Acyl-CoA : Cholesterol Acyltransferase(ACAT) Inhibitors from Ilex spp.
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概要
- 論文の詳細を見る
Activity-guided fractionation of a methanol extract of the leaves ofIlex kudincha, I. latifolia and I. cornuta led to the isolation of twenty-six acyl-CoA:cholesterol acyltransferase (ACAT) inhibitory triterpenes. Nineteen of them were identified by spectroscopic methods as uvaol (1), ursolic aldehyde (2), ursolic acid (3), ursolic acid acetate (4), 23-hydroxyursolic acid (5), 2α-hydroxyuvaol (6), 11-oxoursolic acid (8), ilekudinol B methyl ester (10), 11,12-dehydroursolic acid lactone (11), ilekudinol A (13), ulmoidol (14), 27-trans-pcoumaroyloxyursolic acid (15), 3β-hydroxyolean-12-en-11-one (17), erythrodiol (18), oleanolic aldehyde (19), lupeol (21), betulin (22), ilekudinol C (23) and 30-oxolupeol (26), and seven were new compounds named ilelatifol A (7),ilecornol A methyl ester (9), ilelatifol D (12), ilelatifol C (16), ilelatifol B (20), ilekudinol D methyl ester (24) and ilekudinol E methyl ester (25). Compounds 4-7, 9-20 and 22-25 showed inhibitory activity in the ACAT assay.
- 日本生薬学会の論文
- 2000-12-20
著者
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Miyase Toshio
School Of Pharmaceutical Science University Of Shizuoka
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Chen Xin-min
Division Of Phytochemistry Chengdu Institute Of Biology Academia Sinica
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Chen Xin-min
Divison Of Phytochemistry Chengdu Institute Of Biology Academia Sinica
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Noguchi Hiroshi
School Of Pharmaceutical Sciences And The Coe 21 Program University Of Shizuoka
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Noguchi Hiroshi
School Of Pharmaceutical Sciences University Of Shizuoka
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Nishimura Keiichi
R&D Institute of Health Science, POLA Corporation
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Nishimura Keiichi
R&d Institute Of Health Science Pola Corporation
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