Effects of Hypertonic Mannitol on Renal Function in Open Heart Surgery
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概要
- 論文の詳細を見る
An extracorporeal bypass was performed in mongrel dogs for 2 hours with or without hypertonic mannitol infusions. In animals given mannitol, the plasma osmolality was elevated maximally to 344±7.1mOsm/L and the urine volume was maintained well during bypass. A hypertonic mannitol solution was effective in maintaining the CPAH during and after bypass, but was not effective in minimizing the reduction in Ccr. When the mean arterial pressure during bypass was kept at 60mmHg, the carbon filling rates in glomeruli showed the favorable effects of mannitol upon renal function, but no effects were observed at a mean arterial pressure of 80mmHg. In 11 patients who had undergone a bypass lasting more than 2hrs with mannitol infusions, the plasma osmolality reflected the serum mannitol level and reached 320±11.0mOsm/L at 150min of bypass. The mean urine volume was 5.0±3.3ml/min/M2 during the bypass, which was about 7 times as great as before the bypass. The Ccr increased during the first 30min of the bypass, but it fell to about one half of the initial value after 90min of the bypass. It was concluded that a hypertonic mannitol solution is effective in maintaining the RPF and urine volume during and after the bypass and that it also preserved the glomerular perfusion even at a low arterial pressure.
- International Heart Journal刊行会の論文
著者
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SUZUKI Yoshio
Department of Pharmacology, Faculty of Pharmacy, Meijo University
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Nishimura Osamu
Department of Electronics and Computer Science
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ENOMOTO Katsumi
Department of Surgery, Koyo Hospital
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Yokoi Hideki
Department of Biochemistry, College of Agriculture, Kyoto Prefectural University
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Kodama Ken
Department Of Surgery Osaka Medical Center For Cancer And Cardiovascular Diseases
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OKADA Naniwa
Department of Thoracic Surgery, Wakayama Medical College
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TOKUTSU Shuichi
Department of Thoracic Surgery, Wakayama Medical College
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TAKIMOTO Motoyuki
Department of Thoracic Surgery, Wakayama Medical College
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OHTA Hisao
Department of Thoracic Surgery, Wakayama Medical College
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YAMAOKA Yoshiyuki
Department of Thoracic Surgery, Wakayama Medical College
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Okada Kazuo
Department Of Anesthesiology School Of Medicine Teikyo University
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Sakurai Takeo
Department Of Aeronautical Engineering Faculty Of Engineering Kyoto University
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Nishimura Osamu
Department Of Earth Science And Astronomy College Of Arts And Sciences The University Of Tokyo
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Enomoto Katsumi
Department Of Surgery Koyo Hospital
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Suzuki Yoshio
Department Of Chemical Science & Technology Faculty Of Engineering Kyushu University
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Kodama Ken
Department Of Immunology Osaka Medical Center For Cancer
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SAKURAI Takeo
Department of Thoracic Surgery, Wakayama Medical College
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YAMAOKA Yoshiyuki
Department of Thoracic and Cardiovascular Surgery, Wakayama Medical College
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TAKIMOTO Motoyuki
Department of Thoracic and Cardiovascular Surgery, Wakayama Medical College
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TOKUTSU Shuichi
Department of Thoracic and Cardiovascular Surgery, Wakayama Medical College
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OHTA Hisao
Department of Thoracic and Cardiovascular Surgery, Wakayama Medical College
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OKADA Naniwa
Department of Thoracic and Cardiovascular Surgery, Wakayama Medical College
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NISHIMURA Osamu
Department of Civil and Environmental Engineering, Tohoku University, Japan
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