A Convenient Synthesis of 1, 1-Disubstituted 1, 2, 3, 4-Tetrahydroisoquinolines via Pictet-Spengler Reaction Using Titanium(IV)Isopropoxide and Acetic-Formic Anhydride
スポンサーリンク
概要
- 論文の詳細を見る
A synthesis of 1, 1-disubstituted 1, 2, 3, 4-tetrahydroisoquinolines(6)was achieved in a highly efficient manner via Pictet-Spengler reaction of arylethylamines(1)and acyclic and cyclic ketones(2)using titanium(IV)isopropoxide and acetic-formic anhydride. The cyclization of the in situ formed acyliminium ion(4)to N-formyl 1, 2, 3, 4-tetrahydroisoquinoline(5)was greatly facilitated by using trifluoroacetic acid as an additional reagent. The Picket-Spengler reaction was carried out by one pot procedure, providing a convenient and effective method for preparing various 1, 2, 3, 4-tetrahydroisoquinolines.
- 公益社団法人日本薬学会の論文
- 2002-02-01
著者
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吉村 昭毅
北海道医療大学薬学部
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Nakamura M
Seiwa Pharmaceutical Ltd.
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佐野 武弘
昭和薬科大学
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佐野 武弘
Showa Pharmaceutical Univ. Tokyo Jpn
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SANO Takehiro
Showa College of Pharmaceutical Sciences
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SAITOH Toshiaki
Showa College of Pharmaceutical Sciences
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HORIGUCHI Yoshie
Showa College of Pharmaceutical Sciences
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Nakamura Masayoshi
Showa Pharmaceutical University
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KODAMA Hirokazu
Showa Pharmaceutical University
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YOSHIMURA Tsuyoshi
Showa Pharmaceutical University
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HANEZI Kaori
Showa Pharmaceutical University
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HAMADA Hiroko
Showa Pharmaceutical University
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Hamada H
Showa Pharmaceutical University
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Kodama H
Showa Pharmaceutical University
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Yoshimura T
Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaido
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Horiguchi Y
Showa Pharmaceutical University
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