Genetic Polymorphism of C452T (T127I) in Humanγ-Glutamyl Hydrolase in a Japanese Population(Biopharmacy)
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概要
- 論文の詳細を見る
We investigated the genotype distribution and allele frequency of C452T polymorphism of γ-glutamyl hydrolase (GGH) gene, which causes the decreased enzymatic activity affecting the efficacy of methotrexate (MTX), in a Japanese population. The polymerase chain reaction-restriction fragment length polymorphism assay was applied to determine the genotype of C452T polymorphism in 269 Japanese healthy individuals. The genotype distribution was as follows: C/C, 89.2% (n=240); C/T, 10.4% (n=28); T/T, 0.4% (n=1). The frequency of C and T allele was 0.944 and 0.056, respectively. The obtained genotype distribution was well agreed with those expected by Hardy-Weinberg equilibrium. The genotype distribution and allele frequency in a Japanese population were found to be similar to those of African-Americans but significantly different from Caucasians. Although the frequency of variant T allele in a Japanese population is not so high as compared to Caucasians, determination of C452T polymorphism of GGH may be useful for monitoring of efficacy and side-effects of MTX for treatment of diseases such as rheumatoid arthritis or childhood acute leukemia. To our knowledge, this is the first report about the examination of C452T polymorphism of GGH in a Japanese population.
- 公益社団法人日本薬学会の論文
- 2007-04-01
著者
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SUZUKI Toshio
Department of Animal Science, Faculty of Agriculture, Utsunomiya University
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ITOH Kunihiko
Department of Clinical Pharmacology and Genetics, School of Pharmaceutical Science, University of Sh
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HAYASHI Hideki
Department of Organic and Polymeric Materials, Tokyo Institute of Technology
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INOUE Kazuyuki
Department of Clinical Pharmacology and Genetics, School of Pharmaceutical Sciences, University of S
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SHISHIDO Takao
Molecular Cell Biology Laboratory, Graduate School of Pharmaceutical Sciences, Tohoku University
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Hayashi Hideki
Department Of Clinical Pharmacology And Genetics School Of Pharmaceutical Sciences University Of Shi
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FUJIMAKI CHIHIRO
Department of Clinical Pharmacology and Genetics, School of Pharmaceutical Sciences, University of S
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Suzuki Takehiro
Department Of Pharmaceutical Science Akita University Hospital
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Suzuki Toshio
Department Of Pharmaceutical Science Akita University Hospital
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Itoh Kunihiko
Department Of Clinical Pharmacology And Genetics School Of Pharmaceutical Sciences University Of Shi
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Inoue Kazuyuki
Department Of Clinical Pharmacology And Genetics School Of Pharmaceutical Sciences University Of Shi
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井上 勝央
名古屋市立大学大学院薬学研究科薬物動態制御学分野
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Hayashi Hideki
Priority Organization For Innovation And Excellence Kumamoto Univ.
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Hayashi Hideki
Department Of Clinical Pharmacology & Genetics School Of Pharmaceutical Sciences University Of S
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Itoh Kunihiko
Department Of Clinical Pharmacology & Genetics School Of Pharmaceutical Sciences University Of S
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Shishido T
Department Of Pharmaceutical Science Akita University Hospital
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Suzuki Toshio
Department Of Agronomy Faculty Of Agriculture Tohoku University
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Suzuki Toshio
Department Of Metallurgy And Materials Science School Of Engineering The University Of Tokyo
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Inoue Kazuyuki
Department Of Clinical Pharmacology & Genetics School Of Pharmaceutical Sciences University Of S
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Hayashi Hideki
Department Of Cardiovascular And Respiratory Medicine Shiga University Of Medical Science
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Fujimaki Chihiro
Department Of Clinical Pharmacology And Genetics School Of Pharmaceutical Sciences University Of Shi
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Suzuki Takehiro
Department Of Urology Akita University School Of Medicine
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Hayashi Hideki
Department Of Academic Surgery Chiba University Graduate School Of Medicine
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Hayashi Hideki
Department Clinical Pharmacology & Genetics, School of Pharmaceutical Sciences, University of Shizuoka
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Itoh Kunihiko
Department Clinical Pharmacology & Genetics, School of Pharmaceutical Sciences, University of Shizuoka
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Inoue Kazuyuki
Department Clinical Pharmacology & Genetics, School of Pharmaceutical Sciences, University of Shizuoka
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