Expression of Interleukin 1 Family mRNAs by a Highly Branched (1→3)-β-D-Glucan, OL-2
スポンサーリンク
概要
- 論文の詳細を見る
OL-2,a highly branched (1→3)-β-D-glucan, is an antitumor glucan showing strong hematopoietic activity with weaker adjuvant activity than schizophyllan (SPG), also an antitumor glucan and one which is clinically used. This paper deals with the gene expression of the interleukin 1 (IL-1) family in mice by OL-2 and SPG in order to characterize the immunopharmacological activity. Gene expression was examined by reverse transcriptase-polymerase chain reaction method. Intraperitoneal administration of OL-2 (250 μg/mouse) expressed all three genes of IL-1α, β, and IL-1 receptor antagonist (IL-1ra) in the peritoneal exudate cells, while SPG induced a strength of IL-1α mRNA comparable to that by OL-2 but a weaker level of IL-1β mRNA. SPG did not induce IL-1ra. Similar patterns were seen in spleen and liver by OL-2 or SPG administration. These findings suggest that the immunopharmacological characteristics of (1→3)-β-D-glucan are regulated under the gene expression of the IL-1 family.
- 社団法人日本薬学会の論文
- 1993-10-15
著者
-
大野 尚仁
東京薬科大学薬学部免疫学教室
-
大野 尚仁
Laboratory of Immunopharmacology of Microbial Products, Tokyo University of Pharmacy and Life Scienc
-
安達 禎之
Laboratory of Immunopharmacology of Microbial Products, Tokyo University of Pharmacy and Life Scienc
-
宿前 利郎
Laboratory of Immunopharmacology of Microbial Products, Tokyo University of Pharmacy and Life Scienc
-
宿前 利郎
東京薬科大学 薬 免疫
-
宿前 利郎
東京薬科大学
-
根本 二郎
Laboratory of Immunopharmacology of Microbial Products, Tokyo College of Pharmacy
-
斎藤 和夫
The Tokyo Metropolitan Research Laboratory of Public Health
-
安達 禎之
東京薬科大学免疫学
-
大野 尚仁
東京薬科大学免疫学
-
大野 尚仁
帝京大学 医学部微生物学講座
-
根本 二郎
Laboratory Of Immunopharmacology Of Microbial Products Tokyo College Of Pharmacy
-
安達 禎之
Laboratory Of Immunopharmacology Of Microbial Products Tokyo College Of Pharmacy
-
Ohno N
Lab. Immunopharmacolgy Of Microbial Products Tokyo University Of Pharmacy And Life Science School Of
-
Adachi Yoshiyuki
Laboratory For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm
関連論文
- 薬学部新入学生の早期体験実習におけるKJ法を用いたスモールグループディスカッションの有用性
- CAWS血管炎惹起の分子メカニズム
- Inactivation of (1→3)-β-D-Glucan in Mice
- Modulation of the Antitumor Effect and Tissue Distribution of Highly Branched (1→3)-β-D-Glucan, SSG, by Carrageenan
- Relationship between the Tissue Distribution and Antitumor Activity of Highly Branched (1→3)-β-D-Glucan, SSG
- Structure-Activity Relationship of (1→3)-β-D-Glucans in the Induction of Cytokine Production from Macrophages, in Vitro
- Comparison of the Immunopharmacological Activities of Triple and Single-Helical Schizophyllan in Mice
- D-11 漢方薬熱水抽出過程での成分間相互作用への遊離アミノ酸ならびに単糖の関与
- Resistance of Highly Branched (1→3)-β-D-Glucans to Formolysis
- Structural Analysis of Alkaline-Soluble Polysaccharide, P-1,from the Kernels of Prunus mume SIEB. et ZUCC.
