Pulmonary Shunting during Venovenous Bypass

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Using mongrel dogs, an experimental study was performed to investigate Qs/Qt during v-v bypass with or without oxygenation. During bypass, the systemic circulation was maintained under constant conditions, while bypass flow rate, Svo2 and Pvco2 varied independently.The results were as follows:1) In dogs undergoing v-v bypass without oxygenation, Qs/Qt and A-aDO2 increased markedly in proportion to bypass flow in animals receiving blood infusion into the right ventricle, but a remarkable increase was not seen in animals receiving blood infusion into the right atrium. The pulmonary artery waveform appeared to influence Qs/Qt.2) A significant positive correlation was found between Qs/Qt and Svo2. A-aDO2 showed no correlation to Svo2.3) The Qs/Qt showed no remarkable changes despite significant changes in Pvco2 (from 22 to 96mmHg).4) With regard to Qs/Qt and Svo2, it may be proper to perform v-v bypass at a flow rate of 30ml/Kg/min with blood infusion into the right atrium.
International Heart Journal刊行会の論文