Inhibition of DNA Topoisomerases by Nidulalin A Derivatives

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概要

• 論文の詳細を見る

• Three cytotoxic dihydroxanthone derivatives, nidulalin A(1), F380B(2), and F390C(3) were evaluated for inhibitory activity against DNA topoisomerases. Compounds 1 and 2 inhibited DNA topoisomerase II with IC_<50> values of 2.2 μM and 16 μM, and 3 inhibited DNA topoisomerase I with an IC_<50> value of 5.9 μM.

• 公益社団法人日本薬学会の論文
• 2000-04-01

著者

• 佐藤 真治

  新潟薬科大学 薬理

• Umemura Ken

  Department Of Bioengineering Faculty Of Engineering Soka University

• Sato S

  Pharmaceutical Research Laboratories Ajinomoto Co. Inc.

• Tsuji T

  Microbiology Faculty Of Pharmaceutical Sciences Hoshi University

• Fukuda Y

  Central Research Laboratories Zeria Pharmaceutical Co. Ltd.

• Andoh Toshiro

  Pharmaceutical Research Laboratories Ajinomoto Co. Inc.

• SATO Seiichi

  Pharmaceutical Research Laboratories, Ajinomoto Co., Inc.

• FUKUDA Yumiko

  Pharmaceutical Research Laboratories, Ajinomoto Co., Inc.,

• NAKAGAWA Ryusuke

  Pharmaceutical Research Laboratories, Ajinomoto Co., Inc.,

• TSUJI Takashi

  Pharmaceutical Research Laboratories, Ajinomoto Co., Inc.,

• ANDOH Toshiro

  Department of Bioengineering, Faculty of Engineering, Soka University

• 佐藤 眞治

  Pharmaceutical Research Laboratories Ajinomoto Co. Inc.

• Sato Seiichi

  Pharmaceutical Research Laboratories Ajinomoto Co. Inc.

• Nakagawa Ryusuke

  Pharmaceutical Research Laboratories Ajinomoto Co. Inc.

• Nakagawa Ryusuke

  Pharmaceutical Research Laboratories Ajinomoto Co. Inc

• Andoh Toshiro

  Department Of Bioengineering Faculty Of Engineering Soka University

• 福田 陽一

  Kyoto Pharmaceutical University

• 福田 陽一

  小城製薬株式会社研究所

• Tsuji Takashi

  Pharmaceutical Research Laboratories Ajinomoto Co. Inc.

• Sato Shinji

  Department Of Pharmaceutics Niigata College Of Pharmacy

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