Inhibitory Effects of Catechol Derivatives on Oxidation of Soybean Phosphatidylcholine Liposomes Induced by Hydrophilic and Hydrophobic Free Radical Initiators

概要

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Effects of pyrocatechol and six of its monosubstituents on oxidation of soybean phosphatidylcholine liposome induced by hydophilic free radical initiator, 2,2'-azobis(2-amidinopropane)dihydrochloride (AAPH), and hydrophobic free radical initiator, 2,2'-azobis(2,4-dimethylvaleronitrile) (AMVN), were determined and relationships with their redox potentials and hydrophobic parameters were studied for their inhibitory effects by regression analysis. Inhibitory potencies of the catechol compounds on hydrophilic AAPH-induced oxidation clearly correlated with their redox potentials, whereas no significant effects of the hydrophobicities of the compounds were found. These results indicated that scavenging activities of these compounds on AAPH-initiated radical chain reactions were controlled by their electron donor activities. Inhibitory potencies of these compounds on hydrophobic AMVN-induced oxidation of liposome, in contrast, were significantly correlated with their hydrophobicity, although regression analysis revealed that their electron donor activities were also important.
公益社団法人日本薬学会の論文
1995-08-15