Antitumor-Promoting Constituents from Chaenomeles sinensis KOEHNE and Their Activities in JB6 Mouse Epidermal Cells

スポンサーリンク

概要

• 論文の詳細を見る

• Primary screening of antitumor-promoting activity using soft agar colony assays with JB6 cells was employed to isolate 22 compounds from Chaenomeles sinensis KOEHNE. These compounds were lyoniresinol-2a-ο-α-L-rhamnopyranoside (1), lyoniresinol-2a-ο-β-D-glucopyranoside (2), aviculin (3), betulinic acid (4), betulin (5), 3-ο-(E)-p-coumaroylbetulin (6), 3-ο-(E)-caffeoylbetulin (7), 3-ο-(Z)-p-coumaroylbetulin (8), 3-ο-(E)-caffeoyllupeol (9), alphitolic acid (10), sorbikortal II (11), tormentic acid (12), euscaphic acid (13), corosolic acid (14), maslinic acid (15), erythrodiol (16), 1-β-D-glucopyranosyloxy-3,4,5-trimethoxybenzene (17), avicularin (18), 7-ο-β-D-glucopyranosylkaempferol (19), 5-ο-β-D-glucopyranosylgenistein (20), 7-ο-β-D-glucopyranosylgenistein (21), epicatechin (22), and β-sitosterol (23) and were identified using spectral data such as MS, ^1H- and ^<13>C-NMR. Compound 1, having a rhamnosyl group, showed greater activity than 2, having a glucosyl group, and 3, which was a bis-demethoxy derivative of 1. Betulinic acid (4), having a C-28 carboxyl group, 3-ο-(E)-caffeoylbetulin (7), and tormentic acid (12) showed more potent activity than betulin (5), which has a C-28 hydroxymethyl group.

• 公益社団法人日本薬学会の論文
• 2003-11-01

著者

• UMEHARA Kaoru

  School of Pharmaceutical Sciences, University of Shizuoka

• KAWAHARA Nobuo

  National Institute of Health Sciences

• NAKAMURA Yoshiyuki

  School of Pharmaceutical Sciences, University of Shizuoka

• KUROYANAGI Masanori

  School of Bioresources, Hiroshioma Prefectural University

• WU Lijun

  Department of Phytochemistry, Shenyang Pharmaceutical University

• Wu Lijun

  Department Of Traditional Chinese Medicines Shenyang Pharmaceutical University

• Wu Lijun

  Materials Science Division Brookhaven National Laboratory

• Gao H

  School Of Traditional Chinese Medicines Shenyang Pharaceutical University

• Gao Hui

  School Of Traditional Chinese Medicines Shenyang Pharmaceutical University

• Kuroyanagi M

  Fac. Of Pharmaceutical Sciences At Kagawa Campus Tokushima Bunri Univ.

• 梅原 薫

  School of Pharmaceutical Sciences, University of Shizuoka

• Wu Li-jun

  School Of Traditional Chinese Materia Medica Shenyang Pharmaceutical University

• GAO Huiyuan

  Department of Traditional Chinese Medicines, Shenyang Pharmaceutical University

• HARADA Kazunori

  School of Bioresources, Hiroshima Prefectural University

• NAKANE Takahisa

  Tsukuba Medicinal Plant Station, National Institute of Health Sciences

• HIROSAWA Ayako

  School of Pharmaceutical Sciences, University ofShizuoka

• Nakane Takahisa

  Biological Sci. Res. Lab. Lion Corp.

• Nakane Takahisa

  Showa Pharmaceutical Univ.

• Nakamura Yoshiyuki

  Chugoku National Agricultural Experiment Station

• Nakamura Yoshiyuki

  Molecular Function Laboratory National Food Research Institute Ministry Of Agriculture Farestry And

• Nakamura Y

  Tohoku Pharmaceutical Univ. Sendai Jpn

• Kawahara N

  National Institute Of Health Sciences

• Umehara K

  School Of Pharmaceutical Sciences University Of Shizuoka

• Kuroyanagi Masanori

  Fac. Of Pharmaceutical Sciences At Kagawa Campus Tokushima Bunri Univ.

• Hirosawa Ayako

  School Of Pharmaceutical Sciences University Ofshizuoka

• 川原 信夫

  National Institute Of Health Sciences

• 梅原 薫

  School Of Pharmaceutical Sciences University Of Shizuoka

• NAKAMURA Yoshiyuki

  Nat. Food Res. Inst.

