Acteoside, a Component of <I>Stachys Sieboldii</I> MIQ, May Be a Promising Antinephritic Agent: Effect of Acteoside on Crescentic-Type Anti-GBM Nephritis in Rats
スポンサーリンク
概要
- 論文の詳細を見る
Effects of acteoside (ACT) on crescentic-type anti-GBM nephritis in rats were investigated. When rats were treated with ACT from the 1st day after i.v. injection of anti-GBM serum, ACT inhibited the elevation of protein excretion into urine. In the ACT-treated rats, cholesterol and creatinine contents and antibody production against rabbit γ-globulin in the plasmas were lower than those of the nephritic control rats. Histological observation demonstrated that this agent suppressed hypercellularity and the incidence of crescent formation, adhesion of capillary wall to Bowmans capsule and fibrinoid necrosis in the glomeruli. Furthermore, rat-IgG and C<SUB>3</SUB> deposits on the GBM were significantly less in the ACT-treated group than in the control nephritic group. When the treatment was started from the 20th day after i.v. injection of anti-GBM serum, by which the disease had been established, ACT resulted in a similar effect on the nephritic rats as stated above. These results suggest that ACT may be a useful medicine against rapidly progressive glomerulonephritis, which is characterized by severe glomerular lesions with diffuse crescents.
著者
-
Nagamatsu Tadashi
Department Of Pharmacobiology And Therapeutics Faculty Of Pharmacy Meijo University
-
Hattori Tomohisa
Department Of Pharmacology Faculty Of Pharmacy Meijo University
-
Hayashi Kazumi
Department Of Pharmacology Faculty Of Pharmacy Meijo University
-
Suzuki Yoshio
Department Of Chemical Science & Technology Faculty Of Engineering Kyushu University
-
Ito Mikio
Department Of Analytical Pharmacology Faculty Of Pharmacy Meijo University
関連論文
- Effects of KD3-671, an Angiotensin II Type 1 Receptor Antagonist, on Anti-Thy-1 Nephritis in Rats
- Involvement of Prostaglandin E_2 in Clearance of Aggregated Protein via Protein Kinase A in Glomeruli
- Thromboxane A_2 Interferes with a Disposal Process of Aggregated Protein in Glomeruli
- Effect of DP - 1904, a Thromboxane A_2 Synthase Inhibitor, Administered from the Autologous Phase on Crescentic-Type Anti-GBM Nephritis in Rats
- Intussusception and spontaneous ileal perforation in Henoch-Schonlein purpura
- ピオグリタゾンは肥満型糖尿病の腎症を改善させる--腎臓の酸化反応を緩和する
- Insufficient Expression of Cyclooxygenase-2 Protein Is Associated With Retarded Degradation of Aggregated Protein in Diabetic Glomeruli
- Increase in the Deposition of Aggregated Protein in the Glomeruli of Spontaneously Diabetic Mice
- Temperature-Induced Phase Transitions in 1,3,5-Trimethylbenzene Crystal
- Acteoside, a Component of Stachys Sieboldii MIQ, May Be a Promising Antinephritic Agent(3): Effect of Acteoside on Expression of Intercellular Adhesion Molecule-1 in Experimental Nephritic Glomeruli in Rats and Cultured Endothelial Cells
- Suppression of Experimental Crescentic-Type Anti-Glomerular Basement Membrane (GBM) Nephritis by FK506 (Tacrolimus Hydrate) in Rats
- The Possible Roles of Hyperlipidemia and Mononuclear Cells in Glomeruli in Puromycin Aminonucleoside Nephrosis in Rats
- PRECLINICAL EVALUATION OF ANTINEPHRITIC DRUGS
- Antiproteinuric Effect of KD3-671, an Angiotensin II Type 1 Receptor Antagonist, in Rats With Accelerated Passive Heymann Nephritis
- Progression of prostate cancer to neuroendocrine cell tumor
- Immunohistochemical finding of α-1-antichymotrypsin in tissues of benign prostatic hyperplasia and prostate cancer
- Induction of Cyclooxygenase-2 Expression in Glomeruli by Aggregated Protein
