Involvement of Prostaglandin E_2 in Clearance of Aggregated Protein via Protein Kinase A in Glomeruli
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概要
- 論文の詳細を見る
Recently we immunohistochemically demonstrated that prostaglandin E2 (PGE2) promoted the clearance of aggregated bovine serum albumin (a-BSA) deposited in glomeruli. Herein, we investigated the role of PGE2 and its signal transduction in the disposal of macromolecules in glomeruli. EP2 and EP4 receptor mRNA was detected in glomeruli by RT-PCR analysis. A-BSA was injected twice into mice. Glomeruli were then isolated and incubated. A-BSA gradually disappeared from isolated glomeruli. PGE2 increased the intracellular cyclic AMP and decreased a-BSA level in glomeruli. Additionally, 8-bromo-cyclic AMP evoked a loss of a-BSA in isolated glomeruli. The effect of 8-bromo-cyclic AMP on the clearance of a-BSA was abolished by KT 5720 in glomeruli. PGE2 and 8-bromo-cyclic AMP also prompted disposal of a-BSA in cultured mesangial cells. These findings indicate that PGE2 positively regulates the removal of macromolecules via cyclic AMP and protein kinase A in glomeruli, and they provide insight into how to prevent the development of glomerulonephritis and glomerulosclerosis.
- 社団法人 日本薬理学会の論文
- 2001-02-01
著者
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Nagamatsu T
Department Of Pharmacobiology And Therapeutics Faculty Of Pharmacy Meijo University
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Nagamatsu Tadashi
名城大学 薬学部薬理学
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Nagamatsu Tadashi
Department Of Pharmacobiology And Therapeutics Faculty Of Pharmacy Meijo University
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Nagao T
Laboratory Of Pharmacobiology And Theraperutics Faculty Of Pharmaceutical Science Meijo University
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Nagao Toshiyuki
Department Of Pharmacology Faculty Of Pharmacy Meijo University
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Nagamatsu T
Department Of Pharmacology Faculty Of Pharmacy Meijo University
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Suzuki Y
School Of Pharmaceutical Sciences University Of Shizuoka
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Suzuki Y
Fukuoka Inst. Technol. Fukuoka
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SUZUKI Yoshio
Department of Pharmacology, Faculty of Pharmacy, Meijo University
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KOSEKI Jun-ichi
Department of Pharmacology, Faculty of Pharmacy, Meijo University
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SUGIURA Masayuki
Toxicology Laboratory, Taisho Pharmaceutical Co., Ltd.
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NISHIYAMA Tsutomu
Toxicology Laboratory, Taisho Pharmaceutical Co., Ltd.
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Suzuki Y
Department Of Pharmacobiology And Therapeutics Faculty Of Pharmacy Meijo University
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Suzuki Y
Core Research For Evolutional Science And Technology (crest Jst) University Of Shizuoka School Of Ph
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Nishiyama T
Laboratory Animal Center Taisho Pharmaceutical Co. Ltd.
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Sugiura Masayuki
Toxicology Laboratory Medicinal Research Laboratories Taisho Pharmaceutical Co. Ltd.
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Sugiura Masayuki
Toxicology Laboratory Taisho Pharmaceutical Co. Ltd.
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Koseki Jun-ichi
Department Of Pharmacology Faculty Of Pharmacy Meijo University
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Suzuki Y
Department Of Pharmacology Faculty Of Pharmacy Meijo University
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Suzuki Yoshio
Department Of Chemical Science & Technology Faculty Of Engineering Kyushu University
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Koseki Junichi
Department of Pharmacology, Faculty of Pharmacy, Meijo University
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