Enhanced Skin Permeation of Salicylate by Ion-Pair Formation in Non-aqueous Vehicle and Further Enhancement by Ethanol and l-Menthol
スポンサーリンク
概要
- 論文の詳細を見る
Enhancement of skin permeability of salicylate from non-aqueous vehicle by ion-pair formation with either alkylamines or benzylamine as model cationic ions was examined in excised guinea pig dorsal skin. Solubility of salicylate in isopropyl myristate (IPM) was increased by the addition of either alkylamines or benzylamine as counter ions. The increase was more significant in the presence of amines with longer alkyl chains. Flux of salicylate increased in the presence of these amines due to the increase in the solubility. Maximum flux was observed in the presence of n-hexylamine, which induced an 11-fold increase due to 137-fold increase in solubility. Flux and permeability coefficients of salicylate in the presence of n-butylamine, n-hexylamine, iso-octylamine and benzylamine as counter ions in IPM were larger than those of the non-ionic form of salicylic acid. Flux of 3-methylsalicylate (3-CH_3 substituent) and that of 5-hydroxysalicylate (5-OH substituent) were smaller than that of salicylate in the presence of n-hexylamine. After partition to the skin surface, the ion-pair is suggested to dissociate and permeate separately according to the study using lidocaine as the counter ion. Flux of salicylate increased in the presence of benzylamine as the counter ion by the addition of 15% ethanol and 15% ethanol plus 1% l-menthol due to further improvement in the solubility as well as an increase in the permeability coefficient.
- 公益社団法人日本薬学会の論文
- 2006-04-01
著者
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Kamal Mohammad
Faculty Of Pharmaceutical Sciences Niigata University Of Pharmacy And Applied Life Sciences
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Kitagawa S
Niigata Univ. Pharmacy And Applied Life Sci. Niigata Jpn
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Kitagawa Shuji
Kobe Pharmaceutical University
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Kitagawa S
Niigata College Of Pharmacy
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Kitagawa Shuji
Faculty Of Pharmaceutical Sciences Niigata University Of Pharmacy And Applied Life Sciences
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NABEKURA Tomohiro
Faculty of Pharmaceutical Sciences Kinki University
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Iimura Nahoko
Faculty Of Pharmaceutical Sciences Niigata University Of Pharmacy And Applied Life Sciences
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Nabekura Tomohiro
Faculty Of Pharmaceutical Sciences Niigata University Of Pharmacy And Applied Life Sciences
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