Antiproliferative Constituents from Umbelliferae Plants VI. New Ursane-Type Saikosaponin Analogs from the Fruits of Bupleunim rotundifolium
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概要
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The MeOH extract of the fruits of Bupleurum rotundifolium showed inhibitory activity against human gastric adenocarcinoma (MK-1) cell gnmth (GI_50 : 6.25 μg/ml). From this extract, 10 new ursane-type triterpene glycosides viz. three 3-O-triosides (called rotundifoliosides A, I, and J) of 13β,28-epoxy-3β,16α,21β-trihydroxyurs-11-ene, two (G and H) of 13β,28-epoxy-3β,16α,23-trihydroxyurs-11-ene, two (E and F) of 13β,28-epoxy-3β,16α,21β-trihydroxyurs-11-ene, two (B and C) of 3β,11α,16α,28-tetrahydroxyurs-12-ene, and one (D) of 3β,11α,28-trihydroxy-15α,16α-epoxyurs-12-ene were isolated in addition to 16 new oleanane-type triterpene glycosides (rotundiosides J-Y), echinocystic acid 3-O-suIfate and 3 known oleanane-type triterpene glycosides (rotundiosides A, F and G). The isolation, structures and antiproliferative activity of the new ursane-type triterpene glycosides against MK-1, human uterus carcinoma (HeLa), and murine melanoma (B16F10) cell lines are described with some comments on the structural requirements for their activity.
- 公益社団法人日本薬学会の論文
- 2003-04-01
著者
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Nagamatsu T
Department Of Pharmacobiology And Therapeutics Faculty Of Pharmacy Meijo University
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Nagao Toshiyuki
Department Of Pharmacology Faculty Of Pharmacy Meijo University
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Nagamatsu T
Department Of Pharmacology Faculty Of Pharmacy Meijo University
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岡部 光
Faculty Of Pharmaceutical Sciences Fukuoka University
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Matsunaga Keiji
Graduate School Of Pharmaceutical Sciences Kyoto University
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OKABE Hikaru
Faculty of Pharmaceutical Sciences, Fukuoka University
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NAGAO Tsuneatsu
Faculty of Pharmaceutical Sciences, Fukuoka University
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FUJIOKA Toshihiro
Faculty of Pharmaceutical Sciences, Fukuoka University
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Okabe Hikaru
Faculty Of Pharmaceutical Sciences Fukuoka University
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岡部 光
福岡大学
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Okabe Hikaru
福岡大学 薬学部
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岡部 光
福岡大学薬学部
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Fujii Hiroko
Faculty Of Pharmaceutical Sciences Fukitoka University
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MIHASHI Kunihide
Faculty of Pharmaceutical Sciences, Fukuoka University
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FUJII Hisashi
Kanagawa Industrial Technology Research Institute
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Matsunaga Kazuhisa
Faculty Of Pharmaceutical Sciences Fukuoka University
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Nagao T
Faculty Of Pharmaceutical Sciences Fukuoka University
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YOSHIDA Keisuke
Faculty of Pharmaceutical Sciences, Fukuoka University
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Matsunaga K
Faculty Of Pharmaceutical Sciences Fukuoka University
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Fujii H
Kanagawa Industrial Technology Research Institute
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Fujioka T
Faculty Of Pharmaceutical Sciences Fukuoka University
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Fujioka Toshihiro
Faculty Of Pharmaceutical Sciences Fukuoka University
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Nagao Tsuneatsu
Faculty Of Pharmaceutical Sciences Fukuoka University
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Yoshida Keisuke
Faculty Of Mechanical Engineering Kyushu University
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Mihashi Kunihide
Faculty Of Pharmaceutical Sciences Fukuoka University
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