- Characterization of hyperplastic foci observed in surgical specimens of hepatocellular carcinoma
- Z-335,a Thromboxane A_2 Receptor Antagonist, Suppresses the Progression of Arachidonic Acid-Induced Hind Limb Gangrene in Rats
- Arachidonic Acid-Induced Hind Limb gangrene : A New Experimental Rat Model of Paripheral Vascular Disease
- Modulation of Anti-Glomerular Basement Membrane Nephritis in Rats by ONO-1301, a Non-Prostanoid Prostaglandin I_2 Mimetic Compound with Inhibitory Activity against Thromboxane A_2 Synthase
- Simultaneous Evaluation of Gastric and Duodenal Ulcers-Healing Activities of Anti-ulcer Agents in Rats
- Healing-Promoting Action of the Zinc-Cimetidine Complex on Acetic Acid-Induced Gastric Ulcers in Rats
- MPAI (Mass Probes Aided Ionization) Method for Total Analysis of Biomolecules by Mass Spectrometry
- Semicomprehensive and Semiquantitative Determination of Proteins with Mass Probes
- Safety and Efficacy of Fasudil Monotherapy and Fasudil-Ozagrel Combination Therapy in Patients With Subarachnoid Hemorrhage : Sub-analysis of the Post-marketing Surveillance Study
- Pressure-Induced Phase Transitions in trans-Stilbene Crystals
- Temperature and Pressure Effects on Intermolecular Interactions in Charge Transfer Crystals of 2-(4-Methoxyphenyl)-1,4-benzoquinone and Quinhydrone
- Pressure Effect on Phase Transitions in Hexamethylbenzene Crystals
- Butein Ameliorates Experimental Anti-Glomerular Basement Membrane (GBM) Antibody-Associated Glomerulonephritis in Rats (1)
- Effect of the Intracellular Calcium Antagonist HA1004 on Cerebral Blood Flow in Rats
- NMR Study of Mixed Crystals (CH_3NH_3)_2Cu (Cl_Br_x)_4
- Bromine NMR Study of Cupric Compounds (C_nH_NH_3)_2CuBr_4 (n=1, 2)
- Magnetic Structure of (C_2H_5NH_3)_2CuBr_4
- Differential diuretic effect of Wakan-yaku formulations between physiological and pathological rats
- Studies on the Nephrotoxicity of Aminoglycoside Antibiotics and Protection from These Effects. (5). Interaction of Tobramycin with Latamoxef in Vitro
- Solitary Malignant Schwannoma of the Duodenum with Metastasis to the Liver:Report of a Case
- Balloon Catheter Test in Patients with Atrial Septal Defect and Patent Ductus Arteriosus
- Surveillance and Follow-up of Patients with Implanted Cardiac Pacemaker by Telephone Transmission
- Inhibition of Neutrophil Migration by a Protein Kinase Inhibitor for the Treatment of Ischemic Brain Infarction
- Basal Meningioma. Diagnostic and Therapeutic Considerations
- Temperature- and Pressure-Induced Phase Transitions in p-Difluoro-benzene Crystals
- Pressure- and Temperature-Induced Phase Transitions in 2,4,6-Trichloro-1,3,5-triazine Crystal
- Temperature- and Pressure-Induced Phase Transition in Tetrafluoro-1,4-benzoquinone Crystal
- High Pressure Raman Study of Hexafluorobenzene Crystals
- Hydration and Pressure Effects on the Inter- and Intramolecular Vibrations of Tetramethylpyrazine Crystals
- Pressure-Induced Phase Transition in the 1,2,4,5-Tetrabromobenzene Crystal
- Hyperfine Interactions of Lignad Bromine Nuclei in Ferromagnetic (CH_3NH_3)_2Cu (Cl_Br_x)_4
- Hyperfine Interactions for Cu Nuclei in (C_2H_5NH_3)_2CuCl_4
- Bromine NMR in Ferromagnetic (CH_3NH_3)_2Cu (Cl_Br_x)_4
- STUDIES ON THE MECHANISM OF ACTION OF CETRAXATE [4-(2-CARBOXYETHYL)PHENYL TRANS-4-AMINOMETHYL CYCLOHEXANECARBOXYLATE HYDROCHLORIDE], A NEW ANTI-ULCER AGENT
- Ionophoric Properties of a Doubly-Bridged Calix[8]arene Bearing a Eight-Oxygens Converging Cavity
- Does Bile Spillage During and Operation Present a Risk for Peritoneal Metastasis in Bile Duct Carcinoma?
