Studies on experimental immune complex nephritis. 3. Therapeutic effect of prostaglandin E1 .ALPHA.-cyclodextrin host molecule (PGE1CD) on serum sickness nephritis in rats.
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概要
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The effect of prostaglandin E<SUB>1</SUB> α-cyclodextrin host molecule (PGE<SUB>1</SUB>·CD) was estimated by using a model of immune complex glomerulonephritis induced in rats by i.v. injection of 1 mg of rabbit serum albumin every other day. PGE<SUB>1</SUB>·CD was given subcutaneously for 10 days after nephritis was definitely induced and resulted in a rapid restoration of various biochemical parameters, especially in plasma. The continuous s.c. administration of PGE<SUB>1</SUB>·CD (300 μg/rat/day) with a mini osmotic pump provoked a therapeutic effect similar to that obtained with twice daily s.c. administration of PGE<SUB>1</SUB>·CD (300 μg/rat×2/day). Both PGE<SUB>1</SUB>·CD groups revealed less glomerular damage and fewer locations of immune complexes in glomeruli as demonstrated by light and immunofluorescence microscopy. The beneficial effect of PGE<SUB>1</SUB>·CD may be associated with reduced immune complex deposits in glomeruli. The present studies suggest that PGE<SUB>1</SUB>·CD may enhance the clearance of immune complex deposits from the glomeruli rather than inhibiting the formation of immune complex in the circulation.
- 公益社団法人 日本薬理学会の論文
著者
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Nagamatsu Tadashi
Department Of Pharmacobiology And Therapeutics Faculty Of Pharmacy Meijo University
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Saitoh Naoto
Department Of Aerospace Engineering Tokyo Metropolitan Institute Of Technology
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Suzuki Yoshio
Department Of Chemical Science & Technology Faculty Of Engineering Kyushu University
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NAGAMATSU Tadashi
Department of Pharmacology, Faculty of Pharmacy, Meijo University
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IKUTA Kouji
Second Department of Pathology, Aichi Medical School
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AOKI Shigehisa
Second Department of Pathology, Aichi Medical School
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