Cell Differentiation-Inducing Diterpenes from Andrographis paniculata NEES
スポンサーリンク
概要
- 論文の詳細を見る
The methanol extract of the aerial part of Andrographis paniculata NEES showed potent cell differentiation-inducing activity on mouse myeloid leukemia (M1) cells. From the ethyl acetate-soluble fraction of the methanol extract, six new diterpenoids of ent-labdane type, 14-epi-andrographolide (3), isoandrographolide (4), 14-deoxy-12-methoxyandrographolide (7), 12-epi-14-deoxy-12-methoxyandrographolide (8), 14-deoxy-12-hydroxyandrographolide (9) and 14-deoxy-11-hydroxyandrographolide (10) as well as two new diterpene glucosides, 14-deoxy-11,12-didehydroandrographi-side (12) and 6'-acetylneoandrographolide (14), and four new diterpene dimers, bis-andrograpolides A (15), B (16), C (17) and D (18), were isolated along with six known compounds. The structures of the diterpenoids were determined by means of spectral methods. Some of these compounds showed potent cell differentiation-inducing activity towards M1 cells.
- 社団法人日本薬学会の論文
- 1994-06-15
著者
-
黒柳 正典
静岡県大・薬
-
上野 明
School Of Pharmaceutical Sciences University Of Shizuoka
-
黒柳 正典
School of Bioresources, Hiroshima Prefectural University
-
松田 貴邦
School of Pharmaceutical Sciences, University of Shizuoka
-
杉山 聡子
School of Pharmaceutical Sciences, University of Shizuoka
-
梅原 薫
School of Pharmaceutical Sciences, University of Shizuoka
-
西 孝三郎
Tsukuba Medicinal Plant Research Station, National Institute of Hygienic Sciences
-
上野 明
School Of Pharmaceutical Science University Of Shizuoka
-
黒柳 正典
School Of Bioresources Hiroshima Prefectural University
-
杉山 聡子
School Of Pharmaceutical Sciences University Of Shizuoka
-
Umehara K
School Of Pharmaceutical Sciences University Of Shizuoka
-
梅原 薫
School Of Pharmaceutical Sciences University Of Shizuoka
-
松田 貴邦
School Of Pharmaceutical Sciences University Of Shizuoka
-
西 孝三郎
Tsukuba Medicinal Plant Research Station National Institute Of Hygienic Sciences
関連論文
- ヒヨス毛状根特異的発現遺伝子プロモーターのクローニングと解析 : 植物
- 60(P29) ブラジル産薬用植物、Carucaaのトリテルペンとその抗男性ホルモン作用(ポスター発表の部)
- ツルニンジン配合デザイナーフードの中高年男性における更年期障害様症状に対する改善作用
- 9 ヒヨス毛状根によるファイトアレキシンの生産に関する研究(口頭発表の部)
- 菖蒲根のセスキテルペン成分に関する研究
- 苦参 (Sophora flavescens AIT.) の成分に関する研究(第5報)
- 苦参(Sophora flavescens AIT.)の成分に関する研究(第4報)
- 苦参 (Sophora flavescens AIT.) の成分に関する研究(第3報)
- Studies on the Constituents of Sophora flavescens AITON. II
- Studies on Constituents from Chamaecyparis pisifera and Antibacterial Activity of Diterpenes
- チョロギに関する研究(第1報)新規配糖体の単離と構造
- Studies on the Glycosides of Epimedium grandiflorum MORR. var. thunbergianum (MIQ.) NAKAI. III
- 2 ガガイモ科及びナス科植物のステロイドとその細胞分化誘導活性(口頭発表の部)
- Cell Differentiation-Inducing Diterpenes from Andrographis paniculata NEES
- Studies on Differentiation-Inducers from Arctium Fructus
- Studies on the Differentiation Inducers of Myeloid Leukemic Cells from Citrus Species
- A.rhizogenesの感染によって誘導したヒヨス(Hyoscyamus niger)毛状根によるトロパンアルカロイドの生産〔英文〕
- Studies on Differentiation-Inducing Activities of Triterpenes
- 56 Andrographis paniculataの細胞分化誘導物質の研究(ポスター発表の部)
- Structures of Sesquiterpenes of Curcuma aromatica SALISB. II. : Studies on Minor Sesquiterpenes
- Studies on the Structures of Udosaponins A, B, C, D, E and F from Aralia cordata THUNB.