• Nakamura Y

  School Of Bioresources Hiroshima Prefectural Univ.

• Harada Kazunori

  School Of Bioresources Hiroshima Prefectural University

• Umehara Kaoru

  School Of Pharmaceutical Sciences University Of Shizuoka

• Kuroyanagi Masanori

  School Of Bioresources Hiroshima Prefectural University

• Kimura Mariko

  Fac. Of Food Culture Dep. Of Nutrition Kurashiki Sakuyo Univ.

• Wu Lijun

  School Of Traditional Chinese Materia Medica Shenyang Pharmaceutical University

• Kawahara Nobuo

  Tsukuba Div. Res. Center For Medicinal Plant Resources National Inst. Of Biomedical Innovation

• Kawahara Nobuo

  National Inst. Health Sci. Tokyo Jpn

• NAKANE Takahisa

  Tsukuba Medicinal Plant Research Station, National Institute of Health Sciences

関連論文

• In Vitro Leishmanicidal Activity of Benzophenanthridine Alkaloids from Bocconia pearcei and Related Compounds
• Production of Sesquiterpene-Type Phytoalexins by Hairy Roots of Hyoscyamus albus Co-treated with Cupper Sulfate and Methyl Jasmonate
• Characterization of the Cytotoxic Activity of Nitric Oxide Generating N-Nitroso Compounds
• Medicinal Flowers. XXVII : New Flavanone and Chalcone Glycosides, Arenariumosides I, II, III, and IV, and Tumor Necrosis Factor-α Inhibitors from Everlasting, Flowers of Helichrysum arenarium
• Medicinal flowers. 28. structures of five new glycosides, everlastosides A, B, C, D, and E, from the flowers of Helichrysum arenarium
• Medicinal Flowers. XXX. Eight New Glycosides, Everlastosides F—M, from the Flowers of Helichrysum arenarium
• Enzymatic preparation of 1-O-hydroxycinnamoyl-β-D-glucoses and their application to the study of 1-O-hydroxycinnamoyl-β-D-glucose-dependent acyltransferase in anthocyanin-producing cultured cells of Daucus carota and Glehnia littoralis
• Isolation and Structural Elucidation of Cyclopentynafil and N-Octylnortadalafil Found in a Dietary Supplement
• Suppressive Effects of S-Methyl Methanethiosulfonate on Promotion Stage of Diethylnitrosamine-initiated and Phenobarbital-promoted Hepatocarcinogenesis Model
• Studies on Constituents from Chamaecyparis pisifera and Antibacterial Activity of Diterpenes
• Simultaneous determination of seven saponins in the roots of Codonopsis lanceolata by liquid chromatography-mass spectrometry
• Rapid identification of triterpenoid saponins in the roots of Codonopsis lanceolata by liquid chromatography-mass spectrometry
• Codonopsis lanceolata Ameliorate Plasma Testosterone Reduction Induced by Immobilization Stress in Middle-Aged Mice
• Codonopsis lanceolata Accelerates Recovery from the Reproductive Dysfunction Induced by Hyperthermic Treatment in Male Mice
• Triterpene Glycosides from the Roots of Codonopsis lanceolata
• Reactive Oxygen Species Mediate Oridonin-Induced HepG2 Apoptosis Through p53, MAPK, and Mitochondrial Signaling Pathways
• Fibroblast Growth Factor-2 Suppresses Oridonin-Induced L929 Apoptosis Through Extracellular Signal-Regulated Kinase-Dependent and Phosphatidylinositol 3-Kinase-Independent Pathway
• Bcl-2 Up-Regulation and P-p53 Down-Regulation Account for the Low Sensitivity of Murine L929 Fibrosarcoma Cells to Oridonin-Induced Apoptosis(Pharmacology)
• Evaluation of the crude drugs by means of colorimeter. Part 6. : Correlation between the color and total polyphenol content of Geranium Herb
• Identification of N-Methyl-4-(3,4-Methylenedioxyphenyl) Butan-2-Amine, Distributed as MBDB
• 2 ガガイモ科及びナス科植物のステロイドとその細胞分化誘導活性(口頭発表の部)
• Cell Differentiation-Inducing Diterpenes from Andrographis paniculata NEES
• Studies on Differentiation-Inducers from Arctium Fructus
• Leishmanicidal Active Constituents from Nepalese Medicinal Plant Tulsi (Ocimum sanctum L.)
