Pharmacological Study on the Novel Antinociceptive Agent, a Novel Monoterpene Alkaloid from Incarvillea sinensis(Pharmacognosy)
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概要
- 論文の詳細を見る
To determine the antinociceptive mechanism of incarvillateine (INCA), the opiate antagonists nor-binaltor-phimine (nor-BNI), β-funaltrexamine (β-FNA) and naltrindole (NTI) were pretreated prior to its injection in a formalin test. The antinociceptive effect of INCA was antagonized by nor-BNI (K-receptor antagonist) and β-FNA (μ-receptor antagonist), while NTI (δ-receptor antagonist) did not influence its effect. Furthermore, the antinociceptive effect of INCA was blocked by theophylline (THEO), an adenosine-receptor antagonist. These results suggested that the antinociceptive effect arose from the activation of μ-, K-receptors and adenosine-receptor.
- 2005-10-01
著者
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Nohara Toshihiro
Faculty of Pharmaceutical Sciences, Sojo University
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SAKURADA Shinobu
Department of Pharmacology, Tohoku College of Pharmacy
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Sakurada Shinobu
Department Of Pharmacology Tohoku Pharmaceutical University
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Sakurada Shinobu
中華人民共和国
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KINJO Junei
Faculty of Pharmaceutical Sciences, Fukuoka University
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Nohara T
Fac. Of Pharmaceutical Sciences Sojo Univ.
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Kinjo Junei
Faculty Of Pharmaceutical Sciences Fukuoka University
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Kinjo Junei
Department Of Pharmacognosy Faculty Of Pharmaceutical Sciences Fukuoka University
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Kinjo Junei
福岡大学 薬学部
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Kinjo Junei
熊本大学 薬
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Nohara T
Faculty Of Pharmaceutical Sciences Kumamoto University
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CHI Yu-Ming
Seiwa Pharmaceutical Ltd.
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NAKAMURA Motoyuki
Seiwa Pharmaceutical Ltd.
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YOSHIZAWA Toyokichi
Seiwa Pharmaceutical Ltd.
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YAN Wen-Mei
Beijing University of Traditional Chinese Medicine and Pharmacy
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HASHIMOTO Fumio
Faculty of Pharmaceutical Sciences, Kumamoto University
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CHI Yu
Seiwa Pharmaceutical, Ltd.
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ZHAO Xi
Seiwa Pharmaceutical, Ltd.
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YAN Wen
Beijing University of Traditional Chinese Medicine and Pharmacy
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Zhao Xi
Seiwa Pharmaceutical Ltd.
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Yoshizawa Toyokichi
Seiwa Pharmaceutical Co. Ltd.
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Chi Yu
Seiwa Pharmaceutical Ltd.
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Hashimoto Fumio
Faculty Of Pharmaceutical Sciences Kumamoto University
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Hashimoto F
Faculty Of Agriculture Kagoshima University
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Hashimoto F
Kagoshima Univ. Kagoshima
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金城 順英
熊本大学 薬
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Nakamura M
Seiwa Pharmaceutical Ltd.
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Jung K
Laboratory Of Immunomodulator Korea Research Institute Of Bioscience And Biotechnology
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Nohara Toshihiro
Fac. Of Pharmaceutical Sciences Sojo Univ.
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Kinjo J
Faculty Of Pharmaceutical Sciences Fukuoka University
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Kim J-h
Faculty Of Pharmaceutical Sciences Fukuoka University
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Jung K
Korea Res. Inst. Biosci. And Biotechnol. Taejon Kor
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Hashimoto Fumio
Department Of Orthodontics Graduate School Of Biomedical Sciences Nagasaki University
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Hashimoto Fumio
Laboratory Of Ornamental Horticulture Kagoshima University
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Nohara Toshihiro
Faculty Of Medical And Pharmaceutical Science Kumamoto University
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Nakamura Takanori
Faculty Of Pharmaceutical Sciences Kumamoto University
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Nakamura Takanori
Hitachi Zosen Co.
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Nohara T
Faculty Of Medical And Pharmaceutical Sciences Kumamoto University
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Kinjyo Junei
Faculty Of Pharmaceutical Sciences Kumamoto University
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Hashimoto Fumio
Faculity Of Science Osaka City University
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Nakamura Takanori
Faculty of Medical and Pharmaceutical Sciences, Kumamoto University
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SAKURADA Shinobu
Department of Chemical Pharmacology Tohoku College of Pharmacy
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Nohara Toshihiro
Faculty of Medical and Pharmaceutical Scieces, Sojo University
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