Studies on Antinephritic Effects of Plant Components (3): Effect of Pachyman, a Main Component of <I>Poria Cocos</I> Wolf on Original-Type Anti-GBM Nephritis in Rats and Its Mechanisms
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概要
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The antinephritic effect of pachyman on original-type anti-GBM nephritis in rats was investigated. Pachyman was given to original-type anti-GBM nephritic rats for 10 days from the day of anti-GBM serum injection. Pachyman prevented urinary protein excretion and the elevation of serum cholesterol content. Histopathological observations of the glomeruli indicated that although the number of nuclei and adhesion to capillary walls of Bowmans capsule in nephritic control rats were significantly increased, pachyman reduced the degree of histopathological changes such as hypercellularity and adhesion as compared to the control group. Although the serum complement CH<SUB>50</SUB> ratio in control group was significantly lower than that in the normal group, the decrease in serum complement CH<SUB>50</SUB> was inhibited by pachyman, and rat C<SUB>3</SUB> deposition in the glomeruli in the pachyman-treated group was significantly reduced. These results suggest that pachyman was effective against original-type anti-GBM nephritis in rats and that the antinephritic mechanisms of pachyman may be partly due to the inhibitory action of this agent on C<SUB>3</SUB> deposition in the glomeruli.
著者
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Nagao Toshiyuki
Department Of Pharmacology Faculty Of Pharmacy Meijo University
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Hattori Tomohisa
Department Of Pharmacology Faculty Of Pharmacy Meijo University
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HAYASHI Kazumi
Department of Pharmacology, Faculty of Pharmacy, Meijo University
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Hayashi Kazumi
Department Of Pharmacology Faculty Of Pharmacy Meijo University
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Furuta Kazuya
Department Of Materials Science Faculty Of Science Hiroshima University
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Suzuki Yoshio
Department Of Chemical Science & Technology Faculty Of Engineering Kyushu University
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Ito Mikio
Department Of Analytical Pharmacology Faculty Of Pharmacy Meijo University
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