Uptake of Enalapril by Rabbit Small Intestinal Brush-Border Membrane Vesicles
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概要
- 論文の詳細を見る
Uptake of the angiotensin-converting enzyme (ACE) inhibitor enalapril by rabbit small intestinal brush border membrane vesicles was examined. In the presence of an inward H^+ gradient the uptake of this peptide mimetic drug was accelerated and an overshoot phenomenon was observed. The uptake was more stimulated by higher H^+ gradient. Initial uptake rate was saturable in the presence of an inward H^+ gradient, with apparent K_m value of 4.2 mM. These findings suggest the involvement of the H^+-coupled carrier-mediated transport in the uptake of enalapril. The uptake was inhibited by ACE inhibitor trandolapril but hardly or only slightly inhibited by aminocephalosporins.
- 公益社団法人日本薬学会の論文
- 1999-07-15
著者
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KITAGAWA Shuji
Niigata College of Pharmacy
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SATO Shinji
Niigata College of Pharmacy
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Kitagawa S
Niigata Univ. Pharmacy And Applied Life Sci. Niigata Jpn
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Kitagawa Shuji
Kobe Pharmaceutical University
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Kitagawa S
Niigata College Of Pharmacy
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Sato S
Ulsi Process Engineering Laboratory Microelectronics Engineering Laboratory Toshiba Corporation
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Sato S
Pharmaceutical Research Laboratories Ajinomoto Co. Inc.
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Takeda Junko
Niigata College Of Pharmacy
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