Rapid Determination of Total Bromide in Human Serum Using an Energy-Dispersive X-Ray Spectrometer
スポンサーリンク
概要
- 論文の詳細を見る
Since the bromide preparations useful in the treatment of intractable infantile epilepsy show a tendency to accumulate in the body, they may cause chronic toxicosis. To prevent this, determination of the bromide ion concentration in the serum is essential. After establishing a simple and rapid technique using energy-dispersive X-ray spectroscopy for the analysis of the serum total bromide level, we applied this technique in a clinically diagnosed epilepsy patient. The standard curve for total bromide showed linearity (r=0.999) in the range of 10-2000μg/ml, and the lowest detection limit was 5μg/ml. The mean recovery rate of bromide added to reference serum to yield a concentration of 50μg/ml was 93.5% (n=5, coefficient of variation=9.1%). Analysis took only 20min. On analysis of the serum of a 10-year-old girl whose treatment was initiated with orally administered potassium bromide 1.0g/kg, a good correlation was found between the total bromide level obtained with energy-dispersive X-ray spectroscopic analysis and the level of bromide ions determined by ion-exchange HPLC. The determination of serum total bromide by rapid energy-dispersive X-ray spectroscopic analysis is a useful method of monitoring to prevent bromide poisoning.
- 公益社団法人日本薬学会の論文
- 2003-04-01
著者
-
Tanaka Hiroko
Department of Clinical Pharmacology, Niigata University of Pharmacy and Applied Life Sciences
-
Kitagawa Shuji
Faculty Of Pharmaceutical Sciences Niigata University Of Pharmacy And Applied Life Sciences
-
HORI Yasushi
Department of Analytical Chemistry, Faculty of Pharmaceutical Sciences, Niigata University of Pharma
-
FUJISAWA Manami
Department of Analytical Chemistry, Faculty of Pharmaceutical Sciences, Niigata University of Pharma
-
YOSHIKAWA HIDETO
Department of Neurology, Miyagi Children's Hospital
-
NAKAJIMA Mariko
Department of Biopharmacy, University of Shizuoka School of Pharmaceutical Sciences
-
Yoshikawa Hideto
Department Of Neurology Miyagi Children's Hospital
-
Hori Yasushi
Department Of Analytical Chemistry Faculty Of Pharmaceutical Sciences Niigata University Of Pharmacy
-
Hori Y
Niigata Univ. Pharmacy And Applied Life Sci. Niigata Jpn
-
Yoshikawa H
Department Of Pediatrics Niigata City General Hospital
-
Kasamaki M
Dep. Of Hospital Pharmacy Niigata City General Hospital
-
KASAMAKI Masatoshi
Department of Hospital Pharmacy, Niigata City General Hospital
-
Fujisawa Manami
Department Of Analytical Chemistry Faculty Of Pharmaceutical Sciences Niigata University Of Pharmacy
-
Fujisawa Manami
Department Of Hospital Pharmacy Niigata City General Hospital
-
Tanaka Hiroko
Department Of Clinical Pharmacology Niigata University Of Pharmacy And Applied Life Sciences
-
Nakajima Mariko
Department Of Hospital Pharmacy Niigata City General Hospital
-
Nakajima Mariko
Department Of Biopharmacy University Of Shizuoka School Of Pharmaceutical Sciences
-
Tanaka Hiroko
Department Of Hospital Pharmacy Niigata City General Hospital : Faculty Of Pharmaceutical Sciences N
-
Tanaka Hiroko
Department Of Chemistry Graduate School Of Science The University Of Tokyo
関連論文
- PE-353 Comparative Effects of Torasemide and Furosemide in Rats with Chronic Heart Hailure after Autoimmune Myocarditis(PE059,Heart Failure (Treatment) 2 (M),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- Benign Pleomorphic Adenoma with Extensive Cystic Degeneration : Unusual MR Findings in Two Cases
- Brown Tumor of the Sphenoid Sinus in a Patient with Secondary Hyperparathyroidism : CT and MR Imaging Findings
- CT and MR Findings of Basal Cell Adenoma of the Parotid Gland
- Rapid Analysis of 4-O-Methylpyridoxine in the Serum of Patients with Ginkgo Biloba Seed Poisoning by Ion-Pair High-Performance Liquid Chromatography (Analytical Biochemistry)
- Effect of Dietary Phosphate on Na^+-Dependent Phosphate Cotransporters Function and Expression in the Rat Kidney
- Neonatal-Onset Brainstem Reticular Reflex Myoclonus Following a Prenatal Brain Insult : Generalized Myoclonic Jerk and a Brainstem Lesion