- Comparison of the Blood Clearance of Triple- and Single-Helical Schizophyllan in Mice
- Enhancement of LPS Triggered TNF-α (Tumor Necrosis Factor-α) Production by (1→3)-β-D-Glucans in Mice
- Enhancement of Cytokine Production by Macrophages Stimulated with (1→3)-β-D-Glucan, Grifolan (GRN), Isolated from Grifola frondosa
- Preparation and Antigen Specificity of an Anti-(1→3)-β-D-glucan Antibody
- Analysis of Cytokine mRNAs Induced by the Administration of a Highly Branched (1→3)-β-D-Glucan, OL-2
- Changes in Immune Mediators in Mouse Lung Produced by Administration of Soluble (1→3)-β-D-Glucan
- Biological Activity and Structural Characterization of Alkaline-Soluble Polysaccharides from the Kernels of Prunus mume SIEB. et ZACC.
- Expression of Interleukin 1 Family mRNAs by a Highly Branched (1→3)-β-D-Glucan, OL-2
- Application of Limulus Test (G Pathway) for the Detection of Different Conformers of (1→3)-β-D-Glucans
- Inhibitory Effect of β-Glucans on Zymosan-Mediated Hydrogen Peroxide Production by Murine Peritoneal Macrophages in Vitro
- Immunopharmacological Characterization of a Highly Branched Fungal (1→3)-β-D-Glucan, OL-2,Isolated from Omphalia lapidescens
- Binding of Lysozyme to Synthetic Monosaccharide Lipid A Analogue, GLA60
- SY1-4 免疫疾患に関わる真菌多糖と自然免疫受容体(真菌と免疫・アレルギー,シンポジウム1,医真菌学のコペルニクス的転回を目指して)
- P-071 シクロフォスファミド投与白血球減少症モデルマウスにおけるCandida由来PAMPsへの応答性の検討(免疫・アレルギー,ポスター討論,一般演題,医真菌学のコペルニクス的転回を目指して)
- P-072 真菌症患者血清における抗β-グルカン抗体のβ1,3/β1,6構造に対する反応性の比較(免疫・アレルギー,ポスター討論,一般演題,医真菌学のコペルニクス的転回を目指して)
- Characterization of Mitogenic Substances in the Hot Water Extracts of Bupleuri Radix
- 血管炎発症に関わる活性化好中球MPO分子の蛍光ナノ粒子による検出
- 01P2-006 DBA/2系マウスに惹起されるCAWS血管炎の心機能異常を伴う致死的病態モデルとしての有用性に関する検討(薬物療法(基礎と臨床),医療薬学の扉は開かれた)
- 免疫異常による腎臓血管傷害のイメージング
- Monoclonal Antibody to Proteoglycan Derived from Grifola frondosa (Maitake)
- P-153 ヒト抗β-グルカン抗体価の検討(6.服薬指導(入院・外来)2,医療薬学の未来へ翔(はばた)く-薬剤師の薬剤業務・教育・研究への能動的関わり-)
- 真菌細胞壁の構造と機能--受容体との関連も含めて (特集 糖尿病と真菌症--臨床免疫と分子生物学的アプローチ) -- (真菌に関する基礎的事項)
- ベアード・パーカー寒天培地とウサギ血しょうフィブリノーゲン寒天培地のJIS化について
- CAWSによって惹起される致死的血管炎モデル--CAWS惹起冠状動脈炎 (第1土曜特集 血管炎の基礎と臨床) -- (基礎)
- Serum Components Induce β-D-Glucan-Inhibitable Uptake of Zymosan Particles by Murine Peritoneal Macrophages
- Heat Induced Conformational Changes Generate Mitogenicity to Splenocytes by Sclerogen from Sclerotinia sclerotiorum IFO 9395
- Physicochemical Characteristics and Antitumor Activities of a Highly Branched Fungal (1→3)-β-D-Glucan, OL-2,Isolated from Omphalia lapidescens
- Intravenously Administered (1→3)-β-D-Glucan, SSG, Obtained from Sclerotinia sclerotiorum IFO 9395 Augments Murine Peritoneal Macrophage Functions in Vivo