- Growth Time of the π-Emission in KI in Picosecond Range
- PHARMACOLOGICAL STUDIES ON EXPERIMENTAL NEPHRITIC RATS (4) IMPROVEMENT OF HYPERLIPEMIC MODELS IN RATS UTILIZING ANTI-RAT KIDNEY RABBIT SERUM AND EFFECTS OF ANTI-HYPERLIPEMIC AGENTS ON SERUM LIPID LEVELS
- ALTERATION OF NOREPINEPHRINE RELEASE FROM [3H]-NOREPINEPHRINE PRELOADED BASILAR ARTERY BY NAPHTHALENESULFONAMIDES
- MECHANISM OF RELAXANT ACTIVITIES OF UROTENSIN I, A NEUROPEPTIDE FROM FISH, ON ISOLATED RAT ARTERIES
- BIOCHEMICAL STUDIES ON EXPERIMENTAL STRESS ULCER. I. GASTRIC MUCOSAL HEMORRHAGE AND COAGULATION-FIBRINOLYSIS IN RAT STRESS ULCER
- PHARMACOLOGICAL STUDIES ON EXPERIMENTAL NEPHRITIC RATS (3) CHANGES IN THE CONNECTIVE TISSUE COMPONENTS OF RENAL CORTEX IN THE MODIFIED TYPE OF MASUGIS NEPHRITIS
- Effects of Hypertonic Mannitol on Renal Function in Open Heart Surgery
- Pulsatile Venous Flow in Extracorporeal Circulation
- Pathological study of pseudohypertrophy of the inferior olivary nucleus
- STUDIES ON ANTINEPHRITIC EFFECT OF MIZORIBINE (P-INN, BREDININ®), A NEW IMMUNOSUPPRESSIVE AGENT, AND AZATHIOPRINE (1) EFFECT ON THE NEPHROTIC TYPE OF ANTI-GBM NEPHRITIS IN RATS
- BIOCHEMICAL STUDIES OF ASCIDIAN, CYNTHIA RORETZI V. DRASCHE V. TUNICIN IN TEST
- ANTI-ULCER EFFECTS OF 4-(2-CARBOXYETYL) PHENYL TRANS-4-AMINOMETHYL CYCLOHEXANECARBOXYLATE HYDROCHLORIDE (CETRAXATE) ON VARIOUS EXPERIMENTAL GASTRIC ULCERS IN RATS
- New Formulation of One-body Problem in Quantum Electrodynamics
- PHARMACOLOGICAL STUDIES ON EXPERIMENTAL NEPHRITIC RATS (9). CHANGES IN ACTIVITIES OF URINARY ENZYMES IN THE MODIFIED TYPE OF MASUGIS NEPHRITIS AND THEIR SOURCES
- PHARMACOLOGICAL STUDIES ON EXPERIMENTAL NEPHRITIC RATS (2). ANTINEPHRITIC EFFECT OF VARIOUS DRUGS ON MASUGIS NEPHRITIS
- Parameters of Cu Nuclear Spin Hamiltonian in Mixed Crystals (CH_3NH_3)_2Cu (Cl_Br_x)_4
- Acteoside, a Component of Stachys Sieboldii MIQ, May Be a Promising Antinephritic Agent (2): Effect of Acteoside on Leukocyte Accumulation in the Glomeruli of Nephritic Rats
- Acteoside, a Component of Stachys Sieboldii MIQ, May Be a Promising Antinephritic Agent: Effect of Acteoside on Crescentic-Type Anti-GBM Nephritis in Rats
- Marked Antinephritic. Action and Less Adverse Effects of Methylprednisolone Suleptanate by Intermittent Administration in Rats
- Studies on the Antinephritic Effects of Plant Components (6): Antinephritic Effects and Mechanisms of Phellodendrine (OB-5) on Crescentic-Type Anti-GBM Nephritis in Rats (2)
- Studies on the Antinephritic Effect of Plant Components (4): Reduction of Protein Excretion by Berberine and Coptisine in Rats with Original-Type Anti-GBM Nephritis
- Studies on Antinephritic Effects of Plant Components (3): Effect of Pachyman, a Main Component of Poria Cocos Wolf on Original-Type Anti-GBM Nephritis in Rats and Its Mechanisms
- Suppression by Cyclosporin A of Anti-GBM Nephritis in Rats
- Organosulfur Functionality as an Alternative Enantiocontrollable Coordinating Element in Chiral Phosphine Ligands for Palladium-Catalyzed Asymmetric Allylic Alkylations