- Studies on the Saponins of Lonicera japonica THUNB.
- Iridoid Glucosides from Lonicera japonica THUNB.
- Flavonoids from Andrographis paniculata(Organic,Chemical)
- 70(PA2-10) Curcuma aromaticaのセスキテルペンとGermacrone 4,5-epoxideのトランスアンニュラー反応(ポスター発表の部)
- Structures of Sesquiterpenes from Curcuma aromatica SALISB(Organic,Chemical)
- Studies on Natural Antioxidants in Citrus Species. I. Determination of Antioxidative Activities of Citrus Fruits
- Diterpene-Glycosides of Stevia Paniculata LAG. : Structures of Aglycones
- Paniculosides-I-V, Diterpene-glucosides from Stevia ovata LAG.
- Diterpenoid Constituents of Rabdosia umbrosa (MAXIM.) : Isolation and Structure Elucidation of Two New Diterpenoids, Umbrosianin and Rabdoumbrosanin
- Inhibitors of Xanthine Oxidase from Athyrium mesosorum
- Scrophulasaponins II-IV, New Saikosaponin Homologs from Scrophularia kakudensis FRANCH.
- Clinoposaponins I-V, New Oleanane-Triterpene Saponins from Clinopodium gracile O. KUNTZE
- I-A-13 フジウツギから単離したサイコサポニン同族体の実験的肝障害抑制作用
- I-A-12 フジウツギから単離したサイコサポニン同族体の glucocorticoid 様作用
- BUDDLEJASAPONINS I - IV, FOUR NEW OLEANANE-TRITERPENE SAPONINS FROM THE AERIAL PARTS OF BUDDLEJA JAPONICA HEMSL.
- 常山の抗補体活性物質の研究。ステロイド誘導体の抗補体作用
- Inhibitors of Xanthine Oxidase from Alpinia galanga
- Inhibition of Xanthine Oxidase by Anthraquinones(Pharmacognosy,Chemical)
- Chemical Studies on Viburnum awabuki K.KOCH
- Sesquiterpene Lactones from Picris hieracioides L. var. japonica REGEL. I
- Studies on the Constituents of Baccharis genistelloides
- Sesquiterpene Lactones from Ixeris stolonifera A. GRAY
- Monoamine Oxidase Inhibitor from the Rhizomes of Kaempferia galanga L.
- Studies on the Acyl Glycosides from Leucoseptrum japonicum (MIQ.) KITAMURA et MURATA
- Studies on Differentiation Inducers. V. Steroid Glycosides from Periplocae Radicis Cortex
- Studies on the Constituents of Polygala japonica HOUTT. II. Structures of Polygalasaponins XI-XIX
- Studies on the Constituents of Polygala japonica HOUTT. I. Structures of Polygalasaponins I-X
- Studies on Differentiation Inducers. IV. Pregnane Derivatives from Condurango Cortex
- 544 トロパンアルカロイドの細胞外への透過生産に対するカルシウムの影響
- Monoamine Oxidase Inhibitors from Cinchonae Cortex
- Limonoids and Quinolone Alkaloids from Evodia rutaecarpa BENTHAM
- Revised Structures of Inflexin and Related Diterpenoids
- Senegoses J-O, Oligosaccharide Multi-Esters from the Roots of Polygala senega L.
- 莪〓の一新セスキテルペンCurzerenoneの構造について
- A Nuclear Magnetic Resonance Study of the Curzerenone
- 莪〓中の一新セスキテルペン, Zedoaroneの構造について
- Studies on the Constituents of Leaves of Citrus unshiu MARCOV.
- Antitumor-Promoting Constituents from Chaenomeles sinensis KOEHNE and Their Activities in JB6 Mouse Epidermal Cells
- Carbonic Anhydrase Inhibitors from the Pericarps of Punica granatum L.
