Inhibitory Effects of Ginsenosides and Their Hydrolyzed Metabolites on Daunorubicin Transport in KB-C2 Cells(Biopharmacy)
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概要
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We studied the effects of ginsenosides and their metabolites on daunorubicin transport in multidrug-resistant P-glycoprotein (P-gp)-overexpressing KB-C2 cells. Ginsenoside Rg1, which is a protopanaxatriol-type ginseng saponin, did not have any effects on the accumulation of P-gp substrate daunorubicin. On the other hand its metabolite M4, which has no sugar moiety, increased the accumulation 3.6-fold at 5 μM. Metabolites of protoanaxadiol-type saponin M1 and M12 also increased accumulation, but the effects were less than that of M4. The findings showed larger effects of metabolites without glucose moieties. Analysis of verapamil-stimulated ATPase activity in membrane vesicles expressing human P-gp suggested that the increased daunorubicin accumulation by M4 was at least partly due to ATPase inhibition of P-gp.
- 公益社団法人日本薬学会の論文
- 2007-10-01
著者
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Kitagawa S
Niigata Univ. Pharmacy And Applied Life Sci. Niigata Jpn
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Kitagawa Shuji
Kobe Pharmaceutical University
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Kitagawa S
Niigata College Of Pharmacy
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NABEKURA Tomohiro
Faculty of Pharmaceutical Sciences Kinki University
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TAKAHASHI Tomoharu
Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences
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TACHIKAWA Eiichi
School of Medicine, Iwate Medical University
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HASEGAWA Hideo
Fermenta Herb Institute Inc.
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Tachikawa Eiichi
School Of Medicine Iwate Medical University
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Nabekura Tomohiro
Faculty Of Pharmaceutical Sciences Niigata University Of Pharmacy And Applied Life Sciences
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Takahashi Tomoharu
Faculty Of Pharmaceutical Sciences Niigata University Of Pharmacy And Applied Life Sciences
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