbifera L. showed an inhibitory effect against the tumor promotion of JB6 (Cl 22 and Cl 41) cells induced by a promoter, 12-O-tetrade-canoylphorbol-13-acetate (TPA). Further investigation on the constituents of the EtOAc fraction from the rhizomes revealed the chemical structure to be kaempferol-3,5-dimethyl ether (1), caryatin (2), (+)-catechin (3), myricetin (4), quercetin-3-O-galactopyranoside (5), myricetin-3-O-galactopyranoside (6), myricetin-3-O-glucopyranoside (7) and diosbulbin B (8). Constituent antitumor-promoting activities were also examined in the same way. Compounds 1-7, characterized as fiavonoids with the two hydroxyl groups at C-7 and C-4', showed the most potent inhibitory effect, but there seemed to be differences in the inhibitory effect between fiavonol aglycones and fiavonol glycosides. Compared with (-)-epicatechin, (+)-catechin exhibited much stronger inhibitory activity which suggested that chemical stereo structures of compounds affect the efficiency of inhibition. Compound 8 showed moderate activity. The constituents with antitumor-promoting activity from this plant are reported for the first time.

• 公益社団法人日本薬学会の論文
• 2002-09-01

著者

• KAWAHARA Nobuo

  National Institute of Health Sciences

• NAKAMURA Yoshiyuki

  School of Pharmaceutical Sciences, University of Shizuoka

• KUROYANAGI Masanori

  School of Bioresources, Hiroshioma Prefectural University

• WU Lijun

  Department of Phytochemistry, Shenyang Pharmaceutical University

• Wu Lijun

  Department Of Traditional Chinese Medicines Shenyang Pharmaceutical University

• Wu Lijun

  Materials Science Division Brookhaven National Laboratory

• Gao H

  School Of Traditional Chinese Medicines Shenyang Pharaceutical University

• Gao Hui

  School Of Traditional Chinese Medicines Shenyang Pharmaceutical University

• Kuroyanagi M

  Fac. Of Pharmaceutical Sciences At Kagawa Campus Tokushima Bunri Univ.

• Wu Li-jun

  School Of Traditional Chinese Materia Medica Shenyang Pharmaceutical University

• GAO Huiyuan

  Department of Traditional Chinese Medicines, Shenyang Pharmaceutical University

• YASUNO Takeaki

  School of Pharmaceutical Sciences, University of Shizuoka

• Nakamura Yoshiyuki

  Chugoku National Agricultural Experiment Station

• Nakamura Yoshiyuki

  Molecular Function Laboratory National Food Research Institute Ministry Of Agriculture Farestry And

• Nakamura Y

  Tohoku Pharmaceutical Univ. Sendai Jpn

• Kawahara N

  National Institute Of Health Sciences

• Kuroyanagi Masanori

  Fac. Of Pharmaceutical Sciences At Kagawa Campus Tokushima Bunri Univ.

• Yasuno Takeaki

  School Of Pharmaceutical Sciences University Of Shizuoka

• 川原 信夫

  National Institute Of Health Sciences

• NAKAMURA Yoshiyuki

  Nat. Food Res. Inst.

• Nakamura Y

  School Of Bioresources Hiroshima Prefectural Univ.

• Kuroyanagi Masanori

  School Of Bioresources Hiroshima Prefectural University

• Kimura Mariko

  Fac. Of Food Culture Dep. Of Nutrition Kurashiki Sakuyo Univ.

• Wu Lijun

  School Of Traditional Chinese Materia Medica Shenyang Pharmaceutical University

• Kawahara Nobuo

  Tsukuba Div. Res. Center For Medicinal Plant Resources National Inst. Of Biomedical Innovation

• Kawahara Nobuo

  National Inst. Health Sci. Tokyo Jpn

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