Antiproliferative Constituents in Plants 9. Aerial Parts of Lippia dulcis and Lippia canescens
スポンサーリンク
概要
- 論文の詳細を見る
The antiproliferative constituents in the MeOH extracts of the aerial parts of Lippia dulcis TREV. and Lippia canescens KUNTH (Verbenaceae) were investigated. Activity-guided chemical investigation of the MeOH extracts resulted in the isolation of the three bisabolane-type sesquiterpenes [(+)-hernandulcin (1), (-)-epihernandulcin (2), and (+)-anymol (3)] and four phenylethanoid glycosides [acteoside (4), isoacteoside (5), martynoside (6), and a new diacetylmartynoside (7)] from the former, and four phenylethanoid glycosides [acteoside (4), isoacteoside (5), arenarioside (8), and leucosceptoside A (9)] and three flavones [desmethoxycentaureidin (10), eupafolin (11), and 6-hydroxyluteolin (12)] from the latter. Antiproliferative activity of the isolated compounds against murine melanoma (B16F10), human gastric adenocarcinoma (MK-1), and human uterine carcinoma (HeLa) cells was estimated. (+)-Anymol (3), acteoside (4), isoacteoside (5), arenarioside (8), eupafolin (11), and 6-hydroxyluteolin (12) had GI_50 values of 10-16μM against B16F1O cell. Desmethoxycentaureidin (10) and eupafolin (11) showed high inhibitory activity against HeLa cell growth (GI_50 9μM, and 6 μM, respectively).
- 公益社団法人日本薬学会の論文
- 2002-07-01
著者
-
Nagao Toshiyuki
Department Of Pharmacology Faculty Of Pharmacy Meijo University
-
岡部 光
Faculty Of Pharmaceutical Sciences Fukuoka University
-
阿部 フミ子
Faculty Of Pharmaceutical Sciences Fukuoka University
-
ABE Fumiko
Faculty of Pharmaceutical Sciences, Fukuoka University
-
OKABE Hikaru
Faculty of Pharmaceutical Sciences, Fukuoka University
-
NAGAO Tsuneatsu
Faculty of Pharmaceutical Sciences, Fukuoka University
-
Okabe Hikaru
Faculty Of Pharmaceutical Sciences Fukuoka University
-
岡部 光
福岡大学
-
Okabe Hikaru
福岡大学 薬学部
-
岡部 光
福岡大学薬学部
-
Abe Fumiko
Faculty Of Pharmaceutical Science Fukuoka University
-
Nagao T
Faculty Of Pharmaceutical Sciences Fukuoka University
-
Nagao Tsuneatsu
Faculty Of Pharmaceutical Sciences Fukuoka University
関連論文
- Protective Effect of Prostaglandin EP_4-Receptor Agonist on Anti-glomerular Basement Membrane Antibody-Associated Nephritis
- Microbial transformation and bioactivation of isoflavones from Pueraria flowers by human intestinal bacterial strains
- Cyclodextrin-Enclosed Substances of Brazilian Propolis
- Two Novel Long-Chain Alkanoic Acid Esters of Lupeol from Alecrim-Propolis
- Flavonoids from Brazilian Propolis
- A new diterpenoid and a new triterpenoid glucosyl ester from the leaves of Callicarpa japonica Thunb. var. luxurians Rehd.
- A new lignan glucoside from the stems of Callicarpa japonica Thunb. var. luxurians Rehd.
- Five New Diterpenoids, Viteagnusins A-E, from the Fruit of Vitex agnus-castus
- A new phenylethanoid glycoside from the fruits of Callicarpa japonica Thunb. var. luxurians Rehd.