- Solubilization of Limulus Test Reactive Material(s) from Candida Cells by Murine Phagocytes
- Activation of Complement and Limulus Coagulation Systems by an Alkali-Soluble Glucan Isolated from Omphalia lapidescens and Its Less-Branched Derivatives. (Studies on Fungal Polysaccharide. XXXIX)
- Structure and Antitumor Activity of the Less-Branched Derivatives of an Alkali-Soluble Glucan Isolated from Omphalia lapidescens. (Studies on Fungal Polysaccharide. XXXVIII)
- Inhibition of Expeirmental Pulmonary Metastasis of Lewis Lung Carcinoma by Orally Administered β-Glucan in Mice
- Isolation of Mitogenic Substance from Sclerotia of Sclerotinia sclerotiorum IFO 9395 Extracted with Phosphate Buffer
- 薬学生のための免疫の本
- Effect of Intraperitoneally Administered β-1,3-Glucan, SSG, Obtained from Sclerotinia sclerotiorum IFO 9395 on the Functions of Murine Alveolar Macrophages
- Preparation and Antitumor Activity of Hydroxyethylated Derivatives of 6-Branched (1→3)-β-D-Glucan, SSG, Obtained from the Culture Filtrate of Sclerotinia sclerotiorum IFO 9395
- Heat Induced Generation of the Mitogenic Substance(s) Responding to Murine Splenocytes Obtained from Sclerotia of Sclerotinia sclerotiorum IFO 9395
- Macrophage Activation in Vitro by Chemically Cross-Linked (1→3)-β-D-Glucans
- Change of Biological Activities of (1→3)-β-D-Glucan from Grifola frondosa upon Molecular Weight Reduction by Heat Treatment
- Separation of the Hot Water Extracts of Sclerotia of Sclerotinia sclerotiorum IFO 9395 into Mitogenic and Antitumor-Active Subfractions
- Physicochemical Properties and Antitumor Activities of Chemically Modified Derivatives of Antitumor Glucan "Grifolan LE" from Grifola frondosa
- Antitumor and Immunomodulating Activities of a β-Glucan Obtained from Liquid-Cultured Grifola frondosa
- Rapid Measurement of Phagocytosis by Macrophages
- Dissociation of a Glucan Fraction (CO-1) from Protein-Bound Polysaccharide of Cordyceps ophioglossoides and Analysis of Its Antitumor Effect
- Conformation of Grifolan in the Fruit Body of Grifola frondosa Assessed by Carbon-13 Cross Polarization-Magic Angle Spinning Nuclear Magnetic Resonance Spectroscopy(Biological)
- Effect of Grifolan on the Ascites Form of Sarcoma 180(Biological)
- Conformational Changes of the Two Different Conformers of Grifolan in Sodium Hydroxide, Urea or Dimethylsulfoxide Solution(Biological)
- Effect of Activation or Blockade of the Phagocytic System on the Antitumor Activity of Grifolan
