Arachidonic Acid-Induced Hind Limb gangrene : A New Experimental Rat Model of Paripheral Vascular Disease

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概要

• 論文の詳細を見る

• The purpose of this study was to investigate the characteristics of arachidonic acid-induced peripheral vascular disease in rats. Injecting arachidonic acid (2 mg/leg) into the femoral artery caused hind limb gangrene. Histopathological examination revealed occlusive thrombi and marked vascular injury, including denudation of the endothelium and degeneration of the media in the paw arteries. Arachidonic acid injection markedly enhanced the platelet response to both U-46619 and collagen. Although the number of circulating platelets did not differ between sham-operation rats and arachidonic acid-injected rats, the numbers of circulating white blood cells and red blood cells were raised 10 d after arachidonic acid injection. Thrombocytopenia, induced before arachidonic acid injection, markedly suppressed arachidonic acid-induced hind limb gangrene in rats. In addition, the combined administration of aspirin (100 mg/kg/d, p.o.) and ticlopidine (300 mg/kg/d, p.o.) prevented the progression of arachidonic acid-induced hind limb gangrene. These results suggest that platelets are involved in the progression of arachidonic acid-induced hind limb gangrene. This experimental rat model may be suitable for developing novel drugs for the treatment of peripheral vascular disease.

• 公益社団法人日本薬学会の論文
• 1999-03-15

著者

• Suzuki Y

  School Of Pharmaceutical Sciences University Of Shizuoka

• Takei Mineo

  Central Research Laboratories, Zeria Pharmaceutical Co., Ltd.

• Suzuki Y

  Fukuoka Inst. Technol. Fukuoka

• Takei M

  Central Research Laboratories Zeria Pharmaceutical Co. Ltd.

• Takei Mineo

  Central Research Laboratories Zeria Pharmaceutical Co. Ltd.

• Suzuki Y

  Meijo Univ. Nagoya Jpn

• SUZUKI Yoshio

  Department of Pharmacology, Faculty of Pharmacy, Meijo University

• Suzuki Y

  Department Of Pharmacobiology And Therapeutics Faculty Of Pharmacy Meijo University

• Suzuki Y

  Core Research For Evolutional Science And Technology (crest Jst) University Of Shizuoka School Of Ph

• KURIMOTO Tadashi

  Central Rsearch Laboratories, Zeria Pharmaceutical Co., Ltd.

• ITO Shigeru

  Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University

• TAMAKI Hajime

  Laboratories of Applied Biochemistry, Faculty of Agriculture, University of the Ryukyus

• FUKUDA Youichi

  Central Research Laboratories, Zeria Pharmaceutical Co., Ltd.

• HIGASHINO Raita

  Central Research Laboratories, Zeria Pharmaceutical Co., Ltd.

• FUKUTA Yoshihisa

  Central Research Laboratories, Zeria Pharmaceutical Co., Ltd.,

• ITO Shigeru

  Central Research Laboratories, Zeria Pharmaceutical Co., Ltd.,

• TAMAKI Hajime

  Central Research Laboratories, Zeria Pharmaceutical Co., Ltd.,

• TANAKA Takao

  Central Research Laboratories, Zeria Pharmaceutical Co., Ltd.

• NOMURA Yosuke

  Central Research Laboratories, Zeria Pharmaceutical Co., Ltd.

• Ito S

  Institute For Medical And Dental Engineering Tokyo Medical And Dental University

• Tanaka T

  School Of Pharmaceutical Sciences Nagasaki University

• Suzuki Y

  Faculty Of Pharmacy Meijo University

• Fukuda Y

  Central Research Laboratories Zeria Pharmaceutical Co. Ltd.

• Tamaki Hajime

  The Third Department Of Internal Medicine Tokyo Medical And Dental University

• Tamaki Hajime

  Central Research Laboratories Zeria Pharmaceutical Co. Ltd.

• Tamaki Hajime

  Chemistry And Technology Of Plant Products Laboratory Kobe University

• Nomura Y

  Central Research Laboratories Zeria Pharmaceutical Co. Ltd.

• Higashino R

  Central Research Laboratories Zeria Pharmaceutical Co. Ltd.

• Kurimoto T

  Zeria Pharmaceutical Co. Ltd. Saitama Jpn

• Kurimoto Tadashi

  Central Rsearch Laboratories Zeria Pharmaceutical Co. Ltd.

• Tanaka Takao

  Third Division Department Of Internal Medicine Osaka Medical College

• 福田 陽一

  Kyoto Pharmaceutical University

• 福田 陽一

  小城製薬株式会社研究所

• Suzuki Yoshio

  Department Of Electronics Fukuoka Institute Of Technology

• Suzuki Y

  Department Of Pharmacology Faculty Of Pharmacy Meijo University

• Suzuki Yoshio

  Department Of Chemical Science & Technology Faculty Of Engineering Kyushu University

• KURIMOTO Tadashi

  Central Research Laboratories, Zeria Pharmaceutical Co., Ltd.

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