Trypanocidal Constituents in Plants 6. Minor Withanolides from the Aerial Parts of Physalis angulata

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概要

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• Further study of the methanol extract of the aerial parts of Physalis angulata (Solanaceae) resulted in the isolation of new withanolides, designated physagulins L, M and N, together with known withanolide, physagulin D and flavonol glycoside, quercetin 3-O-rhamnosyl-(1→6)-galactoside. The chemical structures of these new withanolides were elucidated by detailed spectroscopic analyses to be (20R,22R)-15α-acetoxy-5α,6β,14β,17β,27-pentahydroxy-1-oxo-witha-2, 24-dienolide, (20S,22S)-15α-acetoxy-5α,6β,14α,23β-tetrahydroxy-1-oxo-witha-2,16,24-trienolide and (20S,22R)-15α-acetoxy-5β,6β-epoxy-14α-hydoxy-3β-methoxy-1-oxo-witha-16,24-dienolide, respectively. All these compounds showed weak trypanocidal activity against trypomastigotes, an infectious form of Trypanosoma cruzi, the etiologic agent for Chagas' disease. Withanolides obtained in the previous paper showed considerable trypanocidal activity, suggesting the structure-activity relationships.

• 社団法人日本薬学会の論文
• 2006-08-01

著者

• Okawa Masafumi

  Faculty of Pharmaceutical Sciences, Fukuoka University

• 阿部 フミ子

  Faculty Of Pharmaceutical Sciences Fukuoka University

• KINJO Junei

  Faculty of Pharmaceutical Sciences, Fukuoka University

• Kinjo Junei

  Faculty Of Pharmaceutical Sciences Fukuoka University

• Kinjo Junei

  Department Of Pharmacognosy Faculty Of Pharmaceutical Sciences Fukuoka University

• Kinjo Junei

  福岡大学 薬学部

• Kinjo Junei

  Faculty Of Pharmaceutical Sciences Kumamoto University

• Kinjo Junei

  熊本大学 薬

• Okawa Masafumi

  東海大学 農学部

• ABE Fumiko

  Faculty of Pharmaceutical Sciences, Fukuoka University

• NAGAFUJI Shinya

  Faculty of Pharmaceutical Sciences, Fukuoka University

• Jung K

  Laboratory Of Immunomodulator Korea Research Institute Of Bioscience And Biotechnology

• Abe Fumiko

  Faculty Of Pharmaceutical Science Fukuoka University

• Kinjo J

  Faculty Of Pharmaceutical Sciences Fukuoka University

• Kim J-h

  Faculty Of Pharmaceutical Sciences Fukuoka University

• Nagafuji Shinya

  Faculty Of Pharmaceutical Sciences Fukuoka University

• Okawa Masafumi

  Faculty Of Pharmaceutical Sciences Fukuoka University

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