RESPONSE DIFFERENCES AMONG MOUSE STRAINS IN DNA DAMAGE AND SKIN CARCINOGENICITY OF 7,12-DIMETHYLBENZ[a]ANTHRACENE ARE DUE TO INDUCIBLE ARYL HYDROCARBON HYDROXYLASE ACTIVITY
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概要
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Strain differences of mice in the induction of DNA damage in peripheral blood cells and skin tumors were investigated using 7,12-dimethylbenz[a]anthracene (DMBA). DMBA-induced DNA damage and skin tumorigenesis were evaluated using the single cell gel electrophoresis (SCGE) assay and 2-stage carcinogenicity study, respectively. DNA damaged cells were markedly increased in the aryl hydrocarbon hydroxylase (AHH)-inducible mice, BALB/c and C57BL/6,as compared with the AHH-noninducible mice, DBA/2,in the SCGE assay. The AHH-inducible mice were more sensitive to DMBA than the AHH-noninducible mice in the 2-stage carcinogenicity study. These results strongly suggest that the genetic capacity to metabolize PAH is associated with the mutagenecity and carcinogenecity of DMBA.
- 公益社団法人日本薬学会の論文
- 1998-01-15
著者
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佐藤 真治
新潟薬科大学 薬理
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Tomita I
Shizuoka Sangyo Univ. Shizuoka Jpn
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Tomita Isao
University Of Shizuoka School Of Pharmaceutical Sciences
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Tomita Isao
University Of Shizuoka
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SATO Sei-ichi
Toxicology Research Laboratories
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佐藤 眞治
Pharmaceutical Research Laboratories Ajinomoto Co. Inc.
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Sato Shinji
Department Of Pharmaceutics Niigata College Of Pharmacy
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