- Fractionation of Acidic Antitumor β-Glucan of Grifola frondosa by Anion-Exchange Chromatography Using Urea Solutions of Low and High Ionic Strengths
- Two Different Conformations of Antitumor Glucans Obtained form Grifola frondosa
- Effect of Glucans on the Antitumor Activity of Grifolan
- Characterization of the Antitumor Clucan Obtained from Liquid-Cultured Grifola frondosa
- Structure-Function Relationship of Antitumor β-1,3-Glucan Obtained from Matted Mycelium of Cultured Grifola frondosa
- Purification and Structural Characterization of an Antitumor β-1,3-Glucan Isolated from Hot Water Extract of the Fruit Body of Cultured Grifola frondosa
- Structural Characterization and Antitumor Activity of the Extracts from Matted Mycelium of Cultured Grifola frondosa
- CAWS血管炎への Bruton's tyrosine kinase の関与に関する検討
- 肺胞マクロファージの真菌細胞壁成分によるNF-κB活性化ならびにサイトカイン発現誘導の検討
- ヒト抗β-グルカン抗体のクラス別力価と反応性
- 遺伝的素因の異なるマウスを用いたCAWS血管炎の検討
- 肺胞マクロファージの真菌細胞壁成分によるNF-κB活性化ならびにサイトカイン発現誘導の検討
- 真菌細胞壁多糖に対するマクロファージの応答性
- 真菌多糖の免疫系による認識とその活性化作用
- 可溶化βグルカンの経気道曝露による気道炎症
- 可溶化βグルカンの経気道曝露による気道炎症
- 10 可溶化βグルカンの経気道曝露による気道炎症 : 第2報
- β-グルカンの構造と免疫賦活機構の解析 (特集 β-グルカンの機能性研究最新情報)
- Candida albicans培養液中の可溶性多糖画分(CAWS)によってDBA/2系マウスに惹起される血管炎の病理組織学的検討と致死毒性の解析
- P-434 血管病変解析と治療薬創生のためのCAWS誘発血管炎の応用(1.薬物療法(基礎と臨床)5,医療薬学の未来へ翔(はばた)く-薬剤師の薬剤業務・教育・研究への能動的関わり-)
- マウス脾細胞におけるbeta-glucan応答性遺伝子の網羅的解析
- 真菌β-1,3-グルカンの構造と生物活性
- 可溶化βグルカンの経気道暴露によるサイトカイン発現と気道炎症
- Structural Analysis of Glucan by Identification of Methylated Sugars by Proton Magnetic Resonance Spectra
- βグルカンの生体防御系修飾作用
- 「薬学会論文誌をより良くするために」のパネルを読んで
- 肺炎球菌細胞壁中に存在する, リゾチーム消化抵抗性因子
- 血管炎を誘導する真菌糖蛋白質の免疫活性化 (血管炎研究がめざすあらたな展開) -- (血管炎発症機構の解析研究)
- マウス脾細胞における beta-glucan 応答性遺伝子の網羅的解析
- P-063 無脊椎動物β-グルカン認識タンパク質の結合活性におけるグルカン構造特異性の解析(一般演題(ポスター発表),基礎から臨床へ、臨床から基礎への提案)
- P-068(O2-2-5) 補体C5欠損マウスを用いたCAWS血管炎の検討(カンジダの基礎と臨床(2),一般演題(ポスター発表),基礎から臨床へ、臨床から基礎への提案)
- P-058(O2-1-3) ヒト白血球におけるβ-グルカン応答性因子の検討(カンジダの基礎と臨床(1),一般演題(ポスター発表),基礎から臨床へ、臨床から基礎への提案)
- P-056(O2-1-1) Candida albicans可溶性多糖画分CAWS投与マウス肝臓における遺伝子発現の網羅的解析(カンジダの基礎と臨床(1),一般演題(ポスター発表),基礎から臨床へ、臨床から基礎への提案)
- S4-1 真菌感染防御における好中球由来の活性酸素の役割(真菌と感染防御,基礎・臨床シンポジウム4,基礎から臨床へ、臨床から基礎への提案)
- アレルギー・炎症に関わる真菌多糖と自然免疫受容体 (特集 真菌とアレルギー・炎症)
- P-099 病原性真菌Candida albicans由来多糖CAWSの静脈内投与により惹起される血管炎の解析(一般演題(ポスター発表),生態と進化から考える医真菌学)
- P-098 CAWS血管炎のA/Jマウスを用いた解析(一般演題(ポスター発表),生態と進化から考える医真菌学)
- P-097 自然免疫系βグルカン結合タンパクのグルカン構造特異性(一般演題(ポスター発表),生態と進化から考える医真菌学)
- P-088(SS6-4) カンジダマンナンによる血管炎モデルにおける構造要求性について(一般演題(ポスター発表),生態と進化から考える医真菌学)
- P-087 カンジタ感染患者における抗β-グルカン抗体価のアイソタイプ別の検討(一般演題(ポスター発表),生態と進化から考える医真菌学)
- P-085 Candida albicans由来のβ-glucan 画分によるヒト好中球のERKおよびp38 MAPK燐酸化への影響(一般演題(ポスター発表),生態と進化から考える医真菌学)
- 好中球機能異常による感染防御能の低下と炎症の誘発