Ursolic Acid as a Trypanocidal Constituent in Rosemary

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概要

• 論文の詳細を見る

• The MeOH extract of the leaves of rosemary (Rosmarinus officinalis L.) completely inhibited the motility of cultured epimastigotes of Trypanosoma cruzi at the concentration of 2 mg/ml after 2 h of incubation. Activityguided fractionation of the MeOH extract has resulted in the isolation of three triterpene acids, betulinic, oleanolic and ursolic acids. Ursolic acid stopped the movement of all T cruzi epimastigotes at the minimum concentration (MC_100) of 40μg/ml (88μ_M) after 48 h of incubation. Oleanolic acid was less active (MC_100: 250μg/ml, 550μ_M) and betulinic acid was practically inactive.

• 公益社団法人日本薬学会の論文
• 2002-11-01

著者

• Nagao Toshiyuki

  Department Of Pharmacology Faculty Of Pharmacy Meijo University

• 岡部 光

  Faculty Of Pharmaceutical Sciences Fukuoka University

• 阿部 フミ子

  Faculty Of Pharmaceutical Sciences Fukuoka University

• 赤羽 啓栄

  福岡医大

• Yamazaki Tadashi

  東京大学 医学系研究科循環器内科

• 赤羽 啓栄

  School Of Medicine Fukuoka University

• 赤羽 啓栄

  九州大学 寄生虫

• 赤羽 啓栄

  信州大・志賀高原生研

• 赤羽 啓栄

  福岡大学 病理学

• KINJO Junei

  Faculty of Pharmaceutical Sciences, Fukuoka University

• Kinjo Junei

  Faculty Of Pharmaceutical Sciences Fukuoka University

• Kinjo Junei

  Department Of Pharmacognosy Faculty Of Pharmaceutical Sciences Fukuoka University

• Kinjo Junei

  福岡大学 薬学部

• Kinjo Junei

  熊本大学 薬

• ABE Fumiko

  Faculty of Pharmaceutical Sciences, Fukuoka University

• OKABE Hikaru

  Faculty of Pharmaceutical Sciences, Fukuoka University

• AKAHANE Hiroshige

  School of Medicine, Fukuoka University

• NAGAO Tsuneatsu

  Faculty of Pharmaceutical Sciences, Fukuoka University

• Okabe Hikaru

  Faculty Of Pharmaceutical Sciences Fukuoka University

• 岡部 光

  福岡大学

• Okabe Hikaru

  福岡大学 薬学部

• 岡部 光

  福岡大学薬学部

• 金城 順英

  熊本大学 薬

• Akahane H

  School Of Medicine Fukuoka University

• 赤羽 啓栄

  福岡大医

• Abe Fumiko

  Faculty Of Pharmaceutical Science Fukuoka University

• Kinjo J

  Faculty Of Pharmaceutical Sciences Fukuoka University

• Kim J-h

  Faculty Of Pharmaceutical Sciences Fukuoka University

• YAMAUCHI Tatsuo

  Faculty of Pharmaceutical Sciences, Fukuoka University

• HIGO Hiroo

  Graduate School of Medical Sciences, Kyushu University

• Akahane Hiroshige

  福岡大学医学部寄生虫学

• Nagao T

  Faculty Of Pharmaceutical Sciences Fukuoka University

• Higo H

  Graduate School Of Medical Sciences Kyushu University

• Yamauchi T

  Faculty Of Medicinal Chemistry; Hoshi University

• 赤羽 啓栄

  福岡大学 医学部 寄生虫学 教室

• Yamauchi Tatsuo

  Faculty Of Pharmaceutical Sciences Fukuoka University

• Nagao Tsuneatsu

  Faculty Of Pharmaceutical Sciences Fukuoka University

• Yamauchi T

  Dep. Of Biochemistry Inst. Of Health Biosciences And Graduate School Of Pharmaceutical Sciences The

• Yamauchi Takako

  Hayashibara Biochemical Laboratories Inc.

• YAMAUCHI Tatsuo

  Faculty of Agriculture, Kyoto University

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