Hormonal Effects of Z-350, Possessing Steroid 5α-Reductase Inhibitory and α_1-Adrenoceptor Antagonistic Actions, in the Rat

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概要

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• We examined the hormonal effects of Z-350, (S)-4-[3-(4-{1-(4-methylphenyl)-3-[4-(2-methoxyphenyl)piperazine-1-yl]propoxy}benzoyl)indole-1-yl]butyric acid hydrochloride, which has both α1-adrenoceptor blocking activity and steroid 5α-reductase inhibitory activity, in male and female rats. Z-350 administered orally for 14 days at a dose of 30 mg/kg to normal male rats significantly reduced the weight of the prostate and seminal vesicles without affecting the weight of the testis, epididymis, adrenals, kidney or liver. Prostatic levels of dihydrotestosterone decreased dose-dependently, with a slight increase in the level of testosterone at a Z-350 dose of 100 mg/kg. We observed no effects on the weight of the prostate in castrated rats or on the weight of the uterus in normal or 17β-estradiol-treated female rats. These results suggest that Z-350 inhibits prostatic growth via inhibition of steroid 5-reductase without other hormonal effects.

• 社団法人 日本薬理学会の論文
• 2001-07-01

著者

• Takei Mineo

  Central Research Laboratories, Zeria Pharmaceutical Co., Ltd.

• Takei M

  Central Research Laboratories Zeria Pharmaceutical Co. Ltd.

• Takei Mineo

  Central Research Laboratories Zeria Pharmaceutical Co. Ltd.

• KURIMOTO Tadashi

  Central Rsearch Laboratories, Zeria Pharmaceutical Co., Ltd.

• FUKUDA Youichi

  Central Research Laboratories, Zeria Pharmaceutical Co., Ltd.

• FUKUDA Yoshihisa

  Central Research Laboratories, Zeria Pharmaceutical Co., Ltd.

• HIGASHINO Raita

  Central Research Laboratories, Zeria Pharmaceutical Co., Ltd.

• YOSHIDA Kenji

  Central Research Laboratories, Zeria Pharmaceutical Co., Ltd.

• OGISHIMA Masayuki

  Central Research Laboratories, Zeria Pharmaceutical Co., Ltd.

• FUKUTA Yoshihisa

  Central Research Laboratories, Zeria Pharmaceutical Co., Ltd.,

• Fukuda Y

  Central Research Laboratories Zeria Pharmaceutical Co. Ltd.

• Higashino R

  Central Research Laboratories Zeria Pharmaceutical Co. Ltd.

• Kurimoto T

  Zeria Pharmaceutical Co. Ltd. Saitama Jpn

• Kurimoto Tadashi

  Central Rsearch Laboratories Zeria Pharmaceutical Co. Ltd.

• 福田 陽一

  Kyoto Pharmaceutical University

• 福田 陽一

  小城製薬株式会社研究所

• Ogishima Masayuki

  Central Research Laboratories Zeria Pharmaceutical Co. Ltd.

• Yoshida Kenji

  Central Research Laboratories Zeria Pharmaceutical Co. Ltd.

• KURIMOTO Tadashi

  Central Research Laboratories, Zeria Pharmaceutical Co., Ltd.

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