Synergistic Action of β-Glucan and Platelets on Interleukin-8 Production by Human Peripheral Blood Leukocytes
スポンサーリンク
概要
- 論文の詳細を見る
The effects of human platelets on interleukin(IL)-8 production from human peripheral blood mononuclear cells(PBMCs)and polymorphonuclear leukocytes(PMNs)stimulated with the fungal(1→3)-β-D-glucan schizophyllan(SPG)were examined using ELISA. PBMCs/PMNs in the presence of platelets and SPG enhanced IL-8 production in comparison with those in the presence of either platelets or SPG. IL-8 production was dependent on the concentration of platelets and incubation time, and the activity reached the maximal level at 18 h of incubation. These activities were also observed with the addition of platelets prestimulated with SPG to PBMCs. Addition of SPG directly enhanced expression of P-selectin on platelet membrane surfaces. These results suggest that platelets play a key role in the cytokine production of leukocytes induced by fungal(1→3)-β-D-glucans and might be mediated, at least in part, by P-selectin.
- 社団法人日本薬学会の論文
- 2002-01-01
著者
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OHNO Naohito
Laboratory far Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pha
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Ohno Naohito
東京薬科大学 免疫学
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Ohno Naohito
東京薬科大学 薬 微生物
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Ohno Naohito
Lab. For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo Univ. Of Pharmacy And Lif
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Ohno N
Laboratory For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm
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Adachi Yoshiyuki
東京薬科大学 免疫学
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Adachi Y
Tokyo Univ. Pharmacy And Life Sci. Tokyo Jpn
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Adachi Yoshiyuki
Laboratory Far Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm
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YADOMAE Toshiro
Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pha
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TSUZUKI Aiko
Laboratory of Immunophamacology of Microbial Products, School of Pharmacy, Tokyo University of Pharm
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SUZUKI Tatsuya
Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pha
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OHSHIMA Yukio
Laboratory of Microbiology, Hatano Research Institute, Food and Drug Safety Center
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Adachi Yoshiyuki
Laboratory For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm
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Ohno Naohito
Laboratory Of Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharma
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Ohno Naohito
Laboratory For Immunopharmacology Of Microbial Products Tokyo University Of Pharmacy And Life Scienc
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Suzuki T
Josai Univ. Saitama Jpn
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Tsuzuki Aiko
Laboratory For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm
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Ohshima Yukio
Laboratory Of Microbiology Hatano Research Institute Food And Drug Safety Center
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Yadomae T
Laboratory For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm
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Ohno Naohito
Laboratory For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm
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Suzuki Tatsuya
Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Science:Laboratory of Microbiology, Hatano Research Institute, Food and Drug Safety Center
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