ANTITUMOR EFFECT OF POLYSACCHARIDE GRIFOLAN NMF-5N ON SYNGENEIC TUMOR IN MICE

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概要

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• Antitumor activity of grifolan NMF-5N, a β-1,3-glucan obtained from mycelia of Grifola frondosa, was examined. Grifolan NMF-5N showed antitumor activities in allogeneic and syngeneic murine tumor systems. In the allogeneic tumor system, a potent antitumor activity over 95% was observed against the solid form of sarcoma 180 when grifolan NMF-5N was injected intraperitoneally (i.p.) at 25-200 μg/mouse daily for 10 successive days. In the syngeneic tumor systems, significant antitumor activities were observed against Meth A fibrosarcoma and MM 46 carcinoma by injection at 100 μg/mouse daily for 5 successive days, especially i.p. injection at day 7-11,when the tumor cells were inoculated subcutaneously (s.c.) on day 0. Moreover, when grifolan NMF-5N was injected i.p. every other week, significant antitumor activity was also observed. In addition, a single treatment with grifolan NMF-5N at 500 μg/mouse showed antitumor activities. Grifolan NMF-5N exhibited antitumor activities against these two syngeneic tumors by intraveneous (i.v.) injection. However, a marked inhibitory activity was observed by intratumorous (i.t.) injection against Meth A fibrosarcoma but not against MM46 carcinoma. These results suggest that antitumor activities of grifolan NMF-5N in murine syngeneic tumor systems depend on not only dosage but also injection routes and timing.

• 社団法人日本薬学会の論文

著者

• OHNO NAOHITO

  Tokyo College of Pharmacy

• Ohno Naohito

  Lab. For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo Univ. Of Pharmacy And Lif

• YADOMAE Toshiro

  Tokyo University of Pharmacy and Life Science, School of Pharmacy

• Suzuki Y

  Meijo Univ. Nagoya Jpn

• SUZUKI IWAO

  Tokyo College of Pharmacy

• OIKAWA Shozo

  Tokyo College of Pharmacy

• Ohno Naohito

  Laboratory For Immunopharmacology Of Microbial Products Tokyo University Of Pharmacy And Life Scienc

• TAKEYAMA Takahiro

  Tokyo College of Pharmacy

• SATO Kichiro

  Tokyo College of Pharmacy

• SUZUKI YOSHIYUKI

  Tokyo College of Pharmacy

• Suzuki Y

  Faculty Of Pharmacy Meijo University

• Oikawa S

  Nippon Beet Sugar Mfg. Co. Ltd. Tokyo Jpn

• Sato K

  Toyama Medical And Pharmaceutical Univ. Toyama Jpn

• Suzuki Iwao

  Faculty Of Pharmaceutical Sciences Tohoku University

• Yadomae T

  Laboratory For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm

• Yadomae Toshiro

  Tokyo College Of Pharmacy

• Takeyama Takahiro

  Tokyo College Of Pharmacy:nippon Beet Sugar Mfg. Co. Ltd.

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