Studies on Differentiation Inducers. VI.Lignan Derivatives from Arctium Fructus. (2)
スポンサーリンク
概要
- 論文の詳細を見る
In the previous paper, we reported the differentiation inducing activities of lignoids from Arctium Fructus (the fruits of Arctium lappa L., Compositae) against mouse myeloid leukemia cells (M1). We reinvestigated the active components of this extract and isolated three new dilignans. Furthermore, structure modifications were carried out using the most active lignan (arctigenin, 1) and its structure-activity relationship was investigated. Its aliphatic esters were more effective in inducing the differentiation of M1 cels than its aromatic esters. Especially, n-decanoate, which was the most active derivative, induced more than half of the M1 cells into phagocytic cells at a concentration of 2 μM.
- 公益社団法人日本薬学会の論文
- 1996-12-15
著者
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UMEHARA Kaoru
School of Pharmaceutical Sciences, University of Shizuoka
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KUROYANAGI Masanori
School of Bioresources, Hiroshioma Prefectural University
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Nakamura M
Seiwa Pharmaceutical Ltd.
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Kuroyanagi M
Fac. Of Pharmaceutical Sciences At Kagawa Campus Tokushima Bunri Univ.
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Miyase T
School Of Pharmaceutical Sciences University Of Shizuoka
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Miyase Toshio
School Of Pharmaceutical Science University Of Shizuoka
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梅原 薫
School of Pharmaceutical Sciences, University of Shizuoka
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UENO Akira
Second Department of Surgery, Yamanashi Medical College
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Ueno A
Yamanashi Medical Coll. Yamanashi Jpn
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Ueno Akira
School Of Pharmaceutical Sciences University Of Shizuoka
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NAKAMURA Mitsuhiro
School of Pharmaceutical Sciences, University of Shizuoka
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MIYAKE Toshio
School of Pharmaceutical Sciences, University of Shizuoka
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Umehara K
School Of Pharmaceutical Sciences University Of Shizuoka
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梅原 薫
School Of Pharmaceutical Sciences University Of Shizuoka
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Umehara Kaoru
School Of Pharmaceutical Sciences University Of Shizuoka
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Kuroyanagi M
Department Of Life Sciences Faculty Of Life And Environmental Science Prefectural University Of Hiro
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Kuroyanagi Masanori
School Of Bioresources Hiroshima Prefectural University
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Ueno Akira
School of Pharmaceutical Sciences, University of Shizuoka
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