HPLC Profile Analysis of Hepatoprotective Oleanene-Glucuronides in Puerariae Flos
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概要
- 論文の詳細を見る
In order to confirm the constitution of hepatoprotective oleanene glucuronide (OG), HPLC profile analyses of the total OG fractions of both Puerariae Thomsonii Flos (the flowers of Pueraria thomsonii) and Puerariae Lobatae Flos (the flowers of P. lobata) were performed. No remarkable difference in the HPLC profiles with respect to OGs in the flowers was shown, in contrast to those of the roots. By repeated chromatography of the total OG fraction of Puerariae Thomsonii Flos, soyasaponin I (1), kaikasaponin III (2) and kakkasaponin I (3), which had been already isolated from Puerariae Lobatae Flos, were obtained. The hepatoprotective activity of 2 towards immunologically induced liver injury was significantly more effective than that of 1. This information supported previously obtained structure-hepatoprotective relationship data which was measured on another model. The structure-activity relationship information which suggested that the hydroxymethyl group of the galactosyl unit would enhance the hepatoprotective activity was also substantiated.
- 社団法人日本薬学会の論文
- 1999-05-15
著者
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Okawa Masafumi
Faculty of Pharmaceutical Sciences, Fukuoka University
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Nohara Toshihiro
Faculty of Pharmaceutical Sciences, Sojo University
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Nakajima Yukiko
Department Of Pharmacy The University Of Tokyo Hospital Faculty Of Medicine The University Of Tokyo
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Aoki Katsuya
Faculty Of Pharmaceutical Sciences Kumamoto University
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NAKAJIMA Yoshijiro
Tsukuba Research Institute, Ohta's Isan Co. Ltd.
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YAMAZAKI Takashi
Tsukuba Research Institute, Ohta's Isan Co. Ltd.
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NIIHO Yujiro
Tsukuba Research Institute, Ohta's Isan Co. Ltd.
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KINJO Junei
Faculty of Pharmaceutical Sciences, Fukuoka University
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SHII Yuichi
Faculty of Pharmaceutical Sciences, Kumamoto University
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HIRAKAWA Tomoki
Faculty of Pharmaceutical Sciences, Kumamoto University
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HOSONO Tsuyoshi
Tsukuba Research Institute, Ohta's Isan Co., Ltd.,
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SOMEYA Masako
Tsukuba Research Institute, Ohta's Isan Co., Ltd.,
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KURASHIGE Tatsuo
Tsukuba Research Institute, Ohta's Isan Co., Ltd.,
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Yamasaki Toru
東海大学 農学部
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Kurashige Tatsuo
Tsukuba Research Institute Ohta's Isan Co. Ltd.
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Kinjo Junei
Faculty Of Pharmaceutical Sciences Fukuoka University
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Kinjo Junei
熊本大学 薬
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Someya Masako
Tsukuba Research Institute Ohta's Isan Co. Ltd.
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Niiho Yujiro
福岡大学 薬学部
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Niiho Yujiro
Tsukuba Research Institute Ohta's Isan Co. Ltd
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Nakajima Yoshijiro
福岡大学 薬学部
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Hosono Tsuyoshi
Tsukuba Research Institute Ohta's Isan Co. Ltd.
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Hirakawa Tomoki
Faculty Of Pharmaceutical Sciences Kumamoto University
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Hirakawa Tomoki
福岡大学 薬
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Shiono Yuki
School Of Agriculture Tokai Univ.
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Nakajima Y
Ohta's Isan Co. Ltd. Ibaraki Jpn
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Kim J-h
Faculty Of Pharmaceutical Sciences Fukuoka University
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Nohara Toshihiro
Faculty Of Medical And Pharmaceutical Science Kumamoto University
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Yamazaki Takashi
Department Of Life Science Graduate School Of Bioscience And Biotechnology Tokyo Institute Of Techno
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Hirose Toshiharu
Faculty Of Pharmaceutical Sciences Kanazawa University
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中島 良徳
北海道薬科大学微生物学研究室
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Yahara Shoji
Graduate School Of Pharmaceutical Sciences Kumamoto University
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Kinjyo Junei
Faculty Of Pharmaceutical Sciences Kumamoto University
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YAMAZAKI Takashi
College of Science and Technology, Nihon University
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Okawa Masafumi
Faculty Of Pharmaceutical Sciences Fukuoka University
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Hirakawa Tomoki
Faculty Of Pharmaceutical Sciences Kanazawa University
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Yahara Shoji
Graduate School Of Pharmaceutical Sciences Kumamoto Univ.
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Nakajima Y
Tsukuba Research Institute Ohta's Isan Co. Ltd.
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Yamazaki T
Tsukuba Research Institute Ohta's Isan Co. Ltd.
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Yasuda Shin
Tokai Univ. School Of Agriculture
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Niiho Yujiro
Tsukuba Research Institute
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Yamazaki Takashi
Tsukuba Research Institute, Ohta's Isan Co. Ltd.
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Nohara Toshihiro
Faculty of Medical and Pharmaceutical Scieces, Sojo University
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