- Assessment of Mucosal Immune Response in Genitourinary Tract Using Urine
- Usefulness of MR Imaging in Assessment of Tumor Extent of Aggressive Fibromatosis
- In Vivo Measurement of 1, 4-Dihydropyridine Receptors in Mesenteric Arteries of Spontaneously Hypertensive Rats and Effect of Nifedipine and Cilnidipine
- Malignant mucosal melanoma of the eustachian tube
- Hypouricemia in severely disabled children II : influence of elemental enteral nutrition on the serum uric acid levels
- Acute respiratory distress syndrome in children with severe motor and intellectual disabilities
- Tubulo-interstitial nephritis caused by sodium valproate
- Haloperidol-induced rhabdomyolysis without neuroleptic malignant syndrome in a handicapped child
- Midazolam as a first-line agent for status epilepticus in children
- Japanese siblings with congenital chloride diarrhea
- Extremely Acute Phenytoin-Induced Peripheral Neuropathy
- OE-322 Comparative Effects of V2 Receptor Antagonist Tolvaptan and the Loop Diuretic Furosemide in Rats with Heart Failure after Autoimmune Myocarditis(OE55,Heart Failure (Treatment) 2 (M),Oral Presentation (English),The 73rd Annual Scientific Meeting of
- Lewis Acid-Promoted Disproportionation Reaction of Aromatic Vinyl Ethers and Acetals and Its Application to the Synthesis of Paracotoin
- Studies on Augmenting the Growth-inhibition Activity of α,β-Unsaturated Aldehydes and Ketones against Rhodotorula gracilis(Organic Chemistry)
- Synthesis of Aliphatic Dienedials, ω-Hydroxydienals, ω-Hydroxy-2-alkenals, Vinylketones, an Enon-enal and Aliphatic Dienediones(Organic Chemistry)
- Hypoparathyroidism and facial dysmorphism as main symptoms of 22q.11 deletion syndrome
- Rapid Analysis Method for Paraquat and Diquat in the Serum Using Ion-Pair High-Performance Liquid Chromatography(Analytical Biochemistry)
- Hypouricemia in severely disabled children : influence of valproic acid and bed-ridden state
- Method for Screening and Quantitative Determination of Serum Levels of Salicylic Acid, Acetaminophen, Theophylline, Phenobarbital, Bromvalerylurea, Pentobarbital, and Amobarbital Using Liquid Chromatography/Electrospray Mass Spectrometry(Analytical Bioche
- Toxicokinetics of DL-Glufosinate Enantiomer in Human BASTAR Poisoning
- Rapid Determination of Total Bromide in Human Serum Using an Energy-Dispersive X-Ray Spectrometer
- Acquired aphasia in acute disseminated encephalomyelitis
- Enhanced Skin Permeation of Salicylate by Ion-Pair Formation in Non-aqueous Vehicle and Further Enhancement by Ethanol and l-Menthol
- Permeability of Ionized Salicylate Derivatives through Guinea Pig Dorsal Skin
- Enhanced Delivery of Retinoic Acid to Skin by Cationic Liposomes
- Nonuniform Spin Triplet Superconductivity due to Antisymmetric Spin-Orbit-Coupling in Noncentrosymmetric Superconductor CePt_3Si(Condensed matter: electronic structure and electrical, magnetic, and optical properties)
- Cationic Vesicles Consisting of 1, 2-Dioleoyl-3-Trimethylammonium Propane (DOTAP) and Phosphatidylcholines and Their Interaction with Erythrocyte Membrane
- Modification of Mutagenic Activities of Pro-Mutagens by Glyco-Ursodeoxycholic Acid in the Ames Assay
- Hemiballismus associated with Influenza A infection
- Remarkable improvement of severe diffuse axonal injury without L-dopa treatment
- Carbamazepine-induced abnormal pitch perception
- Comparison of Anion Transport Inhibition by Benzensulfonic Acid Derivatives in Rat and Bovine Erythrocyte Membranes
- Schinzel-Giedion syndrome : A further cause of early myoclonic encephalopathy and vacuolating myelinopathy
- Asymmetric Diels-Alder reactions of an acrylic acid derivative using a chiral titanium catalyst.
- International Health and Medical Cooperation by Japanese Nurses. Analysis on Nurses Dispatched for Overseas Activities by the Japanese Government in the Past 30 Years.:ANALYSIS ON NURSES DISPATCHED FOR OVERSEAS ACTIVITIES BY THE JAPANESE GOVERNMENT IN THE
- The theory of the reverse diffusion of ions in mixed electrolyte solutions and experimental results on the HCl-CaCl2-H2O ternary system.