- Tenuifolioses G-P, Oligosaccharide Multi-Esters from the Roots of Polygala tenuifolia WILLD.
- TENUIFOLIOSES A-F, OLIGOSACCHARIDE MULTI-ESTERS FROM THE ROOTS OF POLYGALA TENUIFOLIA WILLD.
- Differentiation Inducing Activities of Isocoumarins from Hydrangea Dulcis Folium
- Studies on Differentiation Inducers. VI.Lignan Derivatives from Arctium Fructus. (2)
- Kaurane-Type Diterpenes from Adenostemma lavenia O. KUNTZE
- Sesquiterpene Glycosides and Saponins from Cynara cardunculus L.
- Sesquiterpene Lactones from Cichorium endivia L. and C. intybus L. and Cytotoxic Activity
- Study of Enzyme Inhibitory Activities by Dipyridamole
- Studies on Benzochromones. IX. Syntheses of Hydroxyl Derivatives of 2-Methyl-5,6-benzochromone and 2-Methyl-3-acetyl-5,6-benzochromone
- Synthesis of 2-Methyl-5,8-dimethoxy-6,7-benzochromone
- 企業統合に成功するための7つの条件
- 化学企業の統合化と分化 (21世紀に向けて--「化学技術」新潮流に挑む)
- Studies on the Constituents of Solidago virga-aurea L. I. Structural Elucidation of Saponins in the Herb
- Iridoid Glycosides from Verbascum thapsus L.
- Novel Acylated Saponins from Tragopogon porrifolius L. Isolation and the Structures of Tragopogonsaponins A-R
- Five New Triterpene Saponins, Polygalasaponins XXVIII-XXXII from the Root of Polygala japonica HOUTT.
- Studies on the Constituents of Polygala japonica HOUTT. III. Structures of Polygalasaponins XX-XXVII
- STUDIES ON DIFFERENTIATION INDUCERS FROM PLANTS
- PC84 Isolation of Differentiation Inducers from Plant Sources
- Nine New Triterpene Saponins, Polygalasaponins XXXIII-XLI from the Roots of Polygala fallax HEMSL.
- Phytoestrogens from Aspalathus linearis(Pharmacognosy)
- Umbelliferone Released from Hairy Root Cultures of Pharbitis nil Treated with Copper Sulfate and Its Subsequent Glucosylation
- Effect of γ-Oryzanol on Cytochrome P450 Activities in Human Liver Microsomes(Biopharmacy)
- Effect of Probucol on Cytochrome P450 Activities in Human Liver Microsomes
- Prolyl Endopeptidase Inhibitors from the Roots of Lindera strychnifolia F. VILL
- Inhibition of Human Drug Metabolizing Cytochrome P450 by Buprenorphine
- Six New Presenegenin Glycosides, Reiniosides A-F, from Polygala reinii Root
- Reinioses A-J, Oligosaccharide Multi-Esters from the Roots of Polygala reinii FR. et SAV.
- Stachyssaponins I-VIII, New Oleanane-Type Triterpene Saponins from Stachys riederi CHAMISSO
- Studies on the Constituents of Solidago virga-aurea L. III. Structures of Solidagosaponins XXI-XXIX
- Senegoses F-I, Oligosaccharide Multi-Esters from the Roots of Polygala senega var. latifolia TORR. et GRAY
- Senegoses A-E, Oligosaccharide Multi-Esters from Polygala senega var. latifolia TORR. et GRAY
- Sesquiterpene Glycosides from Ainsliaea cordifolia FRANCH. et SAV.
- NEW 5β-H LIMONOIDS FROM ___ ___ BENTHAM
- Studies on Benzochromones. VIII. Ring Isomerization of γ-Pyrone Ring condensed with Naphthoquinone
- A. rhizogenes の感染によって誘導したヒヨス (Hyoscyamus niger) 毛状根によるトロパンアルカロイドの生産
- Studies on the Constituents of Solidago virga-aurea L. II. Structures of Solidagosaponins X-XX
- Studies on the Pterocarpans from Melilotus alba DESR.
- Chemical Studies on the Constituents of Polygonum nodosum
- Acylated Iridoid Glycosides from Buddleja japonica HEMSL.