- Two New 15, 16-Seco-cycloartane Glycosides from Cimicifuga Rhizome
- Four New Cycloartane Glycosides from Aquilegia vulgaris and Their Immunosuppressive Activities in Mouse Allogeneic Mixed Lymphocyte Reaction
- Three Cycloartane Glycosides from Cimicifuga Rhizome and Their Immunosuppressive Activities in Mouse Allogeneic Mixed Lymphocyte Reaction
- Studies on the Constituents of Gueldenstaedtia multiflora
- Three New Monoterpenoids from the Fruit of Genipa americana
- Four New Triterpene Glycosides from Nigella damascena
- New Iridoid Glucosides from the Aerial Parts of Verbena brasiliensis
- ウスバサイシンAsiasarum sieboldii F. Maekawaの発芽特性
- Anti-herpes Virus Type 1 Activity of Oleanane-Type Triterpenoids(Pharmacognosy)
- New Bisabolane-Type Sesquiterpenes from the Aerial Parts of Lippia dulcis
- Examination for Estrogenic Activities of Soyasaponin I and Related Compounds
- A New Lignan Glycoside and Phenylethanoid Glycosides from Strobilanthes cusia BREMEK
- Soy Isoflavone Metabolites Isolated from Human Urine
- Pregnane- and Furostane-Type Oligoglycosides from the Seeds of Allium tuberosum
- Steroids from the Underground Parts of Trillium kamtschaticum
- Hepatoprotective Constituents in Plants 14. Effects of Soyasapogenol B, Sophoradiol, and Their Glucuronides on the Cytotoxicity of tert-Butyl Hydroperoxide to HepG2 Cells(Pharmacognosy)
- Four New Cycloartane Glycosides from Aquilegia vulgaris
- Sesquiterpenoids, Triterpenoids, and Flavonoids from the Fruits of Schinus molle
- DPPH radical-scavenging effect on some constituents from the aerial parts of Lippia triphylla
- Two new lignan glucosides from the fruit of Vitex cannabifolia
- Two Novel Antioxidant Ortho-Benzoyloxyphenyl Acetic Acid Derivatives from the Fruit of Vaccinium uliginosum
- Two New Steroid Glycosides and a New Sesquiterpenoid Glycoside from the Underground Parts of Trillium kamtschaticum
- Iridoid Glucosides from the Fruit of Genipa americana
- Antioxidative, Antihyaluronidase and Antityrosinase Activities of Some Constituents from the Aerial Part of Piper elongatum VAHL.
- Evaluation of the Anti-oxidative Effect (in vitro) of Tea Polyphenols(Organic Chemistry)
- A New Triterpene Glucosyl Ester from the Fruit of the Blackberry (Rubus allegheniensis)
- Antioxidant Ortho-Benzoyloxyphenyl Acetic Acid Ester, Vaccihein A, from the Fruit of Rabbiteye Blueberry (Vaccinium ashei)
- New Megastigmane Glycoside and Aromadendrane Derivative from the Aerial Part of Piper elongatum
- Antioxidative and Antihyaluronidase Activities of Some Constituents from the Aerial Part of Daucus carota
- Antiproliferative Activity of the Main Constituents from Phyllanthus emblica
- Effects of KD3-671, an Angiotensin II Type 1 Receptor Antagonist, on Anti-Thy-1 Nephritis in Rats
- Involvement of Prostaglandin E_2 in Clearance of Aggregated Protein via Protein Kinase A in Glomeruli
- Thromboxane A_2 Interferes with a Disposal Process of Aggregated Protein in Glomeruli
- Effect of DP - 1904, a Thromboxane A_2 Synthase Inhibitor, Administered from the Autologous Phase on Crescentic-Type Anti-GBM Nephritis in Rats
- ピオグリタゾンは肥満型糖尿病の腎症を改善させる--腎臓の酸化反応を緩和する
- Insufficient Expression of Cyclooxygenase-2 Protein Is Associated With Retarded Degradation of Aggregated Protein in Diabetic Glomeruli
- Increase in the Deposition of Aggregated Protein in the Glomeruli of Spontaneously Diabetic Mice
- Three New Acyclic Diterpene Glycosides from the Aerial Parts of Paprika and Pimiento
- Acyclic Diterpene Glycosides, Capsianosides C,D,E,F and III, from the Fruits of Hot Red Pepper Capsicum annuum L. Used in Kimchi and Their Revised Structures
- Studies on the chemical constituents of green leaves of Eucommia ulmoides Oliv.
