Effect of γ-Oryzanol on Cytochrome P450 Activities in Human Liver Microsomes(Biopharmacy)
スポンサーリンク
概要
- 論文の詳細を見る
The effects of γ-oryzanol, a drug mainly used for the treatment of hyperlipidaemia, on several cytochrome P450 (CYP) specific reactions in human liver microsomes were investigated to predict drug interactions with γ-oryzanol in vivo from in vitro data. The following eight CYP catalytic reactions were used in this study: CYPlA1/2-mediated 7-ethoxyresorufin O-deethylation, CYP2A6-mediated coumarin 7-hydroxylation, CYP2B6-mediated 7-benzyloxyresorufin O-debenzylation, CYP2C8/9-mediated tolbutamide methylhydroxylation, CYP2C19-mediated S-mephenytoin 4'-hydroxylation, CYP2D6-mediated bufuralol 1'-hydroxylation, CYP2E1-mediated chlorzoxazone 6-hydroxylation, and CYP3A4-mediated testosterone 6β-hydroxylation. γ-Oryzanol had little inhibitory effects on CYP activities, indicating that this compound would not be expected to cause clinically significant interactions with other CYP-metabolized drugs at expected therapeutic concentrations.
- 公益社団法人日本薬学会の論文
- 2004-07-01
著者
-
梅原 薫
School of Pharmaceutical Sciences, University of Shizuoka
-
SHIMOKAWA Yoshihiko
Tokushima Research Institute, Otsuka Pharmaceutical Co. Ltd.
-
MIYAMOTO Gohachiro
Tokushima Research Institute, Otsuka Pharmaceutical Co. Ltd.
-
Umehara K
School Of Pharmaceutical Sciences University Of Shizuoka
-
梅原 薫
School Of Pharmaceutical Sciences University Of Shizuoka
-
UMEHARA Ken
Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.
-
Shimokawa Y
Tokushima Research Institute Otsuka Pharmaceutical Co. Ltd.
-
Shimokawa Yoshihiko
Tokushima Research Institute Otsuka Pharmaceutical Co. Ltd.
-
Miyamoto G
Tokushima Research Institute Otsuka Pharmaceutical Co. Ltd.
-
Miyamoto Gohachiro
Tokushima Research Institute Otsuka Pharmaceutical Co. Ltd.
関連論文
- Studies on Constituents from Chamaecyparis pisifera and Antibacterial Activity of Diterpenes
- 2 ガガイモ科及びナス科植物のステロイドとその細胞分化誘導活性(口頭発表の部)
- Cell Differentiation-Inducing Diterpenes from Andrographis paniculata NEES
- Studies on Differentiation-Inducers from Arctium Fructus
- Studies on the Differentiation Inducers of Myeloid Leukemic Cells from Citrus Species
- Studies on Differentiation-Inducing Activities of Triterpenes
- Studies on the Saponins of Lonicera japonica THUNB.
- Inhibition of Xanthine Oxidase by Anthraquinones(Pharmacognosy,Chemical)
- Studies on Differentiation Inducers. V. Steroid Glycosides from Periplocae Radicis Cortex
- Studies on the Constituents of Polygala japonica HOUTT. II. Structures of Polygalasaponins XI-XIX
- Studies on the Constituents of Polygala japonica HOUTT. I. Structures of Polygalasaponins I-X
- Studies on Differentiation Inducers. IV. Pregnane Derivatives from Condurango Cortex
- Monoamine Oxidase Inhibitors from Cinchonae Cortex
- Studies on the Constituents of Leaves of Citrus unshiu MARCOV.
- Antitumor-Promoting Constituents from Chaenomeles sinensis KOEHNE and Their Activities in JB6 Mouse Epidermal Cells
- High performance liquid chromatographic methods for the determination of aripiprazole with ultraviolet detection in rat plasma and brain : Application to the pharmacokinetic study
- Differentiation Inducing Activities of Isocoumarins from Hydrangea Dulcis Folium
- Studies on Differentiation Inducers. VI.Lignan Derivatives from Arctium Fructus. (2)
- Kaurane-Type Diterpenes from Adenostemma lavenia O. KUNTZE
- Sesquiterpene Glycosides and Saponins from Cynara cardunculus L.
- Sesquiterpene Lactones from Cichorium endivia L. and C. intybus L. and Cytotoxic Activity
- Five New Triterpene Saponins, Polygalasaponins XXVIII-XXXII from the Root of Polygala japonica HOUTT.
- Studies on the Constituents of Polygala japonica HOUTT. III. Structures of Polygalasaponins XX-XXVII
- STUDIES ON DIFFERENTIATION INDUCERS FROM PLANTS
- PC84 Isolation of Differentiation Inducers from Plant Sources
- Nine New Triterpene Saponins, Polygalasaponins XXXIII-XLI from the Roots of Polygala fallax HEMSL.
- Phytoestrogens from Aspalathus linearis(Pharmacognosy)
- Umbelliferone Released from Hairy Root Cultures of Pharbitis nil Treated with Copper Sulfate and Its Subsequent Glucosylation
- Effect of γ-Oryzanol on Cytochrome P450 Activities in Human Liver Microsomes(Biopharmacy)
- Effect of Probucol on Cytochrome P450 Activities in Human Liver Microsomes
- Prolyl Endopeptidase Inhibitors from the Roots of Lindera strychnifolia F. VILL
- Inhibition of Human Drug Metabolizing Cytochrome P450 by Buprenorphine
- Constituents from the Roots of Taraxacum platycarpum and Their Effect on Proliferation of Human Skin Fibroblasts
- Constituents from the Roots of Taraxacum platycarpum and Their Effect on Proliferation of Human Skin Fibroblasts