Comparison of Anion Transport Inhibition by Benzensulfonic Acid Derivatives in Rat and Bovine Erythrocyte Membranes

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概要

• 論文の詳細を見る

• Transport system of rat and bovine erythrocyte membranes was studied comparatively by the observation of the inhibitory effects of benzenesulfonic acid derivatives on the transport of oxalate through both membranes. Although the permeability of rat erythrocyte membrane was larger than that of bovine erythrocyte membrane, the inhibitory effects of benzenesulfonic acid derivatives in both membranes resembled with each other. It was shown that the electronic property has a significant effect, but the hydrophobic property has less effect : the inhibitory effects are mainly dependent on the electron acceptor capacities. The position of the substituents was also revealed to be important for the inhibition. Moreover, in rat erythrocy te membrane, the order of the inhibitory effects of benzenesulfonic acid derivatives is almost completely reverse to that of transport rates. This strongly clarifies that the transport is regulated by the binding capacities of anions to the transport site.<BR>In this study the usefulness of ammonium salt lysis method to measure the inhibitory effects was also revealed.

• 日本膜学会の論文

著者

• Kitagawa Shuji

  Faculty Of Pharmaceutical Sciences Niigata University Of Pharmacy And Applied Life Sciences

• Toyota Masahito

  Faculty of Pharmaceutical Sciences, University of Tokushima

• Kametani Fujio

  Faculty of Pharmaceutical Sciences, University of Tokushima

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