- Physiological functions of solanaceous and tomato steroidal glycosides
- Acyclic Diterpene Glycosides, Capsianosides VIII, IX, X, XIII, XV and XVI from the Fruits of Paprika Capsicum annuum L. var. grossum BAILEY and Jalapeno Capsicum annuum L. var. annuum
- P-229 NEW STEROIDAL GLYCOSIDES FROM TUBOCAPSICUM ANOMALUM
- Tomato New Sapogenols : Isoesculeogenin A and Esculeogenin B
- Four Novel Withanolide-Type Steroids from the Leaves of Solanum cilistum
- Antiproteinuric Effect of KD3-671, an Angiotensin II Type 1 Receptor Antagonist, in Rats With Accelerated Passive Heymann Nephritis
- Microbial metabolism of soy isoflavones by human intestinal bacterial strains
- Two New Cycloartane Glycosides from the Underground Parts of Aquilegia vulgaris
- A New Steroidal Glycoside and a New Phenyl Glycoside from a Ripe Cherry Tomato
- New C_ Steroidal Glycosides from Tubocapsicum anomalum
- A New Homostilbene and Two New Homoisoflavones from the Bulbs of Scilla scilloides
- Mechanism for Conversion of Spirosolane Derivative into Pregnane
- A Pregnane Glycoside from Overripe Tomato
- Two Labdane Diterpene and Megastigmane Glycosides from Aquilegia hybrida
- Conversion of Esculeoside A into Esculeogenin B
- Antiproliferative Constituents from Umbelliferae Plants VII. Active Triterpenes and Rosmarinic Acid from Centella asiatica(Pharmacognosy)
- Three New Steroid Glycosides from the Underground Parts of Trillium kamtschaticum
- Three New 15,16-Seco-cycloartane Glycosides from Cimicifuga Rhizome
- New C_ Steroidal Glycosides from Tubocapsicum anomalum
- Two New 15-Deoxycimigenol-Type and Three New 24-epi-Cimigenol-Type Glycosides from Cimicifuga Rhizome
- Steroidal Alkaloid Glycosides, Esculeosides C and D, from the Ripe Fruit of Cherry Tomato
- Antiproliferative Sesquiterpene Lactones from the Roots of Inula helenium(Pharmacognosy)
- Interactions of Phytoestrogens with Estrogen Receptors α and β(III). Estrogenic Activities of Soy Isoflavone Aglycones and Their Metabolites Isolated from Human Urine(Toxicology)
- Ursolic Acid as a Trypanocidal Constituent in Rosemary
- Activity-Guided Fractionation of Green Tea Extract with Antiproliferative Activity against Human Stomach Cancer Cells
- Antiproliferative Constituents in Plants 9. Aerial Parts of Lippia dulcis and Lippia canescens
- Antiproliferative Constituents in Plants 10. Flavones from the Leaves of Lantana montevidensis BRIQ. and Consideration of Structure-Activity Relationship
- Efficient Conversion of Tomatidine into Neuritogenic Pregnane Derivative
- Metabolism of Tomato Steroidal Glycosides in Humans
- P-297 ANTI-FOAM CELL FORMATION OF ESCULEOGENIN A, A NOVEL STEROIDAL ALKALOID ISOLATED FROM TOMATO
- P-263 NOVEL TOMATO STEROIDAL GLYCOSIDES
- Cytotoxic Major Saponin from Tomato Fruits (Communications to the Editor)
- Cytotoxic Triterpenes and Sterol from the Fruit of Rabbiteye Blueberry (Vaccinium ashei)
- Ursolic Acid as a Trypanocidal Constituent in Rosemary
- Antiproliferative Constituents in the Plants 7. Leaves of Clerodendron bungei and Leaves and Bark of C. trichotomum^
- Induction of Cyclooxygenase-2 Expression in Glomeruli by Aggregated Protein
- Cytotoxic Activity of Steroidal Glycosides from Solanum Plants(Pharmacognosy)
- Five Triterpene Glycosides from Oxytropis myriophylla
- Four New Halimane-Type Diterpenes, Vitetrifolins D-G, from the Fruit of Vitex trifolia
- Distinction of Absolute Configuration at C-22 of C-23-Hydroxyspirostane and C-23-Hydroxyspirosolane Glycosides
- P-276 ANTIOBESITY EFFECTS OF GREEN LEAVES OF EUCOMMIA AND THEIR CHEMICAL CONSTITUENTS
- Antiproliferative Constituents in the Plant 8. Seeds of Rhynchosia volubilis
- The detection and quantification of highly reactive oxygen species using the novel HPF fluorescence probe in a rat model of focal cerebral ischemia
- A Novel Fluorescent Probe for Zinc Ion Based on Boron Dipyrromethene (BODIPY) Chromophore
- Antiproliferative Constituents from Umbelliferae Plants. IX. New Triterpenoid Glycosides from the Fruits of Bupleurum rotundifolium
- Antiproliferative Constituents from Umbelliferae Plants VI. New Ursane-Type Saikosaponin Analogs from the Fruits of Bupleunim rotundifolium
- DPPH(1, 1-Diphenyl-2-Picrylhydrazyl)Radical Scavenging Activity of Flavonoids Obtained from Some Medicinal Plants
- Interaction of Phytoestrogens with Estrogen Receptors α and β
- Three Unusual 22-β-O-23-Hydroxy-(5α)-spirostanol Glycosides from the Fruits of Solanum torvum
- Two New Tetranor-Cycloartane Glycosides from Cimicifuga Rhizome
- Four New 26-Aminocholestane-Type Glycosides from Solanum abutiloides