• Bioactive Constituents from Chinese Natural Medicines. XIV. New Glycosides of β-Carboline-Type Alkaloid, Neolignan, and Phenylpropanoid from Stellaria dichotoma L. var. lanceolata and Their Antiallergic Activities
• Rearranged Lanostane Triterpenoids from Abies sachalinensis (III)
• Beyerane Derivatives and a Sesquiterpene Dimer from Japanese Cypress : Chamaecyparis obtusa
• Novel Lanostane and Rearranged Lanostane-Type Triterpenoids from Abies sachalinensis-II-
• A New Leishmanicidal Saponin from Brunfelsia grandiflora
• S-Methyl Methanethiosulfonate, Bio-antimutagen in Homogenates of Cruciferae and Liliaceae Vegetables
• Neurite Outgrowth-Promoting Active Constituents of the Japanese Cypress (Chamaecyparis obtusa)
• New Diarylheptanoids from Alnus japonica and Their Antioxidative Activity
• Sesquiterpenes from Curcuma comosa
• Structures of New Sesquiterpenes from Curcuma comosa
• A guanidine derivative from seeds of Plantago asiatica
• Polyphenols and Other Components in the Fractions Prepared from the Infusions of Various Tea Leaves
• Antimicrobial Activity of Tea Extracts on Cariogenic Bacterium (Streptococcus mutans)
• P-517 Leishmanicidal Constituents from Brunfelsia grandiflora
• Tumor Antigen Occurs in N-Glycan of Royal Jelly Glycoproteins : Honeybee Cells Synthesize T-Antigen Unit in N-Glycan Moiety
• Structural Features of N-Glycans Linked to Glycoproteins from Oil Palm Pollen, an Allergenic Pollen(Biochemistry & Molecular Biology)
• Purification and Characterization of 31-kDa Palm Pollen Glycoprotein (Ela g Bd 31 K), Which is Recognized by IgE from Palm Pollinosis Patients(Biochemistry & Molecular Biology)
• Authentication and Chemical Study of Isodonis Herba and Isodonis Extracts
• Malycorins A-C, New Lycopodium Alkaloids from Lycopodium phlegmaria
• Antitumor-Promoting Constituents from Chaenomeles sinensis KOEHNE and Their Activities in JB6 Mouse Epidermal Cells
• Seven Glycosides from Dioscorea bulbifera L
• Antitumor-Promoting Constituents from Dioscorea bulbifera L. in JB6 Mouse Epidermal Cells
• Seven Compounds from Dioscorea bulbifera L.
• p53-Mediated Cell Cycle Arrest and Apoptosis Induced by Shikonin via a Caspase-9-Dependent Mechanism in Human Malignant Melanoma A375-S2 Cells
• A novel shadow-imaging technique to measure charge distribution and lattice displacement
• NITIDASIN, A NOVEL SESTERTERPENOID, FROM THE PERUVIAN FOLK MEDICINE "HERCAMPURI" (GENTIANELLA NITIDA)
• 350-kDa Royal Jelly Glycoprotein (Apisin), Which Stimulates Proliferation of Human Monocytes, Bears the β1-3Galactosylated N-Glycan : Analysis of the N-Glycosylation Site(Biochemistry & Molecular Biology)
• First Evidence for Occurrence of Galβ1-3GlcNAcβ1-4Man Unit in N-Glycans of Insect Glycoprotein : β1-3Gal and β1-4GlcNAc Transferases Are Involved in N-Glycan Processing of Royal Jelly Glycoproteins(Biochemistry & Molecular Biology)
• Antiviral Activity of a Hot Water Extract of Black Soybean against a Human Respiratory Illness Virus(Food & Nutrition Science)
• Occurrence of GalNAcβ1-4GlcNAc Unit in N-Glycan of Royal Jelly Glycoprotein(Biochemistry & Molecular Biology)
• Structural Features of N-Glycans Linked to Royal Jelly Glycoproteins : Structures of high-mannose type, hybrid type, and biantennary type glycans
• Apoptosis-inducing Activity of High Molecular Weight Fractions of Tea Extracts
• Differentiation Inducing Activities of Isocoumarins from Hydrangea Dulcis Folium
• Studies on Differentiation Inducers. VI.Lignan Derivatives from Arctium Fructus. (2)
• P-127 Leishmanicidal constituents from a Myanmar plant Cordia fragrantissima
• Two New Cucurbitacin Glucosides, Opercurins A and B, from the Brazilian Folk Medicine "Buchinha" (Luffa operculata)