- CHANGES IN CONNECTIVE TISSUE COMPONENTS IN ULCER TISSUE DURING THE HEALING PROCESS OF ACETIC ACID ULCER IN RATS
- Myocardial Protection during Cardiac Ischemia by Coronary Perfusion with Cold Lactated Ringers Solution Plus Mannitol
- Studies on Antinephritic Effect of TJ-8014, a New Japanese Herbal Medicine (3): Effects on Crescentic-Type Anti-GBM Nephritis in Rats
- Antinephritic Effects of PGE1 and Thiaprostaglandin E1, TEI-5178 and TEI-6122, on Crescentic-Type Anti-GBM Nephritis in Rats
- Studies on Antinephritic Effect of TJ-8014, a New Japanese Herbal Medicine, and Its Mechanisms (2): Effect on the Release of Corticosterone from Adrenal Glands
- Accelerated Passive Heymann Nephritis in Rats as an Experimental Model for Membranous Glomerulonephritis and Effects of Azathioprine and Prednisolone on the Nephritis
- Antinephritic Effect of Y-19018, a Thromboxane A Synthetase Inhibitor, on Crescentic-Type Anti-GBM Nephritis in Rats
- Effects of Prostaglandin E1 and Dipyridamole on Disposal of Colloidal Carbon via Glomerular Mesangial Channels
- Studies on Antinephritic Effect of Mizoribine (p-INN, Bredinin®), a New Immunosuppressive Agent, and Azathioprine (2) Effect on Crescentic-Type Anti-GBM Nephritis in Rats
- CRESCENTIC TYPE NEPHRITIS INDUCED BY ANTI-GLOMERULAR BASEMENT MEMBRANE (GBM) SERUM IN RATS
- Effects of Experimental Chronic Volume Overloading on Left Ventricular Contractility and Compliance
- Sclerosing odontogenic carcinoma with benign fibro-osseous lesion of the mandible : An extremely rare case report
- MECHANISM OF ACTION OF A NEW ANTI-INFLAMMATORY AGENT, NAPROXEN (II):EFFECTS OF NAPROXEN ON ACTIVITIES OF MUCOPOLYSACCHARASE, ACID PROTEASE AND COLLAGENOLYTIC ENZYMES IN INFLAMED TISSUES
- BIOCHEMICAL STUDIES OF THE ASCIDIAN, CYNTHIA RORETZI v. DRASCHE IV CAROTENOIDS IN TEST
- Studies on experimental immune complex nephritis. 3. Therapeutic effect of prostaglandin E1 .ALPHA.-cyclodextrin host molecule (PGE1CD) on serum sickness nephritis in rats.
- Preventive Actions of N-(3-Aminopropionyl)-L-Histidinato Zinc (Z-103) through Increases in the Activities of Oxygen-Derived Free Radical Scavenging Enzymes in the Gastric Mucosa on Ethanol-Induced Gastric Mucosal Damage in Rats.
- Healing-promoting action of dried aluminium hydroxide gel evaluated by the method of histological measurements in acetic acid ulcer of rats.
- Healing-promoting action of teprenone, a new antiulcer agent on acetic acid ulcer in rats.
- A study of nutritional management records for patients on dialysis
- Antinephritic effect of prostaglandin E1 on serum sickness nephritis in rats. (5). Effect of PGE1 on disposal of heat-aggregated bovine serum albumin in the glomerulus.
- Antinephritic effect of prostaglandin E1 on serum sickness nephritis in rats. (4). Enhanced clearance of macromolecules by the reticulo-endothelial system with prostaglandin E1.
- Studies on antinephritic effect of TJ-8014, a new Japanese herbal medicine (4): effects on accelerated passive Heymann nephritis in rats.
- Thromboxane A2 Interferes with a Disposal Process of Aggregated Protein in Glomeruli.