CHANGES IN TISSUE CONTENTS OF ZINC, COPPER AND IRON IN RATS AND BEAGLE DOGS TREATED WITH POLAPREZINC
スポンサーリンク
概要
- 論文の詳細を見る
Zinc, copper and iron levels of tissues in rats or beagle dogs were measured after a 13- or 52-week toxicity study of polaprezinc, which contains a zinc element; The zinc content in almost all rat tissues remarkably increased with a conspicuous decrease of copper and various changes of iron at doses of 600 mg/kg/day or more. Zinc and copper levels increased and decreased respectively, at 300 mg/kg/day. At a dose of 150 mg/kg/day, there was a slight increase of zinc in some tissues at 52-weeks, but no copper decrease. The results obtained from beagle dogs differed somewhat from that in rats. Dogs treated with polaprezind at 50 mg/kg/day or more accumulated zinc in some tissues. A copper decrement was seen only in the liver and heart from the group given 300 mg/kg/day, whereas copper levels in the kidney of all treated groups were higher than that in the controls suggesting that canine polaprezinc toxicity is due to direct zinc toxic effects.
- 日本トキシコロジー学会の論文
- 1996-08-25
著者
-
柴田 清孝
岩手大 工
-
Takei Mineo
Central Research Laboratories, Zeria Pharmaceutical Co., Ltd.
-
Takei M
Central Research Laboratories Zeria Pharmaceutical Co. Ltd.
-
Takei Mineo
Central Research Laboratories Zeria Pharmaceutical Co. Ltd.
-
Takei Mineo
Pharmacological Reserch Department Central Research Laboratories Zeria Pharmaceutical Co. Ltd.
-
Yamaguchi Itaru
キリンビール
-
YAMAGUCHI Itaru
Toxicological Research Department, Central Research Laboratories, Zeria Pharmaceutical Co., Ltd.
-
SHIBATA Keizo
Toxicological Research Department, Central Research Laboratories, Zeria Pharmaceutical Co., Ltd.
-
MATSUDA Kazuo
Toxicological Research Department, Central Research Laboratories, Zeria Pharmaceutical Co., Ltd.
-
Yamaguchi Itaru
Toxicological Research Department Central Research Laboratories Zeria Pharmaceutical Co. Ltd.
-
Shibata Kenji
Department Of Toxicology And Safety Assessment Kawanishi Pharma Research Institute Nippon Boehringer
-
Matsuda Katsuichi
Toxicological Research Department Central Research Laboratories Zeria Pharmaceutical Co. Ltd.
-
Shibata K
Meteorological Research Institute
-
SHIBATA Kaoru
Institute for Materials Research, Tohoku University
関連論文
- KEY PARAMETERS OF SPERM MOTION IN RELATION TO MALE FERTILITY IN RATS GIVEN α-CHLOROHYDRIN OR NITROBENZENE
- Pharmacological Evaluation of Analgesic Effects of the Cholecystokinin2 Receptor Antagonist Z-360 in Mouse Models of Formalin- and Cancer-Induced Pain
- High Resolution Neutron Spectrometer LAM-80ET and Rotational Tunnelling in 4-Methypyridine N-Oxide
- 1a-A-3 NaBr:S^におけるthermoluminescence過程
- Revised Results for the Band Properties of Black Phosphorus
- 黒リンの電子構造と圧力下での構造特性
- The Energy Band Structure of Black Phosphorus and Angle-Resolved Ultraviolet Photoelectron Spectra
- Z-100, an Immunomodulatory Arabinomannan Extracted from Mycobacterium tuberculosis Strain Aoyama B, Augments Anti-tumor Activities of X-Ray Irradiation against B16 Melanoma in Association with the Improvement of Type 1T Cell Responses(Miscellaneous)
- Antimetastatic Effect of an Immunomodulatory Arabinomannan Extracted from Mycobacterium tuberculosis Strain Aoyama B, Z-100, through the Production of Interleukin-12(Miscellaneous)
- Z-360, a Novel Cholecystokinin-2/Gastrin Receptor Antagonist, Inhibits Gemcitabine-Induced Expression of the Vascular Endothelial Growth Factor Gene in Human Pancreatic Cancer Cells
- Isothermal Evolution of Long Range Order in Bulk Metallic Glass Ni_Pt_P_ near Glass Transition : In-Situ SANS Measurement
- CHANGES IN TISSUE CONTENTS OF ZINC, COPPER AND IRON IN RATS AND BEAGLE DOGS TREATED WITH POLAPREZINC
- 101 CHANGES IN CONTENTS OF ZINC, COPPER AND IRON IN ANIMAL TISSUES AFTER REPEATED ORAL ADMINISTRATION OF Z-103
- Hormonal Effects of Z-350, Possessing Steroid 5α-Reductase Inhibitory and α_1-Adrenoceptor Antagonistic Actions, in the Rat
- Z-335,a Thromboxane A_2 Receptor Antagonist, Suppresses the Progression of Arachidonic Acid-Induced Hind Limb Gangrene in Rats
- Arachidonic Acid-Induced Hind Limb gangrene : A New Experimental Rat Model of Paripheral Vascular Disease
- Apparent stratospheric ozone loss rate over Eureka in 1994/95, 1995/96, and 1996/97 inferred from ECC ozonesonde observations
- Stratospheric Ozone Loss over Eureka in 1999/2000 Observed with ECC Ozonesondes
- Photoconductive Decay Measurements on Semiconducting Black Phosphorus Crystals
- Photoconduction of Black Phosphorus in the Infrared Region
- Ion Dynamics of Glass-Forming Nitrate Melts
- Quasielastic and Inelastic Neutron Scatterings of Liquid Tellurium
- Dynamics of Polyethylene Studied by High Resolution Neutron Spectrometer LAM-80ET
- Quasielastic Neutron Scattering from Amorphous Polymers above Glass Transition Temperature
- Two-Dimensional Anderson Localization in Black Phosphorus Crystals Prepaerd by Bismuth-Flux Method
- EVALUATION OF THE INDUCTION OF HEPATIC DRUG-METABOLIZING ENZYMES IN THE RAT AND MOUSE TREATED WITH TEMAZEPAM USING TRIMETHADIONE AS THE INDICATOR
- Thermoluminescence and Optical Absorption of NaBr:S^ Crystals
- Optical Properties of Black Phosphorus and Its Application to the Infrared Detector (SOLID STATE DEVICES AND MATERIALS 1)
- Generalized Equivalence Principle in Extended New General Relativity
- 315 SUBACUTE EFFECTS OF GUM ARABIC IN THE RAT
- Histopathological, Immunohistochemical and Ultrastructural Studies of a Renal Mesenchymal Tumor in a Young Beagle dog
- Low-Energy Excitation in β-Cu_2Se
- Ion Dynamics of Glass-Forming Nitrate Melts
- Spontaneous Adenosquamous Carcinoma with Rapid Growth and EMT-like Changes in the Mammary Gland of a Young Adult Female BALB/c Mouse
- Spontaneous Malignant T Cell Lymphoma in a Young Male Common Marmoset (Callithrix jacchus)