• Two Novel Cucurbitacins, Neocucrbitacins A and B, from the Brazilian Folk Medicine "Buchinha" (Luffa operculata)and Their Effect on PEBP2αA and OCIF Gene Expression in a Human Osteoblast-Like Saos-2 Cell Line
• Anti-androgenic Triterpenoids from the Brazilian Medicinal Plant, Cordia multispicata
• A New Secoiridoid Glucoside, Amaronitidin, from the Peruvian Folk Medicine "Hercampuri" (Gentianella nitida)
• A Novel Sesterterpenoid, Nitiol, as a potent Enhancer of IL-2 Gene Expression in a Human T Cell Line, from the Peruvian Folk Medicine"Hercumpuri" (Gentianella nitida)
• Flavonoid glycosides and limonoids from Citrus molasses
• Biotransformation of Benzaldehyde-Type and Acetophenone-Type Derivatives by Pharbitis nil Hairy Roots
• Glucosylation of Phenolic Compounds by Pharbitis nil Hairy Roots : I. Glucosylation of Coumarin and Flavone Derivatives
• Antioxidant Effects of Caesalpinia paraensis Extract on Human Skin Lipid Peroxidation
• The constituents of the roots of Ampelopsis japonica
• Two Phenylpropanoid Glycosides from Neopicrorhiza scrophulariiflora
• Apoptosis-inducing Activity of Polyphenol Compounds Derived from Tea Catechins in Human Histiolytic Lymphoma U937 Cells
• Novel A-Seco-Rearranged Lanostane Triterpenoids from Abies sachalinensis
• 天然ガムベースサンダラック樹脂の主成分の確認
• Bacopasides III-V : Three New Triterpenoid Glycosides from Bacopa monniera
• New Phenylethanoid Glycosides from Bacopa monniera
• Five New Triterpene Saponins, Polygalasaponins XXVIII-XXXII from the Root of Polygala japonica HOUTT.
• Studies on the Constituents of Polygala japonica HOUTT. III. Structures of Polygalasaponins XX-XXVII
• STUDIES ON DIFFERENTIATION INDUCERS FROM PLANTS
• PC84 Isolation of Differentiation Inducers from Plant Sources
• Cell Differentiation Inducers and Antiandrogenic Active Compounds from Zingiberis Rhizoma
• Nine New Triterpene Saponins, Polygalasaponins XXXIII-XLI from the Roots of Polygala fallax HEMSL.
• Cell Differentiation Inducing Steroids from Withania somnifera L. (DUN.)
• Phytoestrogens from Aspalathus linearis(Pharmacognosy)
• Umbelliferone Released from Hairy Root Cultures of Pharbitis nil Treated with Copper Sulfate and Its Subsequent Glucosylation
• Prolyl Endopeptidase Inhibitors from the Roots of Lindera strychnifolia F. VILL
• Anthocyanin-dimer synthesis in suspension-cultured cells of mutant line of carrot
• Determination of (R)-Xanthoanthrafil, a Phosphodiesterase-5 Inhibitor, in a Dietary Supplement Promoted for Sexual Enhancement
• A New Antifungal Macrolide, Eushearilide, Isolated from Eupenicillium shearii
• Salt-Adaptation of Tobacco BY2 Cells Induces Change in Glycoform of N-Glycans : Enhancement of Exo- and Endo-Glycosidase Activities by Salt-Adaptation
• Identification of a Cannabinoid Analog as a New Type of Designer Drug in a Herbal Product(Communications to the Editor)
• Intracellular and extracellular free N-glycans produced by plant cells : occurrence of unusual plant complex-type free N-glycans in extracellular spaces
• Murine metabolism and absorption of lancemaside A, an active compound in the roots of Codonopsis lanceolata
• A New Acylated Flavonol Glycoside from the Leaves of Eriobotrya japonica
• Anti-Androgen Active Constituents from Dalbergia cochinchinensis PIERRE
• Evaluation of the taste of crude drug and Kampo formula by a taste-sensing system (4) : taste of Processed Aconite Root
• Three new triterpenyl esters, codonopilates A-C, isolated from Codonopsis pilosula
• Seven Glycosides from Dioscorea bulbifera L.
• Seven Compounds from Dioscorea bulbifera L.(Natural Medicine Note)
• Structural Features of N-Glycans of Seaweed Glycoproteins : Predominant Occurrence of High-Mannose Type N-Glycans in Marine Plants
• A Specific Physical-Layer Network Coding for MPSK Modulation in Multi-Antenna Relay Networks

もっと見る 閉じる

スポンサーリンク